Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Orientia tsutsugamushi (strain Boryong) (Rickettsia tsutsugamushi)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi492MagnesiumUniRule annotation1
Metal bindingi498MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciOTSU357244:G1GJM-168-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:OTBS_0162
OrganismiOrientia tsutsugamushi (strain Boryong) (Rickettsia tsutsugamushi)
Taxonomic identifieri357244 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeOrientia
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003297461 – 740Polyribonucleotide nucleotidyltransferaseAdd BLAST740

Proteomic databases

PRIDEiA5CC62

Interactioni

Protein-protein interaction databases

STRINGi357244.OTBS_0162

Structurei

3D structure databases

ProteinModelPortaliA5CC62
SMRiA5CC62
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini559 – 618KHUniRule annotationAdd BLAST60
Domaini628 – 696S1 motifUniRule annotationAdd BLAST69

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62 Bacteria
COG1185 LUCA
HOGENOMiHOG000218326
KOiK00962
OMAiRYMHNYN
OrthoDBiPOG091H00M0

Family and domain databases

Gene3Di3.30.1370.10, 1 hit
3.30.230.70, 2 hits
HAMAPiMF_01595 PNPase, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR015847 ExoRNase_PH_dom2
IPR036345 ExoRNase_PH_dom2_sf
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012340 NA-bd_OB-fold
IPR012162 PNPase
IPR027408 PNPase/RNase_PH_dom_sf
IPR015848 PNPase_PH_RNA-bd_bac/org-type
IPR036456 PNPase_PH_RNA-bd_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR022967 S1_dom
IPR003029 S1_domain
PANTHERiPTHR11252 PTHR11252, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
PF03726 PNPase, 1 hit
PF01138 RNase_PH, 2 hits
PF03725 RNase_PH_C, 1 hit
PF00575 S1, 1 hit
PIRSFiPIRSF005499 PNPase, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SM00316 S1, 1 hit
SUPFAMiSSF46915 SSF46915, 1 hit
SSF50249 SSF50249, 1 hit
SSF54211 SSF54211, 2 hits
SSF54791 SSF54791, 1 hit
SSF55666 SSF55666, 2 hits
TIGRFAMsiTIGR03591 polynuc_phos, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

A5CC62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFNEILKKVD WHGNVLSLST GKIARNADGA VLASMGNTSV LCTVVFDKNT
60 70 80 90 100
KKDMDFFPLG VYYREMAYAA GKIPGGFIKK EGKFSEYEVL VSRLIDRSIR
110 120 130 140 150
PLFDSNFRND TQIICTVMSY DPRYSPDILA IIGSSAALAI SGIPIVKPIG
160 170 180 190 200
AARVGIVNDE FILNPVIHDN TGVNELDLVV AATFDSVTMI EAQACEIDEE
210 220 230 240 250
KMLAAIEFGY KSLKPVINAI EEIKSSIRKD IFEVTARPHL RYNDEILKHF
260 270 280 290 300
SSDIKSALLL QTKNERNQQL QLIQQKVIDY FSSKANSEAN DGDDILNIEK
310 320 330 340 350
ALDDAKSKIF RDLVLQNKTR IGNRAVDEIR PIICEAGLFN TVHGSALFTR
360 370 380 390 400
GDTQSLATIT LGSSTDEQIV EQLNKCERQN FLLDYIFLPY SVGEISPLRA
410 420 430 440 450
ASRREIGHGW LAKKAIQLVI PSKDVFPYTI RIVSEITQSD GSSSMATVCS
460 470 480 490 500
ASLSLMEAGV PIKTHVAGIA MGLVLGEGNK FEILSDISGC EDHLGDMDFK
510 520 530 540 550
VASTKNGITA LQLDIKVQGI NLSMIESTFR QAKIGINHIL NVMNNTISCP
560 570 580 590 600
KSELSTYAPM VQTLEIQKEK IRDVIGLGGK VIKELCKTFD VEIDISENGE
610 620 630 640 650
VKVWGNVGEN VKKAVQSIEN IVFVPQIGDI FDGEVVKVIE SGAFIKYVTG
660 670 680 690 700
RDGFVHISEI NDTHIKDINA HVKLGDKVKV KIIGIDHKNR VKLTLRTDKE
710 720 730 740
HCKNKNEQYN DITTTTGGVK KKIKIAPKEA AVISNRKYFD
Length:740
Mass (Da):81,783
Last modified:June 12, 2007 - v1
Checksum:iC75060B6EC8AA41D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM494475 Genomic DNA Translation: CAM79228.1
RefSeqiWP_011944308.1, NC_009488.1

Genome annotation databases

EnsemblBacteriaiCAM79228; CAM79228; OTBS_0162
GeneIDi29642965
KEGGiots:OTBS_0162

Similar proteinsi

Entry informationi

Entry nameiPNP_ORITB
AccessioniPrimary (citable) accession number: A5CC62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 12, 2007
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health