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A5A779

- PGTA_PIG

UniProt

A5A779 - PGTA_PIG

Protein

Geranylgeranyl transferase type-2 subunit alpha

Gene

RABGGTA

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.By similarity

    Catalytic activityi

    Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

    Enzyme regulationi

    The enzymatic reaction requires the aid of a Rab escort protein (also called component A), such as CHM.By similarity

    GO - Molecular functioni

    1. Rab geranylgeranyltransferase activity Source: UniProtKB
    2. Rab GTPase binding Source: UniProtKB
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. protein geranylgeranylation Source: UniProtKB

    Keywords - Molecular functioni

    Prenyltransferase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Geranylgeranyl transferase type-2 subunit alpha (EC:2.5.1.60)
    Alternative name(s):
    Geranylgeranyl transferase type II subunit alpha
    Rab geranyl-geranyltransferase subunit alpha
    Short name:
    Rab GG transferase alpha
    Short name:
    Rab GGTase alpha
    Rab geranylgeranyltransferase subunit alpha
    Gene namesi
    Name:RABGGTA
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Chromosome 7

    Subcellular locationi

    GO - Cellular componenti

    1. Rab-protein geranylgeranyltransferase complex Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 567567Geranylgeranyl transferase type-2 subunit alphaPRO_0000331286Add
    BLAST

    Proteomic databases

    PaxDbiA5A779.

    Interactioni

    Subunit structurei

    Heterotrimer composed of RABGGTA, RABGGTB and CHM; within this trimer, RABGGTA and RABGGTB form the catalytic component B, while CHM (component A) mediates peptide substrate binding. The Rab GGTase dimer (RGGT) interacts with CHM (component A) prior to Rab protein binding; the association is stabilized by geranylgeranyl pyrophosphate (GGpp). The CHM:RGGT:Rab complex is destabilized by GGpp By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9823.ENSSSCP00000002178.

    Structurei

    3D structure databases

    ProteinModelPortaliA5A779.
    SMRiA5A779. Positions 2-567.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati44 – 7835PFTA 1Add
    BLAST
    Repeati88 – 12235PFTA 2Add
    BLAST
    Repeati124 – 15835PFTA 3Add
    BLAST
    Repeati159 – 19335PFTA 4Add
    BLAST
    Repeati207 – 24135PFTA 5Add
    BLAST
    Repeati363 – 39735PFTA 6Add
    BLAST
    Repeati442 – 46322LRR 1Add
    BLAST
    Repeati464 – 48623LRR 2Add
    BLAST
    Repeati487 – 50822LRR 3Add
    BLAST
    Repeati509 – 53022LRR 4Add
    BLAST
    Repeati534 – 55522LRR 5Add
    BLAST

    Sequence similaritiesi

    Contains 5 LRR (leucine-rich) repeats.Curated
    Contains 6 PFTA repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Leucine-rich repeat, Repeat

    Phylogenomic databases

    eggNOGiCOG5536.
    GeneTreeiENSGT00550000075121.
    HOGENOMiHOG000007845.
    HOVERGENiHBG002171.
    KOiK14050.
    OMAiWNCRREV.
    OrthoDBiEOG7PP56C.
    TreeFamiTF315057.

