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A5A6I0

- ACADM_PANTR

UniProt

A5A6I0 - ACADM_PANTR

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Protein
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
Gene
ACADM
Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

This enzyme is specific for acyl chain lengths of 4 to 16 By similarity.

Catalytic activityi

A medium-chain acyl-CoA + electron-transfer flavoprotein = a medium-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.

Cofactori

FAD By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei167 – 1671Substrate; via carbonyl oxygen By similarity
Binding sitei216 – 2161Substrate By similarity
Active sitei401 – 4011Proton acceptor By similarity
Binding sitei402 – 4021Substrate; via amide nitrogen By similarity
Binding sitei413 – 4131Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi158 – 16710FAD By similarity
Nucleotide bindingi191 – 1933FAD By similarity
Nucleotide bindingi306 – 3083FAD By similarity
Nucleotide bindingi316 – 3172FAD By similarity
Nucleotide bindingi374 – 3785FAD By similarity
Nucleotide bindingi403 – 4053FAD By similarity

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. medium-chain-acyl-CoA dehydrogenase activity Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. cardiac muscle cell differentiation Source: Ensembl
  2. carnitine biosynthetic process Source: Ensembl
  3. carnitine metabolic process, CoA-linked Source: Ensembl
  4. fatty acid beta-oxidation using acyl-CoA dehydrogenase Source: Ensembl
  5. glycogen biosynthetic process Source: Ensembl
  6. liver development Source: Ensembl
  7. medium-chain fatty acid catabolic process Source: Ensembl
  8. post-embryonic development Source: Ensembl
  9. regulation of gluconeogenesis Source: Ensembl
  10. response to cold Source: Ensembl
  11. response to starvation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00660.

Names & Taxonomyi

Protein namesi
Recommended name:
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (EC:1.3.8.7)
Short name:
MCAD
Gene namesi
Name:ACADM
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
ProteomesiUP000002277: Chromosome 1

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. axon Source: Ensembl
  2. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2525Mitochondrion By similarity
Add
BLAST
Chaini26 – 421396Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
PRO_0000295306Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei69 – 691N6-acetyllysine; alternate By similarity
Modified residuei69 – 691N6-succinyllysine; alternate By similarity
Modified residuei179 – 1791N6-succinyllysine By similarity
Modified residuei212 – 2121N6-acetyllysine; alternate By similarity
Modified residuei212 – 2121N6-succinyllysine; alternate By similarity
Modified residuei217 – 2171N6-acetyllysine; alternate By similarity
Modified residuei217 – 2171N6-succinyllysine; alternate By similarity
Modified residuei271 – 2711N6-acetyllysine; alternate By similarity
Modified residuei271 – 2711N6-succinyllysine; alternate By similarity
Modified residuei279 – 2791N6-acetyllysine By similarity
Modified residuei301 – 3011N6-acetyllysine By similarity

Post-translational modificationi

Acetylation at Lys-307 and Lys-311 in proximity of the cofactor-binding sites reduces catalytic activity. These sites are deacetylated by SIRT3 By similarity.

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiA5A6I0.

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000001508.

Structurei

3D structure databases

ProteinModelPortaliA5A6I0.
SMRiA5A6I0. Positions 34-421.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni278 – 2814Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1960.
HOGENOMiHOG000131659.
HOVERGENiHBG000224.
KOiK00249.
OMAiSAWEVDQ.
OrthoDBiEOG74FF0S.
TreeFamiTF105020.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
2.40.110.10. 1 hit.
InterProiIPR006089. Acyl-CoA_DH_CS.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view]
SUPFAMiSSF47203. SSF47203. 1 hit.
SSF56645. SSF56645. 1 hit.
PROSITEiPS00072. ACYL_COA_DH_1. 1 hit.
PS00073. ACYL_COA_DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A5A6I0-1 [UniParc]FASTAAdd to Basket

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MAAGFGRCCR VLRSISRFQW RSQHTKANRQ REPGLGFSFE FTEQQKEFQA    50
TARKFAREEI IPVAAEYDKT GEYPVPLIRR AWELGLMNTH IPENCGGLGL 100
GTFDACLISE ELAYGCTGVQ TAIEGNSLGQ MPIIIAGNDQ QKKKYLGRMT 150
EEPLMCAYCV TEPGAGSDVA GIKTKAEKKG DEYIINGQKM WITNGGKANW 200
YFLLARSDPD PKAPANKAFT GFIVEADTPG IQIGRKELNM GQRCSDTRGI 250
VFEDVKVPRE NVLIGDGAGF KVAMGAFDKT RPVVAAGAVG LAQRALDEAT 300
KYALERKTFG KLLVEHQAIS FMLAEMAMKV ELARMSYQRA AWEVDSGRRN 350
TYYASIAKAF AGDIANQLAT DAVQILGGNG FNTEYPVEKL MRDAKIYQIY 400
EGTSQIQRLI VAREHIDKYK N 421
Length:421
Mass (Da):46,607
Last modified:June 12, 2007 - v1
Checksum:iAF7FDB95417441DE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB222108 mRNA. Translation: BAF62353.1.
RefSeqiNP_001104286.1. NM_001110816.1.
UniGeneiPtr.3961.

Genome annotation databases

EnsembliENSPTRT00000059079; ENSPTRP00000052172; ENSPTRG00000000871.
GeneIDi469356.
KEGGiptr:469356.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB222108 mRNA. Translation: BAF62353.1 .
RefSeqi NP_001104286.1. NM_001110816.1.
UniGenei Ptr.3961.

3D structure databases

ProteinModelPortali A5A6I0.
SMRi A5A6I0. Positions 34-421.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9598.ENSPTRP00000001508.

Proteomic databases

PRIDEi A5A6I0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPTRT00000059079 ; ENSPTRP00000052172 ; ENSPTRG00000000871 .
GeneIDi 469356.
KEGGi ptr:469356.

Organism-specific databases

CTDi 34.

Phylogenomic databases

eggNOGi COG1960.
HOGENOMi HOG000131659.
HOVERGENi HBG000224.
KOi K00249.
OMAi SAWEVDQ.
OrthoDBi EOG74FF0S.
TreeFami TF105020.

Enzyme and pathway databases

UniPathwayi UPA00660 .

Miscellaneous databases

NextBioi 20846770.

Family and domain databases

Gene3Di 1.10.540.10. 1 hit.
2.40.110.10. 1 hit.
InterProi IPR006089. Acyl-CoA_DH_CS.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view ]
Pfami PF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47203. SSF47203. 1 hit.
SSF56645. SSF56645. 1 hit.
PROSITEi PS00072. ACYL_COA_DH_1. 1 hit.
PS00073. ACYL_COA_DH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mapping of chimpanzee full-length cDNAs onto the human genome unveils large potential divergence of the transcriptome."
    Sakate R., Suto Y., Imanishi T., Tanoue T., Hida M., Hayasaka I., Kusuda J., Gojobori T., Hashimoto K., Hirai M.
    Gene 399:1-10(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Cerebellum.

Entry informationi

Entry nameiACADM_PANTR
AccessioniPrimary (citable) accession number: A5A6I0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: June 12, 2007
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

A number of straight-chain acyl-CoA dehydrogenases of different substrate specificities are present in mammalian tissues.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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