A5A6P2 (ASAH1_PANTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acid ceramidase
Short name=AC
Short name=ACDase
Short name=Acid CDase
EC=3.5.1.23

Alternative name(s):
Acylsphingosine deacylase
N-acylsphingosine amidohydrolase

Gene names

Name:

ASAH1

Organism

Pan troglodytes (Chimpanzee)

Taxonomic identifier

9598 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan

Protein attributes

Sequence length	395 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid By similarity.
Catalytic activity	N-acylsphingosine + H2O = a carboxylate + sphingosine.
Subunit structure	Heterodimer of one alpha and one beta subunit By similarity.
Subcellular location	Lysosome By similarity.
Sequence similarities	Belongs to the acid ceramidase family.

Ontologies

Keywords
Cellular component	Lysosome
Domain	Signal
Molecular function	Hydrolase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	lipid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ceramidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 395	374	Acid ceramidase		PRO_0000378101
Amino acid modifications
	Glycosylation	195	1	N-linked (GlcNAc...) Potential
	Glycosylation	259	1	N-linked (GlcNAc...) Potential
	Glycosylation	286	1	N-linked (GlcNAc...) Potential
	Glycosylation	342	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	A5A6P2 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: 95F276721883EF4B	FASTA	395	44,697
	10 20 30 40 50 60 MPGRSRVALV LLAAAVSCAV AQHAPPWTED CRKSTYPPSG PTYRGPVPWY TINLDLPPYK 70 80 90 100 110 120 RWHELMLDKA PMLKVIVNSL KNMINTFVPS GKIVQVVDEK LPGLLGNFPG PFEEEMKGIA 130 140 150 160 170 180 AVTDIPLGEI ISFNIFYELF TICTSIVAED KKGHLIHGRN MDFGVFLGWN INNDTWVITE 190 200 210 220 230 240 QLKPLTVNLD FQRNNKTVFK ASSFAGYVGM LTGFKPGLFS LSLNERFSIN GGYLGILEWI 250 260 270 280 290 300 LGKKDAMWIG FLTRTVLENS TSYEEAKNLL TKTKILAPAY FILGGNQSGE GCVITRDRKE 310 320 330 340 350 360 SLDVYELDAK QGRWYVVQTN YDRWKHPFFL DDRRTPAKMC LNRTSQENIS FETMYDVLST 370 380 390 KPVLNKLTVY TTLIDVTKGQ FETYLRDCPD PCIGW

References

[1]

"Mapping of chimpanzee full-length cDNAs onto the human genome unveils large potential divergence of the transcriptome." Sakate R., Suto Y., Imanishi T., Tanoue T., Hida M., Hayasaka I., Kusuda J., Gojobori T., Hashimoto K., Hirai M. Gene 399:1-10(2007) [PubMed: 17574350] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Subsp. verus. Tissue: Skin.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB222170 mRNA. Translation: BAF62415.1.
RefSeq	NP_001092030.1. NM_001098560.1.
UniGene	Ptr.2655.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A5A6P2.
Protein family/group databases
MEROPS	C89.001.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSPTRT00000037110; ENSPTRP00000034295; ENSPTRG00000020027.
GeneID	464022.
KEGG	ptr:464022.
Organism-specific databases
CTD	427.
Family and domain databases
InterPro	IPR016699. Acid_ceramidase-like. IPR003199. Chologlycine_hydro. [Graphical view]
KO	K12348.
Pfam	PF02275. CBAH. 1 hit. [Graphical view]
PIRSF	PIRSF017632. Acid_ceramidase-like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ASAH1_PANTR

Accession

Primary (citable) accession number: A5A6P2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 16, 2009
Last sequence update:	June 12, 2007
Last modified:	November 16, 2011
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program