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A5A752

- EDN3_PIG

UniProt

A5A752 - EDN3_PIG

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Protein

Endothelin-3

Gene
EDN3
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Endothelins are endothelium-derived vasoconstrictor peptides By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei103 – 1042Cleavage; by KEL By similarity

GO - Biological processi

  1. cell surface receptor signaling pathway Source: Ensembl
  2. inositol phosphate-mediated signaling Source: Ensembl
  3. melanocyte differentiation Source: Ensembl
  4. neural crest cell migration Source: Ensembl
  5. neuron differentiation Source: Ensembl
  6. neutrophil chemotaxis Source: Ensembl
  7. peptide hormone secretion Source: Ensembl
  8. positive regulation of cell proliferation Source: Ensembl
  9. positive regulation of heart rate Source: Ensembl
  10. positive regulation of hormone secretion Source: Ensembl
  11. positive regulation of leukocyte chemotaxis Source: Ensembl
  12. positive regulation of MAP kinase activity Source: Ensembl
  13. positive regulation of mitosis Source: Ensembl
  14. regulation of developmental pigmentation Source: Ensembl
  15. regulation of systemic arterial blood pressure by endothelin Source: Ensembl
  16. regulation of vasoconstriction Source: InterPro
  17. vein smooth muscle contraction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Vasoactive, Vasoconstrictor

Enzyme and pathway databases

ReactomeiREACT_204540. Peptide ligand-binding receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-3
Short name:
ET-3
Alternative name(s):
Preproendothelin-3
Short name:
PPET3
Gene namesi
Name:EDN3
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Chromosome 17

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed predictionAdd
BLAST
Propeptidei18 – 8063PRO_0000296393Add
BLAST
Peptidei83 – 10321Endothelin-3PRO_0000296394Add
BLAST
Propeptidei104 – 204101PRO_0000296395Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi83 ↔ 97 By similarity
Disulfide bondi85 ↔ 93 By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000008036.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni144 – 15815Endothelin-likeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG41573.
GeneTreeiENSGT00530000063310.
HOGENOMiHOG000231110.
HOVERGENiHBG051442.
KOiK05227.
OMAiHHRSRRC.
OrthoDBiEOG7PCJHP.
TreeFamiTF333184.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A5A752-1 [UniParc]FASTAAdd to Basket

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MELRLWFLFG LTVTSAAGPV PRPQPGDAGR SGVPRAPSAT KETMAMVATR    50
GPSPRSSGQE QEPGPFGELA AKGGPVRYRA RRCTCFTYKD KECVYYCHLD 100
IIWINTPERT VPYGLSNHRG SVRGRRSAGP SPQSSQPSRG TLRCACAESQ 150
DRACVYFCTR TLAARGASRT PETPDKEAGK PAGRATGGLH PRRLKSRTDK 200
ARRL 204
Length:204
Mass (Da):22,190
Last modified:June 12, 2007 - v1
Checksum:iB66A33C4E19C7662
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB271922 mRNA. Translation: BAF62297.1.
CR956624 Genomic DNA. Translation: CAN13224.1.
RefSeqiNP_001092052.1. NM_001098582.2.
UniGeneiSsc.31972.

Genome annotation databases

EnsembliENSSSCT00000008255; ENSSSCP00000008036; ENSSSCG00000007527.
GeneIDi100049663.
KEGGissc:100049663.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB271922 mRNA. Translation: BAF62297.1 .
CR956624 Genomic DNA. Translation: CAN13224.1 .
RefSeqi NP_001092052.1. NM_001098582.2.
UniGenei Ssc.31972.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000008036.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSSSCT00000008255 ; ENSSSCP00000008036 ; ENSSSCG00000007527 .
GeneIDi 100049663.
KEGGi ssc:100049663.

Organism-specific databases

CTDi 1908.

Phylogenomic databases

eggNOGi NOG41573.
GeneTreei ENSGT00530000063310.
HOGENOMi HOG000231110.
HOVERGENi HBG051442.
KOi K05227.
OMAi HHRSRRC.
OrthoDBi EOG7PCJHP.
TreeFami TF333184.

Enzyme and pathway databases

Reactomei REACT_204540. Peptide ligand-binding receptors.

Family and domain databases

InterProi IPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view ]
Pfami PF00322. Endothelin. 1 hit.
[Graphical view ]
PRINTSi PR00365. ENDOTHELIN.
SMARTi SM00272. END. 2 hits.
[Graphical view ]
PROSITEi PS00270. ENDOTHELIN. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequences and genetic variations of forty-four porcine coat color related genes."
    Okumura N., Matsumoto T., Hamasima N., Uenishi H., Ogawa T., Komatsuda A., Fukudome N., Ide H., Suzuki A., Kojima C., Awata T.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Porcine genome sequencing project
    Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiEDN3_PIG
AccessioniPrimary (citable) accession number: A5A752
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: June 12, 2007
Last modified: September 3, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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