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A5A6L1

- CYR61_PANTR

UniProt

A5A6L1 - CYR61_PANTR

Protein

Protein CYR61

Gene

CYR61

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 By similarity. CYR61-mediated gene regulation is dependent on heparin-binding By similarity. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 By similarity. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-1/beta-5 and cell proliferation through integrin alpha-v/beta-3 By similarity.By similarity

    GO - Molecular functioni

    1. extracellular matrix binding Source: Ensembl
    2. heparin binding Source: UniProtKB-KW

    GO - Biological processi

    1. apoptotic process involved in heart morphogenesis Source: Ensembl
    2. atrial septum morphogenesis Source: Ensembl
    3. atrioventricular valve morphogenesis Source: Ensembl
    4. chemotaxis Source: UniProtKB-KW
    5. chondroblast differentiation Source: Ensembl
    6. chorio-allantoic fusion Source: Ensembl
    7. extracellular matrix organization Source: Ensembl
    8. intussusceptive angiogenesis Source: Ensembl
    9. labyrinthine layer blood vessel development Source: Ensembl
    10. negative regulation of apoptotic process Source: Ensembl
    11. osteoblast differentiation Source: Ensembl
    12. positive regulation of apoptotic process Source: Ensembl
    13. positive regulation of BMP signaling pathway Source: Ensembl
    14. positive regulation of cartilage development Source: Ensembl
    15. positive regulation of cell migration Source: Ensembl
    16. positive regulation of cell-substrate adhesion Source: Ensembl
    17. positive regulation of ceramide biosynthetic process Source: Ensembl
    18. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    19. positive regulation of osteoblast differentiation Source: Ensembl
    20. positive regulation of osteoblast proliferation Source: Ensembl
    21. positive regulation of phospholipase activity Source: Ensembl
    22. positive regulation of protein kinase activity Source: Ensembl
    23. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    24. reactive oxygen species metabolic process Source: Ensembl
    25. regulation of cell growth Source: InterPro
    26. regulation of ERK1 and ERK2 cascade Source: Ensembl
    27. ventricular septum development Source: Ensembl
    28. wound healing, spreading of cells Source: Ensembl

    Keywords - Biological processi

    Cell adhesion, Chemotaxis

    Keywords - Ligandi

    Growth factor binding, Heparin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein CYR61
    Alternative name(s):
    Cysteine-rich angiogenic inducer 61
    Gene namesi
    Name:CYR61
    OrganismiPan troglodytes (Chimpanzee)
    Taxonomic identifieri9598 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
    ProteomesiUP000002277: Chromosome 1

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 381357Protein CYR61PRO_0000297553Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi286 ↔ 323By similarity
    Disulfide bondi303 ↔ 337By similarity
    Disulfide bondi314 ↔ 353By similarity
    Disulfide bondi317 ↔ 355By similarity
    Disulfide bondi322 ↔ 359By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiA5A6L1.

    Interactioni

    Subunit structurei

    Interaction with integrins is heparin- and cell-type-dependent and promotes cell adhesion.By similarity

    Protein-protein interaction databases

    STRINGi9598.ENSPTRP00000001581.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 9470IGFBP N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini98 – 16467VWFCPROSITE-ProRule annotationAdd
    BLAST
    Domaini228 – 27346TSP type-1PROSITE-ProRule annotationAdd
    BLAST
    Domaini286 – 36075CTCKPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni279 – 31537Heparin-bindingBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CCN family.Curated
    Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
    Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
    Contains 1 TSP type-1 domain.PROSITE-ProRule annotation
    Contains 1 VWFC domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG82014.
    HOGENOMiHOG000231462.
    HOVERGENiHBG000635.
    InParanoidiA5A6L1.
    KOiK06829.
    OMAiKCIVQTT.
    OrthoDBiEOG7N8ZXB.
    TreeFamiTF326070.

