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A5A6I1 (HPRT_PANTR) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hypoxanthine-guanine phosphoribosyltransferase

Short name=HGPRT
Short name=HGPRTase
EC=2.4.2.8
Gene names
Name:HPRT1
OrganismPan troglodytes (Chimpanzee) [Reference proteome]
Taxonomic identifier9598 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan

Protein attributes

Sequence length218 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway By similarity.

Catalytic activity

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.

GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.

Cofactor

Binds 2 magnesium ions per subunit. The magnesium ions are essentially bound to the substrate and have few direct interactions with the protein By similarity.

Pathway

Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Ontologies

Keywords
   Biological processPurine salvage
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
Nucleotide-binding
   Molecular functionGlycosyltransferase
Transferase
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processGMP catabolic process

Inferred from sequence or structural similarity. Source: UniProtKB

GMP salvage

Inferred from Biological aspect of Ancestor. Source: RefGenome

IMP metabolic process

Inferred from sequence or structural similarity. Source: UniProtKB

IMP salvage

Inferred from Biological aspect of Ancestor. Source: RefGenome

adenine salvage

Inferred from Biological aspect of Ancestor. Source: RefGenome

guanine salvage

Inferred from sequence or structural similarity. Source: UniProtKB

hypoxanthine metabolic process

Inferred from Biological aspect of Ancestor. Source: RefGenome

hypoxanthine salvage

Inferred from sequence or structural similarity. Source: UniProtKB

purine ribonucleoside salvage

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Cellular_componentcytosol

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionguanine phosphoribosyltransferase activity

Inferred from sequence or structural similarity. Source: UniProtKB

hypoxanthine phosphoribosyltransferase activity

Inferred from sequence or structural similarity. Source: UniProtKB

magnesium ion binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

nucleotide binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 218217Hypoxanthine-guanine phosphoribosyltransferase
PRO_0000295591

Regions

Nucleotide binding134 – 1429GMP By similarity
Nucleotide binding186 – 1883GMP By similarity

Sites

Active site1381Proton acceptor By similarity
Metal binding1941Magnesium By similarity
Binding site691GMP By similarity
Binding site1661GMP By similarity
Binding site1941GMP; via carbonyl oxygen By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue1031N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A5A6I1 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 02B94CE379DE5AF9

FASTA21824,567
        10         20         30         40         50         60 
MATRSPGVVI SDDEPGYDLD LFCIPNHYAE DLERVFIPHG LIMDRTERLA RDVMKEMGGH 

        70         80         90        100        110        120 
HIVALCVLKG GYKFFADLLD YIKALNRNSD RSIPMTVDFI RLKSYCNDQS TGDTKVIGGD 

       130        140        150        160        170        180 
DLSTLTGKNV LIVEDIIDTG KTMQTLLSLV RQYNPKMVKV ASLLVKRTPR SVGYKPDFVG 

       190        200        210 
FEIPDKFVVG YALDYNEYFR DLNHVCVISE TGKAKYKA 

« Hide

References

[1]"Mapping of chimpanzee full-length cDNAs onto the human genome unveils large potential divergence of the transcriptome."
Sakate R., Suto Y., Imanishi T., Tanoue T., Hida M., Hayasaka I., Kusuda J., Gojobori T., Hashimoto K., Hirai M.
Gene 399:1-10(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Cerebellum.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB222109 mRNA. Translation: BAF62354.1.
RefSeqNP_001104287.1. NM_001110817.1.
UniGenePtr.1948.

3D structure databases

ProteinModelPortalA5A6I1.
SMRA5A6I1. Positions 5-218.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9598.ENSPTRP00000041182.

Proteomic databases

PRIDEA5A6I1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID735894.
KEGGptr:735894.

Organism-specific databases

CTD3251.

Phylogenomic databases

eggNOGCOG0634.
HOGENOMHOG000236521.
HOVERGENHBG000242.
InParanoidA5A6I1.
KOK00760.

Enzyme and pathway databases

UniPathwayUPA00591; UER00648.

Family and domain databases

Gene3D3.40.50.2020. 1 hit.
InterProIPR005904. Hxn_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMSSF53271. SSF53271. 1 hit.
TIGRFAMsTIGR01203. HGPRTase. 1 hit.
PROSITEPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20903330.

Entry information

Entry nameHPRT_PANTR
AccessionPrimary (citable) accession number: A5A6I1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: June 12, 2007
Last modified: June 11, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways