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A5CC62

- PNP_ORITB

UniProt

A5CC62 - PNP_ORITB

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, OTBS_0162
Organism
Orientia tsutsugamushi (strain Boryong) (Rickettsia tsutsugamushi)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi492 – 4921Magnesium By similarity
Metal bindingi498 – 4981Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciOTSU357244:GCA5-165-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:OTBS_0162
OrganismiOrientia tsutsugamushi (strain Boryong) (Rickettsia tsutsugamushi)
Taxonomic identifieri357244 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeOrientia
ProteomesiUP000001565: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 740740Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_0000329746Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi357244.OTBS_0162.

Structurei

3D structure databases

ProteinModelPortaliA5CC62.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini559 – 61860KH
Add
BLAST
Domaini628 – 69669S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiHGNFKSN.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5CC62-1 [UniParc]FASTAAdd to Basket

« Hide

MFNEILKKVD WHGNVLSLST GKIARNADGA VLASMGNTSV LCTVVFDKNT    50
KKDMDFFPLG VYYREMAYAA GKIPGGFIKK EGKFSEYEVL VSRLIDRSIR 100
PLFDSNFRND TQIICTVMSY DPRYSPDILA IIGSSAALAI SGIPIVKPIG 150
AARVGIVNDE FILNPVIHDN TGVNELDLVV AATFDSVTMI EAQACEIDEE 200
KMLAAIEFGY KSLKPVINAI EEIKSSIRKD IFEVTARPHL RYNDEILKHF 250
SSDIKSALLL QTKNERNQQL QLIQQKVIDY FSSKANSEAN DGDDILNIEK 300
ALDDAKSKIF RDLVLQNKTR IGNRAVDEIR PIICEAGLFN TVHGSALFTR 350
GDTQSLATIT LGSSTDEQIV EQLNKCERQN FLLDYIFLPY SVGEISPLRA 400
ASRREIGHGW LAKKAIQLVI PSKDVFPYTI RIVSEITQSD GSSSMATVCS 450
ASLSLMEAGV PIKTHVAGIA MGLVLGEGNK FEILSDISGC EDHLGDMDFK 500
VASTKNGITA LQLDIKVQGI NLSMIESTFR QAKIGINHIL NVMNNTISCP 550
KSELSTYAPM VQTLEIQKEK IRDVIGLGGK VIKELCKTFD VEIDISENGE 600
VKVWGNVGEN VKKAVQSIEN IVFVPQIGDI FDGEVVKVIE SGAFIKYVTG 650
RDGFVHISEI NDTHIKDINA HVKLGDKVKV KIIGIDHKNR VKLTLRTDKE 700
HCKNKNEQYN DITTTTGGVK KKIKIAPKEA AVISNRKYFD 740
Length:740
Mass (Da):81,783
Last modified:June 12, 2007 - v1
Checksum:iC75060B6EC8AA41D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM494475 Genomic DNA. Translation: CAM79228.1.
RefSeqiWP_011944308.1. NC_009488.1.
YP_001248172.1. NC_009488.1.

Genome annotation databases

EnsemblBacteriaiCAM79228; CAM79228; OTBS_0162.
GeneIDi5218483.
KEGGiots:OTBS_0162.
PATRICi22821490. VBIOriTsu83812_0183.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM494475 Genomic DNA. Translation: CAM79228.1 .
RefSeqi WP_011944308.1. NC_009488.1.
YP_001248172.1. NC_009488.1.

3D structure databases

ProteinModelPortali A5CC62.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 357244.OTBS_0162.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAM79228 ; CAM79228 ; OTBS_0162 .
GeneIDi 5218483.
KEGGi ots:OTBS_0162.
PATRICi 22821490. VBIOriTsu83812_0183.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi HGNFKSN.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci OTSU357244:GCA5-165-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The Orientia tsutsugamushi genome reveals massive proliferation of conjugative type IV secretion system and host-cell interaction genes."
    Cho N.-H., Kim H.-R., Lee J.-H., Kim S.-Y., Kim J., Cha S., Kim S.-Y., Darby A.C., Fuxelius H.-H., Yin J., Kim J.H., Kim J., Lee S.J., Koh Y.-S., Jang W.-J., Park K.-H., Andersson S.G.E., Choi M.-S., Kim I.-S.
    Proc. Natl. Acad. Sci. U.S.A. 104:7981-7986(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Boryong.

Entry informationi

Entry nameiPNP_ORITB
AccessioniPrimary (citable) accession number: A5CC62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 12, 2007
Last modified: September 3, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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