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Protein

Endothelin-3

Gene

EDN3

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Endothelins are endothelium-derived vasoconstrictor peptides.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei103 – 1042Cleavage; by KELBy similarity

GO - Biological processi

  1. cell surface receptor signaling pathway Source: Ensembl
  2. cellular calcium ion homeostasis Source: Ensembl
  3. cellular magnesium ion homeostasis Source: Ensembl
  4. inositol phosphate-mediated signaling Source: Ensembl
  5. melanocyte differentiation Source: Ensembl
  6. neural crest cell migration Source: Ensembl
  7. neuron differentiation Source: Ensembl
  8. neutrophil chemotaxis Source: Ensembl
  9. peptide hormone secretion Source: Ensembl
  10. positive regulation of cell proliferation Source: Ensembl
  11. positive regulation of heart rate Source: Ensembl
  12. positive regulation of hormone secretion Source: Ensembl
  13. positive regulation of leukocyte chemotaxis Source: Ensembl
  14. positive regulation of MAP kinase activity Source: Ensembl
  15. positive regulation of mitosis Source: Ensembl
  16. positive regulation of potassium ion transmembrane transport Source: Ensembl
  17. regulation of developmental pigmentation Source: Ensembl
  18. regulation of systemic arterial blood pressure by endothelin Source: Ensembl
  19. regulation of vasoconstriction Source: InterPro
  20. vein smooth muscle contraction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Vasoactive, Vasoconstrictor

Enzyme and pathway databases

ReactomeiREACT_204540. Peptide ligand-binding receptors.
REACT_251517. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-3
Short name:
ET-3
Alternative name(s):
Preproendothelin-3
Short name:
PPET3
Gene namesi
Name:EDN3
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Chromosome 17

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Propeptidei18 – 8063PRO_0000296393Add
BLAST
Peptidei83 – 10321Endothelin-3PRO_0000296394Add
BLAST
Propeptidei104 – 204101PRO_0000296395Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi83 ↔ 97By similarity
Disulfide bondi85 ↔ 93By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000008036.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni144 – 15815Endothelin-likeAdd
BLAST

Sequence similaritiesi

Belongs to the endothelin/sarafotoxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG41573.
GeneTreeiENSGT00530000063310.
HOGENOMiHOG000231110.
HOVERGENiHBG051442.
InParanoidiA5A752.
KOiK05227.
OMAiHHRSRRC.
OrthoDBiEOG7PCJHP.
TreeFamiTF333184.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A5A752-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELRLWFLFG LTVTSAAGPV PRPQPGDAGR SGVPRAPSAT KETMAMVATR
60 70 80 90 100
GPSPRSSGQE QEPGPFGELA AKGGPVRYRA RRCTCFTYKD KECVYYCHLD
110 120 130 140 150
IIWINTPERT VPYGLSNHRG SVRGRRSAGP SPQSSQPSRG TLRCACAESQ
160 170 180 190 200
DRACVYFCTR TLAARGASRT PETPDKEAGK PAGRATGGLH PRRLKSRTDK

ARRL
Length:204
Mass (Da):22,190
Last modified:June 12, 2007 - v1
Checksum:iB66A33C4E19C7662
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB271922 mRNA. Translation: BAF62297.1.
CR956624 Genomic DNA. Translation: CAN13224.1.
RefSeqiNP_001092052.1. NM_001098582.2.
UniGeneiSsc.31972.

Genome annotation databases

EnsembliENSSSCT00000008255; ENSSSCP00000008036; ENSSSCG00000007527.
GeneIDi100049663.
KEGGissc:100049663.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB271922 mRNA. Translation: BAF62297.1.
CR956624 Genomic DNA. Translation: CAN13224.1.
RefSeqiNP_001092052.1. NM_001098582.2.
UniGeneiSsc.31972.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000008036.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000008255; ENSSSCP00000008036; ENSSSCG00000007527.
GeneIDi100049663.
KEGGissc:100049663.

Organism-specific databases

CTDi1908.

Phylogenomic databases

eggNOGiNOG41573.
GeneTreeiENSGT00530000063310.
HOGENOMiHOG000231110.
HOVERGENiHBG051442.
InParanoidiA5A752.
KOiK05227.
OMAiHHRSRRC.
OrthoDBiEOG7PCJHP.
TreeFamiTF333184.

Enzyme and pathway databases

ReactomeiREACT_204540. Peptide ligand-binding receptors.
REACT_251517. G alpha (q) signalling events.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequences and genetic variations of forty-four porcine coat color related genes."
    Okumura N., Matsumoto T., Hamasima N., Uenishi H., Ogawa T., Komatsuda A., Fukudome N., Ide H., Suzuki A., Kojima C., Awata T.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Porcine genome sequencing project
    Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiEDN3_PIG
AccessioniPrimary (citable) accession number: A5A752
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: June 12, 2007
Last modified: March 4, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.