    Family and domain databases

    Gene3Di2.60.40.1130. 1 hit.
    InterProiIPR001611. Leu-rich_rpt.
    IPR025875. Leu-rich_rpt_4.
    IPR002088. Prenyl_trans_a.
    IPR009087. RabGGT_asu_insert-domain.
    [Graphical view]
    PfamiPF00560. LRR_1. 1 hit.
    PF12799. LRR_4. 1 hit.
    PF01239. PPTA. 5 hits.
    PF07711. RabGGT_insert. 1 hit.
    [Graphical view]
    ProDomiPD331837. RabGG_trans_A. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF49594. SSF49594. 1 hit.
    PROSITEiPS51147. PFTA. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5A779-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHGRLKVKTS EEQAEAKRLE REQKLKLYQT ATQTVFQKRQ AGELDESVLE    50
    LTSQILGANP DFATLWNCRR EVLQRLEVQK SPEELAALVK AELGFLESCL 100
    RVNPKSYGTW HHRCWLLGRL PEPNWARELE LCARFLEVDE RNFHCWDYRR 150
    FVASQAAVPP AEELAFTDSL ITRNFSNYSS WHYRSCLLPQ LHPQPDSGPQ 200
    GRLPEDVLLK ELELVQNAFF TDPNDQSAWF YHRWLLGRAD PQDALRCLHV 250
    SRDEACLTVS FSRPLLVGPS TETLLLMVNE SPLSVEWRTP DGRNRPSHVW 300
    LCDLPAASLN DHLPQHTFRV IWTAGNAQKE CVLLKGRQEG WCRDSATDEQ 350
    LFRCELSVEK STVLQSELES CKELQELEPE NKWCLLTIIL LMRALDPLLY 400
    EKETLQYFQT LKAVDPMRAA YLDDLRSKFL LENSVLKMEY ADVRVLHLGH 450
    KDLTVLCHLE QLLLVTHLDL SHNRLRALPP ALAALRCLEV LQANDNAIES 500
    LDGVTNLPRL QELSLCNNRL QQPAVLQPLA SCPRLVLLNL QDNPLCQAVG 550
    ISEHLAELLP SVSSILT 567
    Length:567
    Mass (Da):64,901
    Last modified:June 12, 2007 - v1
    Checksum:i79BFCA2DD50C4F97
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB271949 mRNA. Translation: BAF62324.1.
    RefSeqiNP_001092063.1. NM_001098593.1.
    XP_005666280.1. XM_005666223.1.
    UniGeneiSsc.45681.

    Genome annotation databases

    EnsembliENSSSCT00000002230; ENSSSCP00000002178; ENSSSCG00000001992.
    GeneIDi100049679.
    KEGGissc:100049679.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB271949 mRNA. Translation: BAF62324.1 .
    RefSeqi NP_001092063.1. NM_001098593.1.
    XP_005666280.1. XM_005666223.1.
    UniGenei Ssc.45681.

    3D structure databases

    ProteinModelPortali A5A779.
    SMRi A5A779. Positions 2-567.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9823.ENSSSCP00000002178.

    Proteomic databases

    PaxDbi A5A779.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSSSCT00000002230 ; ENSSSCP00000002178 ; ENSSSCG00000001992 .
    GeneIDi 100049679.
    KEGGi ssc:100049679.

    Organism-specific databases

    CTDi 5875.

    Phylogenomic databases

    eggNOGi COG5536.
    GeneTreei ENSGT00550000075121.
    HOGENOMi HOG000007845.
    HOVERGENi HBG002171.
    KOi K14050.
    OMAi WNCRREV.
    OrthoDBi EOG7PP56C.
    TreeFami TF315057.

    Family and domain databases

    Gene3Di 2.60.40.1130. 1 hit.
    InterProi IPR001611. Leu-rich_rpt.
    IPR025875. Leu-rich_rpt_4.
    IPR002088. Prenyl_trans_a.
    IPR009087. RabGGT_asu_insert-domain.
    [Graphical view ]
    Pfami PF00560. LRR_1. 1 hit.
    PF12799. LRR_4. 1 hit.
    PF01239. PPTA. 5 hits.
    PF07711. RabGGT_insert. 1 hit.
    [Graphical view ]
    ProDomi PD331837. RabGG_trans_A. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF49594. SSF49594. 1 hit.
    PROSITEi PS51147. PFTA. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequences and genetic variations of fourty-four porcine coat color related genes."
      Okumura N., Matsumoto T., Hamasima N., Uenishi H., Ogawa T., Komatsuda A., Fukudome N., Ide H., Suzuki A., Kojima C., Awata T.
      Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiPGTA_PIG
    AccessioniPrimary (citable) accession number: A5A779
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3