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Protein

Keratin, type II cytoskeletal 7

Gene

KRT7

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Blocks interferon-dependent interphase and stimulates DNA synthesis in cells.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei343 – 3431StutterSequence analysis

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 7
Alternative name(s):
Cytokeratin-7
Short name:
CK-7
Keratin-7
Short name:
K7
Type-II keratin Kb7
Gene namesi
Name:KRT7Imported
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 469468Keratin, type II cytoskeletal 7PRO_0000307636Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei2 – 21PhosphoserineBy similarity
Modified residuei20 – 201Dimethylated arginine; alternateBy similarity
Modified residuei20 – 201Omega-N-methylarginine; alternateBy similarity
Cross-linki130 – 130Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei179 – 1791N6-acetyllysineBy similarity
Modified residuei252 – 2521PhosphoserineBy similarity
Modified residuei254 – 2541PhosphoserineBy similarity

Post-translational modificationi

Arg-20 is dimethylated, probably to asymmetric dimethylarginine.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiA5A6N0.
PRIDEiA5A6N0.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Interacts with eukaryotic translation initiator factor 3 (eIF3) subunit EIF3S10. Interacts with GPER1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000008481.

Structurei

3D structure databases

ProteinModelPortaliA5A6N0.
SMRiA5A6N0. Positions 90-126.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 9089HeadSequence analysisAdd
BLAST
Regioni90 – 12637Coil 1ASequence analysisAdd
BLAST
Regioni91 – 399309RodSequence analysisAdd
BLAST
Regioni127 – 14418Linker 1Sequence analysisAdd
BLAST
Regioni145 – 23692Coil 1BSequence analysisAdd
BLAST
Regioni237 – 26024Linker 12Sequence analysisAdd
BLAST
Regioni261 – 399139Coil 2Sequence analysisAdd
BLAST
Regioni400 – 46970TailSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG4R. Eukaryota.
ENOG410YY6B. LUCA.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiA5A6N0.
KOiK07605.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A5A6N0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIHFSSPVF TSRSAAFSGR GAQVRLSSAR PGGLGSSSLY GLGASRPRVA
60 70 80 90 100
VRSAYGGPVG AGIREVTINQ SLLAPLRLDA DPSLQRVRQE EREQIKTLNN
110 120 130 140 150
KFASFIDKVR FLEQQNKLLE TKWTLLQEQK SAKSSRLPDI FEAQIAGLRG
160 170 180 190 200
QLEALQVDGG RLEAELQSMQ DVVEDFKNKY EDEINRRAAA ENEFVVLKKD
210 220 230 240 250
VDAAYMSKVE LEAKVDALND EINFLRTLNE TELTELQSQI SDTSVVLSMD
260 270 280 290 300
NSRSLDLDGI IAEVKAQYEE MAKCSRAEAE AWYQTKFETL QAQAGKHGDD
310 320 330 340 350
LRNTRNEISE MNRAIQRLQA EIDNIKDQRA KLEAAIAEAE ERGELALKDA
360 370 380 390 400
RAKQEELEAA LQRAKQDMAR QLREYQELMS VKLALDIEIA TYRKLLEGEE
410 420 430 440 450
SRLAGDGVGA VNISVMNSTG GSSSGGGIGL TLGGTMGSNA LSFSSSAGPG
460
PLKAYSIRTA SASRRSARN
Length:469
Mass (Da):51,414
Last modified:June 12, 2007 - v1
Checksum:i66DD245C9DA2DBD9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB222158 mRNA. Translation: BAF62403.1.
RefSeqiNP_001104284.1. NM_001110814.1.
UniGeneiPtr.6275.

Genome annotation databases

GeneIDi466983.
KEGGiptr:466983.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB222158 mRNA. Translation: BAF62403.1.
RefSeqiNP_001104284.1. NM_001110814.1.
UniGeneiPtr.6275.

3D structure databases

ProteinModelPortaliA5A6N0.
SMRiA5A6N0. Positions 90-126.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000008481.

Proteomic databases

PaxDbiA5A6N0.
PRIDEiA5A6N0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi466983.
KEGGiptr:466983.

Organism-specific databases

CTDi3855.

Phylogenomic databases

eggNOGiENOG410IG4R. Eukaryota.
ENOG410YY6B. LUCA.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiA5A6N0.
KOiK07605.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Mapping of chimpanzee full-length cDNAs onto the human genome unveils large potential divergence of the transcriptome."
    Sakate R., Suto Y., Imanishi T., Tanoue T., Hida M., Hayasaka I., Kusuda J., Gojobori T., Hashimoto K., Hirai M.
    Gene 399:1-10(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: SkinImported.

Entry informationi

Entry nameiK2C7_PANTR
AccessioniPrimary (citable) accession number: A5A6N0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: June 12, 2007
Last modified: June 8, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.