Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A5A752

- EDN3_PIG

UniProt

A5A752 - EDN3_PIG

Protein

Endothelin-3

Gene

EDN3

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Endothelins are endothelium-derived vasoconstrictor peptides.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei103 – 1042Cleavage; by KELBy similarity

    GO - Biological processi

    1. cell surface receptor signaling pathway Source: Ensembl
    2. inositol phosphate-mediated signaling Source: Ensembl
    3. melanocyte differentiation Source: Ensembl
    4. neural crest cell migration Source: Ensembl
    5. neuron differentiation Source: Ensembl
    6. neutrophil chemotaxis Source: Ensembl
    7. peptide hormone secretion Source: Ensembl
    8. positive regulation of cell proliferation Source: Ensembl
    9. positive regulation of heart rate Source: Ensembl
    10. positive regulation of hormone secretion Source: Ensembl
    11. positive regulation of leukocyte chemotaxis Source: Ensembl
    12. positive regulation of MAP kinase activity Source: Ensembl
    13. positive regulation of mitosis Source: Ensembl
    14. regulation of developmental pigmentation Source: Ensembl
    15. regulation of systemic arterial blood pressure by endothelin Source: Ensembl
    16. regulation of vasoconstriction Source: InterPro
    17. vein smooth muscle contraction Source: Ensembl

    Keywords - Molecular functioni

    Vasoactive, Vasoconstrictor

    Enzyme and pathway databases

    ReactomeiREACT_204540. Peptide ligand-binding receptors.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endothelin-3
    Short name:
    ET-3
    Alternative name(s):
    Preproendothelin-3
    Short name:
    PPET3
    Gene namesi
    Name:EDN3
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Chromosome 17

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Propeptidei18 – 8063PRO_0000296393Add
    BLAST
    Peptidei83 – 10321Endothelin-3PRO_0000296394Add
    BLAST
    Propeptidei104 – 204101PRO_0000296395Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi83 ↔ 97By similarity
    Disulfide bondi85 ↔ 93By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Interactioni

    Protein-protein interaction databases

    STRINGi9823.ENSSSCP00000008036.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni144 – 15815Endothelin-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the endothelin/sarafotoxin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG41573.
    GeneTreeiENSGT00530000063310.
    HOGENOMiHOG000231110.
    HOVERGENiHBG051442.
    KOiK05227.
    OMAiHHRSRRC.
    OrthoDBiEOG7PCJHP.
    TreeFamiTF333184.

    Family and domain databases

    InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
    IPR019764. Endothelin_toxin_CS.
    IPR001928. Endothln-like_toxin.
    [Graphical view]
    PfamiPF00322. Endothelin. 1 hit.
    [Graphical view]
    PRINTSiPR00365. ENDOTHELIN.
    SMARTiSM00272. END. 2 hits.
    [Graphical view]
    PROSITEiPS00270. ENDOTHELIN. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A5A752-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELRLWFLFG LTVTSAAGPV PRPQPGDAGR SGVPRAPSAT KETMAMVATR    50
    GPSPRSSGQE QEPGPFGELA AKGGPVRYRA RRCTCFTYKD KECVYYCHLD 100
    IIWINTPERT VPYGLSNHRG SVRGRRSAGP SPQSSQPSRG TLRCACAESQ 150
    DRACVYFCTR TLAARGASRT PETPDKEAGK PAGRATGGLH PRRLKSRTDK 200
    ARRL 204
    Length:204
    Mass (Da):22,190
    Last modified:June 12, 2007 - v1
    Checksum:iB66A33C4E19C7662
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB271922 mRNA. Translation: BAF62297.1.
    CR956624 Genomic DNA. Translation: CAN13224.1.
    RefSeqiNP_001092052.1. NM_001098582.2.
    UniGeneiSsc.31972.

    Genome annotation databases

    EnsembliENSSSCT00000008255; ENSSSCP00000008036; ENSSSCG00000007527.
    GeneIDi100049663.
    KEGGissc:100049663.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB271922 mRNA. Translation: BAF62297.1 .
    CR956624 Genomic DNA. Translation: CAN13224.1 .
    RefSeqi NP_001092052.1. NM_001098582.2.
    UniGenei Ssc.31972.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9823.ENSSSCP00000008036.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSSSCT00000008255 ; ENSSSCP00000008036 ; ENSSSCG00000007527 .
    GeneIDi 100049663.
    KEGGi ssc:100049663.

    Organism-specific databases

    CTDi 1908.

    Phylogenomic databases

    eggNOGi NOG41573.
    GeneTreei ENSGT00530000063310.
    HOGENOMi HOG000231110.
    HOVERGENi HBG051442.
    KOi K05227.
    OMAi HHRSRRC.
    OrthoDBi EOG7PCJHP.
    TreeFami TF333184.

    Enzyme and pathway databases

    Reactomei REACT_204540. Peptide ligand-binding receptors.

    Family and domain databases

    InterProi IPR020475. Bibrotoxin/Sarafotoxin-D.
    IPR019764. Endothelin_toxin_CS.
    IPR001928. Endothln-like_toxin.
    [Graphical view ]
    Pfami PF00322. Endothelin. 1 hit.
    [Graphical view ]
    PRINTSi PR00365. ENDOTHELIN.
    SMARTi SM00272. END. 2 hits.
    [Graphical view ]
    PROSITEi PS00270. ENDOTHELIN. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequences and genetic variations of forty-four porcine coat color related genes."
      Okumura N., Matsumoto T., Hamasima N., Uenishi H., Ogawa T., Komatsuda A., Fukudome N., Ide H., Suzuki A., Kojima C., Awata T.
      Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Porcine genome sequencing project
      Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiEDN3_PIG
    AccessioniPrimary (citable) accession number: A5A752
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3