Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable cutinase 2

Gene

An11g00110

Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of cutin, a polyester that forms the structure of plant cuticle.By similarity

Catalytic activityi

Cutin + H2O = cutin monomers.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei126PROSITE-ProRule annotation1
Active sitei181PROSITE-ProRule annotation1
Active sitei194PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Protein family/group databases

ESTHERiaspnc-cuti2. Cutinase.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cutinase 2 (EC:3.1.1.74)
Alternative name(s):
Cutin hydrolase 2
Gene namesi
ORF Names:An11g00110
OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)
Taxonomic identifieri425011 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006706 Componenti: Chromosome 7R

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_500024239317 – 271Probable cutinase 2Add BLAST255

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 184By similarity
Disulfide bondi115 ↔ 177By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliA5ABE6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi210 – 269Ser-richAdd BLAST60

Sequence similaritiesi

Belongs to the cutinase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000171425.
KOiK08095.
OrthoDBiEOG092C4OIR.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000675. Cutinase/axe.
IPR011150. Cutinase_monf.
[Graphical view]
PfamiPF01083. Cutinase. 1 hit.
[Graphical view]
PRINTSiPR00129. CUTINASE.
SMARTiSM01110. Cutinase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00931. CUTINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A5ABE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLPYFLLGL AGLAAASPMG LAERQLSDGN ELRDGSCKPI IFIFARASTE
60 70 80 90 100
PGLLGISTGP AVCNDLKMAK AGQVLCQGVG PAYTADLMSN ALPDNTSPAA
110 120 130 140 150
ISESESLFKL AASKCPNSQI LAGGYSQGTA VMDDSIKQLP DDVKDKIKGV
160 170 180 190 200
VLFGYTRNAQ EGGQIGNFPK DKVKIYCAMG DLVCDGTLIV TAAHFTYVMN
210 220 230 240 250
TGEASQWLES KLSDTTTSSL TGSSSSDTSS STSTGDSSSE SSSAAGLGGL
260 270
SGLTGLGSST SGGFPSLASL F
Length:271
Mass (Da):27,628
Last modified:June 12, 2007 - v1
Checksum:i90A73A60C15B1E5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM270218 Genomic DNA. Translation: CAK48244.1.
RefSeqiXP_001394015.1. XM_001393978.1.

Genome annotation databases

EnsemblFungiiCAK48244; CAK48244; An11g00110.
GeneIDi4984242.
KEGGiang:ANI_1_1504094.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM270218 Genomic DNA. Translation: CAK48244.1.
RefSeqiXP_001394015.1. XM_001393978.1.

3D structure databases

ProteinModelPortaliA5ABE6.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERiaspnc-cuti2. Cutinase.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAK48244; CAK48244; An11g00110.
GeneIDi4984242.
KEGGiang:ANI_1_1504094.

Phylogenomic databases

HOGENOMiHOG000171425.
KOiK08095.
OrthoDBiEOG092C4OIR.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000675. Cutinase/axe.
IPR011150. Cutinase_monf.
[Graphical view]
PfamiPF01083. Cutinase. 1 hit.
[Graphical view]
PRINTSiPR00129. CUTINASE.
SMARTiSM01110. Cutinase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00931. CUTINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCUTI2_ASPNC
AccessioniPrimary (citable) accession number: A5ABE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: June 12, 2007
Last modified: November 30, 2016
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.