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A5CCT4

- SYL_ORITB

UniProt

A5CCT4 - SYL_ORITB

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Protein
Leucine--tRNA ligase
Gene
leuS, OTBS_0468
Organism
Orientia tsutsugamushi (strain Boryong) (Rickettsia tsutsugamushi)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei611 – 6111ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciOTSU357244:GCA5-482-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:OTBS_0468
OrganismiOrientia tsutsugamushi (strain Boryong) (Rickettsia tsutsugamushi)
Taxonomic identifieri357244 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeOrientia
ProteomesiUP000001565: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 838838Leucine--tRNA ligaseUniRule annotation
PRO_0000334786Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi357244.OTBS_0468.

Structurei

3D structure databases

ProteinModelPortaliA5CCT4.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi38 – 4811"HIGH" regionUniRule annotation
Add
BLAST
Motifi608 – 6125"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiPVIHCPK.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

A5CCT4-1 [UniParc]FASTAAdd to Basket

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MNLVKIEKKW QKIWEQNEVF KVKEILNKIK RYILPMFPYP SGKAHVGHVR    50
NYTICDVIAR FERSQGHNVL HAMGWDAFGL PAENAAMQNN TYPNSWVSSN 100
VDVMRQQLKA IGLSYDWSRE IITCSSQYYV HEQRFFLEML KKGLVYQKES 150
LVNWDPIDQT VLANEQVING KGWRSGAIIE YRNLKQWFIK ITNYADALLK 200
GLDSLKGWPE SVKTMQKKWI GQSTGININF QLKGIEASVK VFSTRPETLF 250
GASFIALSYN HNLVQQYVNT TPETQKFIDK CSNVGTSNVN IDKMKIAVLT 300
NLKVIHPLNS SIELPVILSN FVLMDYGTGA LFGCPAHDER DHEIAKLLKL 350
NIKQVITSTE RNIDVLKEAY VGDGIMINSF HLNGLTTTEA RQKVINELQH 400
KNIGQQVTNY KLKDWGISRQ RFWGCPIPII HCKSCGAVPV PYEDLPVILP 450
EHGVEFTGKG NPLDNHHSWK YVKCPKCHLD AVRETDTFDT FFESSWYFAR 500
FCNPTSDDMV DAKAAKYWLP VDQYIGGIEH AVMHLLYARF ITRVMYDLKY 550
IDIQEPFTSL ITQGMVLHRT YQDKSNNWLY PNEVEVDSNG QLRCKADLQY 600
VTVGKLEKMS KSKKNVVDLE LVLKLYGADV ARMFVLSDTP PEKDLEWSTE 650
GIEGCYKFIQ KLYNFALKLK NINLTDNKID KVLLSKTHKT IKNVTQDIIS 700
CRLNKAIARL RELYNLIFKM SELTVQIKES FLILIRLFNP FIPHLSEEIW 750
SLLSGRGEML VELPWPKYEE KYIHEEEHIT IAIQINGKLR SLYNCLIDTP 800
EHDVQSAILK LEQVKKHIGD KEVRKCIFVP NKLINIII 838
Length:838
Mass (Da):96,655
Last modified:June 12, 2007 - v1
Checksum:iF8757CA6ACA4175C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM494475 Genomic DNA. Translation: CAM79534.1.
RefSeqiWP_011944500.1. NC_009488.1.
YP_001248365.1. NC_009488.1.

Genome annotation databases

EnsemblBacteriaiCAM79534; CAM79534; OTBS_0468.
GeneIDi5218800.
KEGGiots:OTBS_0468.
PATRICi22822144. VBIOriTsu83812_0499.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM494475 Genomic DNA. Translation: CAM79534.1 .
RefSeqi WP_011944500.1. NC_009488.1.
YP_001248365.1. NC_009488.1.

3D structure databases

ProteinModelPortali A5CCT4.
ModBasei Search...

Protein-protein interaction databases

STRINGi 357244.OTBS_0468.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAM79534 ; CAM79534 ; OTBS_0468 .
GeneIDi 5218800.
KEGGi ots:OTBS_0468.
PATRICi 22822144. VBIOriTsu83812_0499.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi PVIHCPK.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci OTSU357244:GCA5-482-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The Orientia tsutsugamushi genome reveals massive proliferation of conjugative type IV secretion system and host-cell interaction genes."
    Cho N.-H., Kim H.-R., Lee J.-H., Kim S.-Y., Kim J., Cha S., Kim S.-Y., Darby A.C., Fuxelius H.-H., Yin J., Kim J.H., Kim J., Lee S.J., Koh Y.-S., Jang W.-J., Park K.-H., Andersson S.G.E., Choi M.-S., Kim I.-S.
    Proc. Natl. Acad. Sci. U.S.A. 104:7981-7986(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Boryong.

Entry informationi

Entry nameiSYL_ORITB
AccessioniPrimary (citable) accession number: A5CCT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: September 3, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi