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Protein

Endothelin-3

Gene

EDN3

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Endothelins are endothelium-derived vasoconstrictor peptides.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Vasoactive, Vasoconstrictor

Enzyme and pathway databases

ReactomeiR-SSC-375276. Peptide ligand-binding receptors.
R-SSC-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-3
Short name:
ET-3
Alternative name(s):
Preproendothelin-3
Short name:
PPET3
Gene namesi
Name:EDN3
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 17

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
PropeptideiPRO_000029639318 – 80Add BLAST63
PeptideiPRO_000029639483 – 103Endothelin-3Add BLAST21
PropeptideiPRO_0000296395104 – 204Add BLAST101

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi83 ↔ 97By similarity
Disulfide bondi85 ↔ 93By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei103 – 104Cleavage; by KELBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiA5A752.
PRIDEiA5A752.

Expressioni

Gene expression databases

BgeeiENSSSCG00000007527.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000008036.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni144 – 158Endothelin-likeAdd BLAST15

Sequence similaritiesi

Belongs to the endothelin/sarafotoxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXXK. Eukaryota.
ENOG410YW48. LUCA.
GeneTreeiENSGT00530000063310.
HOGENOMiHOG000231110.
HOVERGENiHBG051442.
InParanoidiA5A752.
KOiK05227.
OMAiRSRRCTC.
OrthoDBiEOG091G0OPZ.
TreeFamiTF333184.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A5A752-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELRLWFLFG LTVTSAAGPV PRPQPGDAGR SGVPRAPSAT KETMAMVATR
60 70 80 90 100
GPSPRSSGQE QEPGPFGELA AKGGPVRYRA RRCTCFTYKD KECVYYCHLD
110 120 130 140 150
IIWINTPERT VPYGLSNHRG SVRGRRSAGP SPQSSQPSRG TLRCACAESQ
160 170 180 190 200
DRACVYFCTR TLAARGASRT PETPDKEAGK PAGRATGGLH PRRLKSRTDK

ARRL
Length:204
Mass (Da):22,190
Last modified:June 12, 2007 - v1
Checksum:iB66A33C4E19C7662
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB271922 mRNA. Translation: BAF62297.1.
CR956624 Genomic DNA. Translation: CAN13224.1.
RefSeqiNP_001092052.1. NM_001098582.2.
UniGeneiSsc.31972.

Genome annotation databases

EnsembliENSSSCT00000008255; ENSSSCP00000008036; ENSSSCG00000007527.
GeneIDi100049663.
KEGGissc:100049663.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB271922 mRNA. Translation: BAF62297.1.
CR956624 Genomic DNA. Translation: CAN13224.1.
RefSeqiNP_001092052.1. NM_001098582.2.
UniGeneiSsc.31972.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000008036.

Proteomic databases

PaxDbiA5A752.
PRIDEiA5A752.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000008255; ENSSSCP00000008036; ENSSSCG00000007527.
GeneIDi100049663.
KEGGissc:100049663.

Organism-specific databases

CTDi1908.

Phylogenomic databases

eggNOGiENOG410IXXK. Eukaryota.
ENOG410YW48. LUCA.
GeneTreeiENSGT00530000063310.
HOGENOMiHOG000231110.
HOVERGENiHBG051442.
InParanoidiA5A752.
KOiK05227.
OMAiRSRRCTC.
OrthoDBiEOG091G0OPZ.
TreeFamiTF333184.

Enzyme and pathway databases

ReactomeiR-SSC-375276. Peptide ligand-binding receptors.
R-SSC-416476. G alpha (q) signalling events.

Gene expression databases

BgeeiENSSSCG00000007527.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEDN3_PIG
AccessioniPrimary (citable) accession number: A5A752
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: June 12, 2007
Last modified: November 2, 2016
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.