A5A752 (EDN3_PIG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Endothelin-3
Short name=ET-3

Alternative name(s):
Preproendothelin-3
Short name=PPET3

Gene names

Name:

EDN3

Organism

Sus scrofa (Pig) [Reference proteome]

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	204 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Endothelins are endothelium-derived vasoconstrictor peptides By similarity.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the endothelin/sarafotoxin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Vasoactive Vasoconstrictor
PTM	Cleavage on pair of basic residues Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell surface receptor signaling pathway Inferred from electronic annotation. Source: Compara inositol phosphate-mediated signaling Inferred from electronic annotation. Source: Compara melanocyte differentiation Inferred from electronic annotation. Source: Compara neural crest cell migration Inferred from electronic annotation. Source: Compara neuron differentiation Inferred from electronic annotation. Source: Compara neutrophil chemotaxis Inferred from electronic annotation. Source: Compara peptide hormone secretion Inferred from electronic annotation. Source: Compara positive regulation of MAP kinase activity Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of heart rate Inferred from electronic annotation. Source: Compara positive regulation of hormone secretion Inferred from electronic annotation. Source: Compara positive regulation of leukocyte chemotaxis Inferred from electronic annotation. Source: Compara positive regulation of mitosis Inferred from electronic annotation. Source: Compara regulation of developmental pigmentation Inferred from electronic annotation. Source: Compara regulation of systemic arterial blood pressure by endothelin Inferred from electronic annotation. Source: Compara regulation of vasoconstriction Inferred from electronic annotation. Source: InterPro vein smooth muscle contraction Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular space Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Propeptide	18 – 80	63			PRO_0000296393
	Peptide	83 – 103	21	Endothelin-3		PRO_0000296394
	Propeptide	104 – 204	101			PRO_0000296395
Regions
	Region	144 – 158	15	Endothelin-like
Sites
	Site	103 – 104	2	Cleavage; by KEL By similarity
Amino acid modifications
	Disulfide bond	83 ↔ 97		By similarity
	Disulfide bond	85 ↔ 93		By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5A752 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: B66A33C4E19C7662	FASTA	204	22,190
	10 20 30 40 50 60 MELRLWFLFG LTVTSAAGPV PRPQPGDAGR SGVPRAPSAT KETMAMVATR GPSPRSSGQE 70 80 90 100 110 120 QEPGPFGELA AKGGPVRYRA RRCTCFTYKD KECVYYCHLD IIWINTPERT VPYGLSNHRG 130 140 150 160 170 180 SVRGRRSAGP SPQSSQPSRG TLRCACAESQ DRACVYFCTR TLAARGASRT PETPDKEAGK 190 200 PAGRATGGLH PRRLKSRTDK ARRL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequences and genetic variations of forty-four porcine coat color related genes." Okumura N., Matsumoto T., Hamasima N., Uenishi H., Ogawa T., Komatsuda A., Fukudome N., Ide H., Suzuki A., Kojima C., Awata T. Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Porcine genome sequencing project Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB271922 mRNA. Translation: BAF62297.1. CR956624 Genomic DNA. Translation: CAN13224.1.
RefSeq	NP_001092052.1. NM_001098582.2.
UniGene	Ssc.31972.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	9823.ENSSSCP00000008036.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSSSCT00000008255; ENSSSCP00000008036; ENSSSCG00000007527.
GeneID	100049663.
KEGG	ssc:100049663.
Organism-specific databases
CTD	1908.
Phylogenomic databases
eggNOG	NOG41573.
GeneTree	ENSGT00530000063310.
HOGENOM	HOG000231110.
HOVERGEN	HBG051442.
KO	K05227.
OMA	DCEETVA.
OrthoDB	EOG4Z62PG.
Family and domain databases
InterPro	IPR020475. Bibrotoxin/Sarafotoxin-D. IPR019764. Endothelin_toxin_CS. IPR001928. Endothln-like_toxin. [Graphical view]
Pfam	PF00322. Endothelin. 1 hit. [Graphical view]
PRINTS	PR00365. ENDOTHELIN.
SMART	SM00272. END. 2 hits. [Graphical view]
PROSITE	PS00270. ENDOTHELIN. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EDN3_PIG

Accession

Primary (citable) accession number: A5A752

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	June 12, 2007
Last modified:	April 3, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program