    Family and domain databases

    InterProiIPR006207. Cys_knot_C.
    IPR006208. Glyco_hormone_CN.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR000867. IGFBP-like.
    IPR012395. IGFBP_CNN.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000884. Thrombospondin_1_rpt.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF00007. Cys_knot. 1 hit.
    PF00219. IGFBP. 1 hit.
    PF00090. TSP_1. 1 hit.
    PF00093. VWC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
    SMARTiSM00041. CT. 1 hit.
    SM00121. IB. 1 hit.
    SM00209. TSP1. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    SSF82895. SSF82895. 1 hit.
    PROSITEiPS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS50092. TSP1. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A5A6L1-1 [UniParc]FASTAAdd to Basket

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    MSSRIARALA LVVTLLHLTR LALSTCPAAC HCPLEAPKCA PGVGLVRDGC    50
    GCCKVCAKQL NEDCSKTQPC DHTKGLECNF GASSTALKGI CRAQSEGRPC 100
    EYNSRIYQNG ESFQPNCKHQ CTCIDGAVGC IPLCPQELSL PNLGCPNPRL 150
    VKVSGQCCEE WVCDEDSIKD PMEDQDGLLG KELGFDASEV ELTRNNELIA 200
    VGKGSSLKRL PVFGMEPRIL YNPLQGQKCI VQTTSWSQCS KTCGTGISTR 250
    VTNDNPECRL VKETRICEVR PCGQPVYSSL KKGKKCSKTK KSPEPVRFTY 300
    AGCLSVKKYR PKYCGSCVDG RCCTPQLTRT VKMRFRCEDG ETFSKNVMMI 350
    QSCKCNYNCP HANEAAFPFY RLFNDIHKFR D 381
    Length:381
    Mass (Da):42,013
    Last modified:June 12, 2007 - v1
    Checksum:i923330133F2A7F8B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB222139 mRNA. Translation: BAF62384.1.
    RefSeqiNP_001092023.1. NM_001098553.1.
    UniGeneiPtr.5551.

    Genome annotation databases

    EnsembliENSPTRT00000001732; ENSPTRP00000001581; ENSPTRG00000000916.
    GeneIDi456988.
    KEGGiptr:456988.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB222139 mRNA. Translation: BAF62384.1 .
    RefSeqi NP_001092023.1. NM_001098553.1.
    UniGenei Ptr.5551.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9598.ENSPTRP00000001581.

    Proteomic databases

    PRIDEi A5A6L1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSPTRT00000001732 ; ENSPTRP00000001581 ; ENSPTRG00000000916 .
    GeneIDi 456988.
    KEGGi ptr:456988.

    Organism-specific databases

    CTDi 3491.

    Phylogenomic databases

    eggNOGi NOG82014.
    HOGENOMi HOG000231462.
    HOVERGENi HBG000635.
    InParanoidi A5A6L1.
    KOi K06829.
    OMAi KCIVQTT.
    OrthoDBi EOG7N8ZXB.
    TreeFami TF326070.

    Miscellaneous databases

    NextBioi 20837894.

    Family and domain databases

    InterProi IPR006207. Cys_knot_C.
    IPR006208. Glyco_hormone_CN.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR000867. IGFBP-like.
    IPR012395. IGFBP_CNN.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000884. Thrombospondin_1_rpt.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF00007. Cys_knot. 1 hit.
    PF00219. IGFBP. 1 hit.
    PF00090. TSP_1. 1 hit.
    PF00093. VWC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036495. IGFBP_rP_CNN. 1 hit.
    SMARTi SM00041. CT. 1 hit.
    SM00121. IB. 1 hit.
    SM00209. TSP1. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    SSF82895. SSF82895. 1 hit.
    PROSITEi PS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS50092. TSP1. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mapping of chimpanzee full-length cDNAs onto the human genome unveils large potential divergence of the transcriptome."
      Sakate R., Suto Y., Imanishi T., Tanoue T., Hida M., Hayasaka I., Kusuda J., Gojobori T., Hashimoto K., Hirai M.
      Gene 399:1-10(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiCYR61_PANTR
    AccessioniPrimary (citable) accession number: A5A6L1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3