Reviewed,
UniProtKB/Swiss-Prot A5A6K3 (MPI_PANTR)
Last modified
October 13, 2009.
Version 19.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Mannose-6-phosphate isomerase EC=5.3.1.8 Alternative name(s): Phosphomannose isomerase Short name=PMI Phosphohexomutase | ||
| Gene names |
| ||
| Organism | Pan troglodytes (Chimpanzee) | ||
| Taxonomic identifier | 9598 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan |
Protein attributes
| Sequence length | 423 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions By similarity. |
| Catalytic activity | D-mannose 6-phosphate = D-fructose 6-phosphate. |
| Cofactor | Binds 1 zinc ion per subunit By similarity. |
| Pathway | |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the mannose-6-phosphate isomerase type 1 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Ligand | Metal-binding Zinc |
| Molecular function | Isomerase |
| Gene Ontology (GO) | |
| Biological process | carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | mannose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed By similarity | ||||||
| Chain | 2 – 423 | 422 | Mannose-6-phosphate isomerase | PRO_0000296675 | |||||
Sites | |||||||||
| Active site | 295 | 1 | By similarity | ||||||
| Metal binding | 110 | 1 | Zinc By similarity | ||||||
| Metal binding | 112 | 1 | Zinc By similarity | ||||||
| Metal binding | 137 | 1 | Zinc By similarity | ||||||
| Metal binding | 276 | 1 | Zinc By similarity | ||||||
Sequences
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References
| [1] | "Mapping of chimpanzee full-length cDNAs onto the human genome unveils large potential divergence of the transcriptome." Sakate R., Suto Y., Imanishi T., Tanoue T., Hida M., Hayasaka I., Kusuda J., Gojobori T., Hashimoto K., Hirai M. Gene 399:1-10(2007) [PubMed: 17574350] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain. |
Cross-references
Sequence databases | |
|---|---|
| AB222131 mRNA. Translation: BAF62376.1. | |
| RefSeq | NP_001092020.1. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | A5A6K3. |
Genome annotation databases | |
| Ensembl | ENSPTRT00000013454; ENSPTRP00000012471; ENSPTRG00000007287; Pan troglodytes. [Genome view] |
| GeneID | 453748. |
| KEGG | ptr:453748. |
Organism-specific databases | |
| CTD | 453748. |
Enzyme and pathway databases | |
| BRENDA | 5.3.1.8. 264977. |
Family and domain databases | |
| InterPro | IPR001250. Man6P_Isoase-1. IPR016305. Mannose-6-P_Isomerase. IPR018050. Pmannose_isomerase-type1_CS. [Graphical view] |
| Pfam | PF01238. PMI_typeI. 1 hit. [Graphical view] |
| PIRSF | PIRSF001480. Mannose-6-phosphate_isomerase. 1 hit. |
| PRINTS | PR00714. MAN6PISMRASE. |
| TIGRFAMs | TIGR00218. manA. 1 hit. |
| PROSITE | PS00965. PMI_I_1. 1 hit. PS00966. PMI_I_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MPI_PANTR | ||||||||
| Accession | Primary (citable) accession number: A5A6K3 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


