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A5A752 (EDN3_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endothelin-3

Short name=ET-3
Alternative name(s):
Preproendothelin-3
Short name=PPET3
Gene names
Name:EDN3
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length204 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Endothelins are endothelium-derived vasoconstrictor peptides By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the endothelin/sarafotoxin family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionVasoactive
Vasoconstrictor
   PTMCleavage on pair of basic residues
Disulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell surface receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

inositol phosphate-mediated signaling

Inferred from electronic annotation. Source: Ensembl

melanocyte differentiation

Inferred from electronic annotation. Source: Ensembl

neural crest cell migration

Inferred from electronic annotation. Source: Ensembl

neuron differentiation

Inferred from electronic annotation. Source: Ensembl

neutrophil chemotaxis

Inferred from electronic annotation. Source: Ensembl

peptide hormone secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of MAP kinase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of heart rate

Inferred from electronic annotation. Source: Ensembl

positive regulation of hormone secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of leukocyte chemotaxis

Inferred from electronic annotation. Source: Ensembl

positive regulation of mitosis

Inferred from electronic annotation. Source: Ensembl

regulation of developmental pigmentation

Inferred from electronic annotation. Source: Ensembl

regulation of systemic arterial blood pressure by endothelin

Inferred from electronic annotation. Source: Ensembl

regulation of vasoconstriction

Inferred from electronic annotation. Source: InterPro

vein smooth muscle contraction

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Propeptide18 – 8063
PRO_0000296393
Peptide83 – 10321Endothelin-3
PRO_0000296394
Propeptide104 – 204101
PRO_0000296395

Regions

Region144 – 15815Endothelin-like

Sites

Site103 – 1042Cleavage; by KEL By similarity

Amino acid modifications

Disulfide bond83 ↔ 97 By similarity
Disulfide bond85 ↔ 93 By similarity

Sequences

Sequence LengthMass (Da)Tools
A5A752 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: B66A33C4E19C7662

FASTA20422,190
        10         20         30         40         50         60 
MELRLWFLFG LTVTSAAGPV PRPQPGDAGR SGVPRAPSAT KETMAMVATR GPSPRSSGQE 

        70         80         90        100        110        120 
QEPGPFGELA AKGGPVRYRA RRCTCFTYKD KECVYYCHLD IIWINTPERT VPYGLSNHRG 

       130        140        150        160        170        180 
SVRGRRSAGP SPQSSQPSRG TLRCACAESQ DRACVYFCTR TLAARGASRT PETPDKEAGK 

       190        200 
PAGRATGGLH PRRLKSRTDK ARRL 

« Hide

References

« Hide 'large scale' references
[1]"Sequences and genetic variations of forty-four porcine coat color related genes."
Okumura N., Matsumoto T., Hamasima N., Uenishi H., Ogawa T., Komatsuda A., Fukudome N., Ide H., Suzuki A., Kojima C., Awata T.
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Porcine genome sequencing project
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB271922 mRNA. Translation: BAF62297.1.
CR956624 Genomic DNA. Translation: CAN13224.1.
RefSeqNP_001092052.1. NM_001098582.2.
UniGeneSsc.31972.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9823.ENSSSCP00000008036.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSSSCT00000008255; ENSSSCP00000008036; ENSSSCG00000007527.
GeneID100049663.
KEGGssc:100049663.

Organism-specific databases

CTD1908.

Phylogenomic databases

eggNOGNOG41573.
GeneTreeENSGT00530000063310.
HOGENOMHOG000231110.
HOVERGENHBG051442.
KOK05227.
OMAHHRSRRC.
OrthoDBEOG7PCJHP.
TreeFamTF333184.

Family and domain databases

InterProIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSPR00365. ENDOTHELIN.
SMARTSM00272. END. 2 hits.
[Graphical view]
PROSITEPS00270. ENDOTHELIN. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameEDN3_PIG
AccessionPrimary (citable) accession number: A5A752
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: June 12, 2007
Last modified: February 19, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families