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A5A6L1

- CYR61_PANTR

UniProt

A5A6L1 - CYR61_PANTR

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Protein
Protein CYR61
Gene
CYR61
Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 By similarity. CYR61-mediated gene regulation is dependent on heparin-binding By similarity. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 By similarity. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-1/beta-5 and cell proliferation through integrin alpha-v/beta-3 By similarity.

GO - Molecular functioni

  1. extracellular matrix binding Source: Ensembl
  2. heparin binding Source: UniProtKB-KW

GO - Biological processi

  1. apoptotic process involved in heart morphogenesis Source: Ensembl
  2. atrial septum morphogenesis Source: Ensembl
  3. atrioventricular valve morphogenesis Source: Ensembl
  4. chemotaxis Source: UniProtKB-KW
  5. chondroblast differentiation Source: Ensembl
  6. chorio-allantoic fusion Source: Ensembl
  7. extracellular matrix organization Source: Ensembl
  8. intussusceptive angiogenesis Source: Ensembl
  9. labyrinthine layer blood vessel development Source: Ensembl
  10. negative regulation of apoptotic process Source: Ensembl
  11. osteoblast differentiation Source: Ensembl
  12. positive regulation of BMP signaling pathway Source: Ensembl
  13. positive regulation of apoptotic process Source: Ensembl
  14. positive regulation of cartilage development Source: Ensembl
  15. positive regulation of cell migration Source: Ensembl
  16. positive regulation of cell-substrate adhesion Source: Ensembl
  17. positive regulation of ceramide biosynthetic process Source: Ensembl
  18. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  19. positive regulation of osteoblast differentiation Source: Ensembl
  20. positive regulation of osteoblast proliferation Source: Ensembl
  21. positive regulation of phospholipase activity Source: Ensembl
  22. positive regulation of protein kinase activity Source: Ensembl
  23. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  24. reactive oxygen species metabolic process Source: Ensembl
  25. regulation of ERK1 and ERK2 cascade Source: Ensembl
  26. regulation of cell growth Source: InterPro
  27. ventricular septum development Source: Ensembl
  28. wound healing, spreading of cells Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Chemotaxis

Keywords - Ligandi

Growth factor binding, Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CYR61
Alternative name(s):
Cysteine-rich angiogenic inducer 61
Gene namesi
Name:CYR61
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
ProteomesiUP000002277: Chromosome 1

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed prediction
Add
BLAST
Chaini25 – 381357Protein CYR61
PRO_0000297553Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi286 ↔ 323 By similarity
Disulfide bondi303 ↔ 337 By similarity
Disulfide bondi314 ↔ 353 By similarity
Disulfide bondi317 ↔ 355 By similarity
Disulfide bondi322 ↔ 359 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiA5A6L1.

Interactioni

Subunit structurei

Interaction with integrins is heparin- and cell-type-dependent and promotes cell adhesion By similarity.

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000001581.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 9470IGFBP N-terminal
Add
BLAST
Domaini98 – 16467VWFC
Add
BLAST
Domaini228 – 27346TSP type-1
Add
BLAST
Domaini286 – 36075CTCK
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni279 – 31537Heparin-binding By similarity
Add
BLAST

Sequence similaritiesi

Belongs to the CCN family.
Contains 1 TSP type-1 domain.
Contains 1 VWFC domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG82014.
HOGENOMiHOG000231462.
HOVERGENiHBG000635.
InParanoidiA5A6L1.
KOiK06829.
OMAiKCIVQTT.
OrthoDBiEOG7N8ZXB.
TreeFamiTF326070.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamiPF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTiSM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A5A6L1-1 [UniParc]FASTAAdd to Basket

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MSSRIARALA LVVTLLHLTR LALSTCPAAC HCPLEAPKCA PGVGLVRDGC    50
GCCKVCAKQL NEDCSKTQPC DHTKGLECNF GASSTALKGI CRAQSEGRPC 100
EYNSRIYQNG ESFQPNCKHQ CTCIDGAVGC IPLCPQELSL PNLGCPNPRL 150
VKVSGQCCEE WVCDEDSIKD PMEDQDGLLG KELGFDASEV ELTRNNELIA 200
VGKGSSLKRL PVFGMEPRIL YNPLQGQKCI VQTTSWSQCS KTCGTGISTR 250
VTNDNPECRL VKETRICEVR PCGQPVYSSL KKGKKCSKTK KSPEPVRFTY 300
AGCLSVKKYR PKYCGSCVDG RCCTPQLTRT VKMRFRCEDG ETFSKNVMMI 350
QSCKCNYNCP HANEAAFPFY RLFNDIHKFR D 381
Length:381
Mass (Da):42,013
Last modified:June 12, 2007 - v1
Checksum:i923330133F2A7F8B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB222139 mRNA. Translation: BAF62384.1.
RefSeqiNP_001092023.1. NM_001098553.1.
UniGeneiPtr.5551.

Genome annotation databases

EnsembliENSPTRT00000001732; ENSPTRP00000001581; ENSPTRG00000000916.
GeneIDi456988.
KEGGiptr:456988.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB222139 mRNA. Translation: BAF62384.1 .
RefSeqi NP_001092023.1. NM_001098553.1.
UniGenei Ptr.5551.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9598.ENSPTRP00000001581.

Proteomic databases

PRIDEi A5A6L1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPTRT00000001732 ; ENSPTRP00000001581 ; ENSPTRG00000000916 .
GeneIDi 456988.
KEGGi ptr:456988.

Organism-specific databases

CTDi 3491.

Phylogenomic databases

eggNOGi NOG82014.
HOGENOMi HOG000231462.
HOVERGENi HBG000635.
InParanoidi A5A6L1.
KOi K06829.
OMAi KCIVQTT.
OrthoDBi EOG7N8ZXB.
TreeFami TF326070.

Miscellaneous databases

NextBioi 20837894.

Family and domain databases

InterProi IPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view ]
PIRSFi PIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTi SM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEi PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mapping of chimpanzee full-length cDNAs onto the human genome unveils large potential divergence of the transcriptome."
    Sakate R., Suto Y., Imanishi T., Tanoue T., Hida M., Hayasaka I., Kusuda J., Gojobori T., Hashimoto K., Hirai M.
    Gene 399:1-10(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCYR61_PANTR
AccessioniPrimary (citable) accession number: A5A6L1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: June 12, 2007
Last modified: April 16, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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