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A5CCT4

- SYL_ORITB

UniProt

A5CCT4 - SYL_ORITB

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Orientia tsutsugamushi (strain Boryong) (Rickettsia tsutsugamushi)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei611 – 6111ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciOTSU357244:GCA5-482-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:OTBS_0468
    OrganismiOrientia tsutsugamushi (strain Boryong) (Rickettsia tsutsugamushi)
    Taxonomic identifieri357244 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeOrientia
    ProteomesiUP000001565: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 838838Leucine--tRNA ligasePRO_0000334786Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi357244.OTBS_0468.

    Structurei

    3D structure databases

    ProteinModelPortaliA5CCT4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi38 – 4811"HIGH" regionAdd
    BLAST
    Motifi608 – 6125"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiPVIHCPK.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A5CCT4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNLVKIEKKW QKIWEQNEVF KVKEILNKIK RYILPMFPYP SGKAHVGHVR    50
    NYTICDVIAR FERSQGHNVL HAMGWDAFGL PAENAAMQNN TYPNSWVSSN 100
    VDVMRQQLKA IGLSYDWSRE IITCSSQYYV HEQRFFLEML KKGLVYQKES 150
    LVNWDPIDQT VLANEQVING KGWRSGAIIE YRNLKQWFIK ITNYADALLK 200
    GLDSLKGWPE SVKTMQKKWI GQSTGININF QLKGIEASVK VFSTRPETLF 250
    GASFIALSYN HNLVQQYVNT TPETQKFIDK CSNVGTSNVN IDKMKIAVLT 300
    NLKVIHPLNS SIELPVILSN FVLMDYGTGA LFGCPAHDER DHEIAKLLKL 350
    NIKQVITSTE RNIDVLKEAY VGDGIMINSF HLNGLTTTEA RQKVINELQH 400
    KNIGQQVTNY KLKDWGISRQ RFWGCPIPII HCKSCGAVPV PYEDLPVILP 450
    EHGVEFTGKG NPLDNHHSWK YVKCPKCHLD AVRETDTFDT FFESSWYFAR 500
    FCNPTSDDMV DAKAAKYWLP VDQYIGGIEH AVMHLLYARF ITRVMYDLKY 550
    IDIQEPFTSL ITQGMVLHRT YQDKSNNWLY PNEVEVDSNG QLRCKADLQY 600
    VTVGKLEKMS KSKKNVVDLE LVLKLYGADV ARMFVLSDTP PEKDLEWSTE 650
    GIEGCYKFIQ KLYNFALKLK NINLTDNKID KVLLSKTHKT IKNVTQDIIS 700
    CRLNKAIARL RELYNLIFKM SELTVQIKES FLILIRLFNP FIPHLSEEIW 750
    SLLSGRGEML VELPWPKYEE KYIHEEEHIT IAIQINGKLR SLYNCLIDTP 800
    EHDVQSAILK LEQVKKHIGD KEVRKCIFVP NKLINIII 838
    Length:838
    Mass (Da):96,655
    Last modified:June 12, 2007 - v1
    Checksum:iF8757CA6ACA4175C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM494475 Genomic DNA. Translation: CAM79534.1.
    RefSeqiWP_011944500.1. NC_009488.1.
    YP_001248365.1. NC_009488.1.

    Genome annotation databases

    EnsemblBacteriaiCAM79534; CAM79534; OTBS_0468.
    GeneIDi5218800.
    KEGGiots:OTBS_0468.
    PATRICi22822144. VBIOriTsu83812_0499.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM494475 Genomic DNA. Translation: CAM79534.1 .
    RefSeqi WP_011944500.1. NC_009488.1.
    YP_001248365.1. NC_009488.1.

    3D structure databases

    ProteinModelPortali A5CCT4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 357244.OTBS_0468.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAM79534 ; CAM79534 ; OTBS_0468 .
    GeneIDi 5218800.
    KEGGi ots:OTBS_0468.
    PATRICi 22822144. VBIOriTsu83812_0499.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi PVIHCPK.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci OTSU357244:GCA5-482-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The Orientia tsutsugamushi genome reveals massive proliferation of conjugative type IV secretion system and host-cell interaction genes."
      Cho N.-H., Kim H.-R., Lee J.-H., Kim S.-Y., Kim J., Cha S., Kim S.-Y., Darby A.C., Fuxelius H.-H., Yin J., Kim J.H., Kim J., Lee S.J., Koh Y.-S., Jang W.-J., Park K.-H., Andersson S.G.E., Choi M.-S., Kim I.-S.
      Proc. Natl. Acad. Sci. U.S.A. 104:7981-7986(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Boryong.

    Entry informationi

    Entry nameiSYL_ORITB
    AccessioniPrimary (citable) accession number: A5CCT4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3