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A5A6L1 (CYR61_PANTR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein CYR61
Alternative name(s):
Cysteine-rich angiogenic inducer 61
Gene names
Name:CYR61
OrganismPan troglodytes (Chimpanzee) [Reference proteome]
Taxonomic identifier9598 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan

Protein attributes

Sequence length381 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 By similarity. CYR61-mediated gene regulation is dependent on heparin-binding By similarity. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 By similarity. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-1/beta-5 and cell proliferation through integrin alpha-v/beta-3 By similarity.

Subunit structure

Interaction with integrins is heparin- and cell-type-dependent and promotes cell adhesion By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the CCN family.

Contains 1 CTCK (C-terminal cystine knot-like) domain.

Contains 1 IGFBP N-terminal domain.

Contains 1 TSP type-1 domain.

Contains 1 VWFC domain.

Ontologies

Keywords
   Biological processCell adhesion
Chemotaxis
   Cellular componentSecreted
   DomainSignal
   LigandGrowth factor binding
Heparin-binding
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic process involved in heart morphogenesis

Inferred from electronic annotation. Source: Ensembl

atrial septum morphogenesis

Inferred from electronic annotation. Source: Ensembl

atrioventricular valve morphogenesis

Inferred from electronic annotation. Source: Ensembl

chemotaxis

Inferred from electronic annotation. Source: UniProtKB-KW

chondroblast differentiation

Inferred from electronic annotation. Source: Ensembl

chorio-allantoic fusion

Inferred from electronic annotation. Source: Ensembl

extracellular matrix organization

Inferred from electronic annotation. Source: Ensembl

intussusceptive angiogenesis

Inferred from electronic annotation. Source: Ensembl

labyrinthine layer blood vessel development

Inferred from electronic annotation. Source: Ensembl

negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

osteoblast differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of BMP signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of cartilage development

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell migration

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell-substrate adhesion

Inferred from electronic annotation. Source: Ensembl

positive regulation of ceramide biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of osteoblast differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of osteoblast proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of phospholipase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein kinase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

reactive oxygen species metabolic process

Inferred from electronic annotation. Source: Ensembl

regulation of ERK1 and ERK2 cascade

Inferred from electronic annotation. Source: Ensembl

regulation of cell growth

Inferred from electronic annotation. Source: InterPro

ventricular septum development

Inferred from electronic annotation. Source: Ensembl

wound healing, spreading of cells

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionextracellular matrix binding

Inferred from electronic annotation. Source: Ensembl

heparin binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 381357Protein CYR61
PRO_0000297553

Regions

Domain25 – 9470IGFBP N-terminal
Domain98 – 16467VWFC
Domain228 – 27346TSP type-1
Domain286 – 36075CTCK
Region279 – 31537Heparin-binding By similarity

Amino acid modifications

Disulfide bond286 ↔ 323 By similarity
Disulfide bond303 ↔ 337 By similarity
Disulfide bond314 ↔ 353 By similarity
Disulfide bond317 ↔ 355 By similarity
Disulfide bond322 ↔ 359 By similarity

Sequences

Sequence LengthMass (Da)Tools
A5A6L1 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 923330133F2A7F8B

FASTA38142,013
        10         20         30         40         50         60 
MSSRIARALA LVVTLLHLTR LALSTCPAAC HCPLEAPKCA PGVGLVRDGC GCCKVCAKQL 

        70         80         90        100        110        120 
NEDCSKTQPC DHTKGLECNF GASSTALKGI CRAQSEGRPC EYNSRIYQNG ESFQPNCKHQ 

       130        140        150        160        170        180 
CTCIDGAVGC IPLCPQELSL PNLGCPNPRL VKVSGQCCEE WVCDEDSIKD PMEDQDGLLG 

       190        200        210        220        230        240 
KELGFDASEV ELTRNNELIA VGKGSSLKRL PVFGMEPRIL YNPLQGQKCI VQTTSWSQCS 

       250        260        270        280        290        300 
KTCGTGISTR VTNDNPECRL VKETRICEVR PCGQPVYSSL KKGKKCSKTK KSPEPVRFTY 

       310        320        330        340        350        360 
AGCLSVKKYR PKYCGSCVDG RCCTPQLTRT VKMRFRCEDG ETFSKNVMMI QSCKCNYNCP 

       370        380 
HANEAAFPFY RLFNDIHKFR D 

« Hide

References

[1]"Mapping of chimpanzee full-length cDNAs onto the human genome unveils large potential divergence of the transcriptome."
Sakate R., Suto Y., Imanishi T., Tanoue T., Hida M., Hayasaka I., Kusuda J., Gojobori T., Hashimoto K., Hirai M.
Gene 399:1-10(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB222139 mRNA. Translation: BAF62384.1.
RefSeqNP_001092023.1. NM_001098553.1.
UniGenePtr.5551.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9598.ENSPTRP00000001581.

Proteomic databases

PRIDEA5A6L1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSPTRT00000001732; ENSPTRP00000001581; ENSPTRG00000000916.
GeneID456988.
KEGGptr:456988.

Organism-specific databases

CTD3491.

Phylogenomic databases

eggNOGNOG82014.
HOGENOMHOG000231462.
HOVERGENHBG000635.
InParanoidA5A6L1.
KOK06829.
OMAKCIVQTT.
OrthoDBEOG7N8ZXB.
TreeFamTF326070.

Family and domain databases

InterProIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamPF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PIRSFPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTSM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20837894.

Entry information

Entry nameCYR61_PANTR
AccessionPrimary (citable) accession number: A5A6L1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: June 12, 2007
Last modified: April 16, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families