Reviewed, UniProtKB/Swiss-Prot A5A6I5 (ALDOA_PANTR)

Names and origin

Protein names

Recommended name:
    Fructose-bisphosphate aldolase A
    EC=4.1.2.13
Alternative name(s):
    Muscle-type aldolase

Gene names

Name:

ALDOA

Organism

Pan troglodytes (Chimpanzee)

Taxonomic identifier

9598 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.
Subunit structure	Homotetramer By similarity.
Miscellaneous	In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.
Sequence similarities	Belongs to the class I fructose-bisphosphate aldolase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	Schiff base
Molecular function	Lyase
PTM	Acetylation Phosphoprotein
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	fructose-bisphosphate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 364	363	Fructose-bisphosphate aldolase A		PRO_0000295307
Sites
	Active site	188	1	Proton acceptor By similarity
	Active site	230	1	Schiff-base intermediate with dihydroxyacetone-P
	Binding site	56	1	Substrate
	Binding site	147	1	Substrate
	Site	364	1	Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate
Amino acid modifications
	Modified residue	3	1	Phosphotyrosine By similarity
	Modified residue	5	1	Phosphotyrosine By similarity
	Modified residue	9	1	Phosphothreonine By similarity
	Modified residue	13	1	N6-acetyllysine By similarity
	Modified residue	36	1	Phosphoserine By similarity
	Modified residue	37	1	Phosphothreonine By similarity
	Modified residue	39	1	Phosphoserine By similarity
	Modified residue	42	1	N6-acetyllysine By similarity
	Modified residue	46	1	Phosphoserine By similarity
	Modified residue	65	1	Phosphothreonine By similarity
	Modified residue	108	1	N6-acetyllysine By similarity
	Modified residue	204	1	Phosphotyrosine By similarity
	Modified residue	223	1	Phosphotyrosine By similarity
	Modified residue	235	1	Phosphothreonine By similarity
	Modified residue	241	1	Phosphothreonine By similarity
	Modified residue	330	1	N6-acetyllysine By similarity
	Modified residue	354	1	Phosphoserine By similarity
	Modified residue	356	1	Phosphoserine By similarity
	Modified residue	364	1	Phosphotyrosine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5A6I5-1 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: B3D6546B86D4E604	FASTA	364	39,434
	10 20 30 40 50 60 MPYQYPALTP EQKKELSDIA HRIVAPGKGI LAADESTGSI AKRLQSIGTE NTEENRRFYR 70 80 90 100 110 120 QLLLTADDRV NPCIVGVILF HETLYQKADD GRPFPQVIKS KGGVVGIKVD KGVVPLAGTN 130 140 150 160 170 180 GETTTQGLDG LSERCAQYKK DGADFAKWRC VLKIGEHTPS ALAIMENANV LARYASICQQ 190 200 210 220 230 240 NGIVPIAEPE ILPDGDHDLK RCQYVTEKVL AAVYKALSDH HIYLEGTLLK PNMVTPGHAC 250 260 270 280 290 300 TQKFSHEEIA MATVTALRRT VPPAVTGITF LSGGQSEEEA SINLNAINKC PLLKPWALTF 310 320 330 340 350 360 SYGRALQASA LKAWGGKKEN LKAAQEEYVK RALANSLACQ GKYTPSGQAG AAASESLFVS NHAY

References

[1]

"Mapping of chimpanzee full-length cDNAs onto the human genome unveils large potential divergence of the transcriptome." Sakate R., Suto Y., Imanishi T., Tanoue T., Hida M., Hayasaka I., Kusuda J., Gojobori T., Hashimoto K., Hirai M. Gene 399:1-10(2007) [PubMed: 17574350] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Cerebellum.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB222113 mRNA. Translation: BAF62358.1.
RefSeq	NP_001138305.1.
3D structure databases
SMR	A5A6I5. Positions 2-364.
ModBase	Search...
Protein-protein interaction databases
STRING	A5A6I5.
Genome annotation databases
Ensembl	ENSPTRT00000014733; ENSPTRP00000013648; ENSPTRG00000007983; Pan troglodytes. [Genome view] ENSPTRT00000064205; ENSPTRP00000055755; ENSPTRG00000007983; Pan troglodytes. [Genome view]
GeneID	454362.
KEGG	ptr:454362.
Organism-specific databases
CTD	454362.
Phylogenomic databases
eggNOG	prNOG06512.
InParanoid	A5A6I5.
Enzyme and pathway databases
BRENDA	4.1.2.13. 264977.
Family and domain databases
InterPro	IPR000741. Aldolase_I. IPR013785. Aldolase_TIM. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR11627. Aldolase_I. 1 hit.
Pfam	PF00274. Glycolytic. 1 hit. [Graphical view]
PROSITE	PS00158. ALDOLASE_CLASS_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALDOA_PANTR

Accession

Primary (citable) accession number: A5A6I5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	June 12, 2007
Last modified:	January 19, 2010
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)