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Protein

Keratin, type II cytoskeletal 5

Gene

KRT5

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei421Stutter1

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 5
Alternative name(s):
Cytokeratin-5
Short name:
CK-5
Keratin-5
Short name:
K5
Type-II keratin Kb5
Gene namesi
Name:KRT5
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003568261 – 592Keratin, type II cytoskeletal 5Add BLAST592

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5PhosphoserineBy similarity1
Modified residuei8PhosphoserineBy similarity1
Modified residuei16PhosphoserineBy similarity1
Modified residuei21PhosphoserineBy similarity1
Modified residuei26PhosphoserineBy similarity1
Modified residuei36PhosphoserineBy similarity1
Modified residuei50PhosphoserineBy similarity1
Modified residuei64PhosphoserineBy similarity1
Modified residuei71PhosphoserineBy similarity1
Modified residuei75PhosphoserineBy similarity1
Modified residuei82PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiA5A6M8.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Keratin-5 associates with keratin-14. Interacts with TCHP (By similarity). Interacts with KEPPK1 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliA5A6M8.
SMRiA5A6M8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 169HeadAdd BLAST169
Regioni170 – 479RodAdd BLAST310
Regioni170 – 205Coil 1AAdd BLAST36
Regioni206 – 224Linker 1Add BLAST19
Regioni225 – 317Coil 1BAdd BLAST93
Regioni318 – 340Linker 12Add BLAST23
Regioni341 – 479Coil 2Add BLAST139
Regioni480 – 592TailAdd BLAST113

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi39 – 141Gly-richAdd BLAST103
Compositional biasi530 – 592Ser-richAdd BLAST63

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiA5A6M8.
KOiK07605.

Family and domain databases

InterProiView protein in InterPro
IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiView protein in Pfam
PF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
PRINTSiPR01276. TYPE2KERATIN.
SMARTiView protein in SMART
SM01391. Filament. 1 hit.
PROSITEiView protein in PROSITE
PS00226. IF. 1 hit.

Sequencei

Sequence statusi: Complete.

A5A6M8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRQSSVSFR SGGSRSFSTA SAITPSVSRT SFTSVSRSGG GGGGGFGRVS
60 70 80 90 100
LGGACGVGGY GSRSLYNLGG SKWISISTSG GSFRNRFGAG AGAGGGYGFG
110 120 130 140 150
GGAGSGFGFG GGAGGGFGLG GGAGFGGGYG GPGFPVCPPG GIQEVTVNQS
160 170 180 190 200
LLTPLNLQID PSIQRVRTEE REQIKTLNNK FASFIDKVRF LEQQNKVLDT
210 220 230 240 250
KWTLLQEQGT KTVRQNLEPL FEQYINNLRR QLDSIVGERG RLDSELRNMQ
260 270 280 290 300
DLVEDFKNKY EDEINKRTTA ENEFVMLKKD VDAAYMNKVE LEAKVDALMD
310 320 330 340 350
EINFMKMFFD AELSQMQTHV SDTSVVLSMD NNRNLDLDSI IAEVKAQYEE
360 370 380 390 400
IANRSRTEAE SWYQTKYEEL QQTAGRHGDD LRNTKHEISE MNRMIQRLRA
410 420 430 440 450
EIDNVKKQCA NLQNAIADAE QRGELALKDA RNKLAELEEA LQKAKQDMAR
460 470 480 490 500
LLREYQELMN TKLALDVEIA TYRKLLEGEE CRLSGEGVGP VNISVVTSSV
510 520 530 540 550
SSGYGSGSGY GGGLGGGLGG GLGGSLAGGG SGSYYSSSSG GVGLGGGLSV
560 570 580 590
GGSGFSASSG RGLGVGFGSG GGSSSSVKFV STTSSSRKSF KS
Length:592
Mass (Da):62,538
Last modified:June 12, 2007 - v1
Checksum:i4EC68886890D89BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB222156 mRNA. Translation: BAF62401.1.
RefSeqiNP_001266996.1. NM_001280067.1.
UniGeneiPtr.2691.

Genome annotation databases

GeneIDi100615215.
KEGGiptr:100615215.

Similar proteinsi

Entry informationi

Entry nameiK2C5_PANTR
AccessioniPrimary (citable) accession number: A5A6M8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: June 12, 2007
Last modified: August 30, 2017
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families