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A5CD00 (SYR_ORITB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:OTBS_0571
OrganismOrientia tsutsugamushi (strain Boryong) (Rickettsia tsutsugamushi) [Complete proteome] [HAMAP]
Taxonomic identifier357244 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeOrientia

Protein attributes

Sequence length590 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 590590Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_1000018081

Regions

Motif138 – 14811"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
A5CD00 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: E1CEDAD95AE61BC4

FASTA59066,606
        10         20         30         40         50         60 
MNIYKRLKQD IDVVATSIIN KLKSTSDSKE FDSLNDTIPI VLESSKDVNS YDISTNIAML 

        70         80         90        100        110        120 
IAKKMNQNSI TLANLFKKKL SHYPYIDNIT IAGPGFINFV ILQEEWTNYL AIILDGSYRK 

       130        140        150        160        170        180 
EYSSIGNNKK VNIEYVSANP TGPLHIGHAR AAVYGDVLAA LLQCTGYQVT REYYVNDTGV 

       190        200        210        220        230        240 
QIDNLAKSVY LRYKQVITGQ VADIPKGLYP GEYLISVGTK LAKEYGDKLL TLSEPEYLNI 

       250        260        270        280        290        300 
IKDVAVNNLL QSIKADLALI GVRHDVFFSE KKLHDSNVIS KVIDLLSVKK LVYTGELSQP 

       310        320        330        340        350        360 
KGQSSDNWQP RSQLLFKSTI FGDNQDRPLQ KEDGSWSYFA SDIAYADNKI KRGFDYVIFI 

       370        380        390        400        410        420 
LGADHIGYVS RIKAIIQALD FNQDITLDIK ICQLVKLIEN GVAVKMSKRS GSFTTIRDVY 

       430        440        450        460        470        480 
EIVGKDVIRF FMLTRKNNAV LDFDLVKLQE QSRDNPVFYV QYAYVRAGSI LRKAKDNANI 

       490        500        510        520        530        540 
AYEIFSTNKS DFSLLSTKEE LNLIKILAVW SHMLDGAVKN FEPHRIAIYL QKLAAEFHAL 

       550        560        570        580        590 
WNLKSNDLDY RFIVLNDNNL TAARLALATA VREIIREGLK IIGITCVEVM 

« Hide

References

[1]"The Orientia tsutsugamushi genome reveals massive proliferation of conjugative type IV secretion system and host-cell interaction genes."
Cho N.-H., Kim H.-R., Lee J.-H., Kim S.-Y., Kim J., Cha S., Kim S.-Y., Darby A.C., Fuxelius H.-H., Yin J., Kim J.H., Kim J., Lee S.J., Koh Y.-S., Jang W.-J., Park K.-H., Andersson S.G.E., Choi M.-S., Kim I.-S.
Proc. Natl. Acad. Sci. U.S.A. 104:7981-7986(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Boryong.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM494475 Genomic DNA. Translation: CAM79637.1.
RefSeqYP_001248422.1. NC_009488.1.

3D structure databases

ProteinModelPortalA5CD00.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING357244.OTBS_0571.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAM79637; CAM79637; OTBS_0571.
GeneID5218908.
KEGGots:OTBS_0571.
PATRIC22822380. VBIOriTsu83812_0612.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247214.
KOK01887.
OMAPRVKGAI.
OrthoDBEOG6JB13C.

Enzyme and pathway databases

BioCycOTSU357244:GCA5-590-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_ORITB
AccessionPrimary (citable) accession number: A5CD00
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 12, 2007
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries