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Protein

Growth hormone secretagogue receptor type 1

Gene

GHSR

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Growth hormone secretagogue receptor type 1
Short name:
GHS-R
Alternative name(s):
GH-releasing peptide receptor
Short name:
GHRP
Ghrelin receptor
Gene namesi
Name:GHSR
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome 14

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4040ExtracellularSequence analysisAdd
BLAST
Transmembranei41 – 6626Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini67 – 726CytoplasmicSequence analysis
Transmembranei73 – 9624Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini97 – 11721ExtracellularSequence analysisAdd
BLAST
Transmembranei118 – 13922Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini140 – 16223CytoplasmicSequence analysisAdd
BLAST
Transmembranei163 – 18321Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini184 – 21128ExtracellularSequence analysisAdd
BLAST
Transmembranei212 – 23524Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini236 – 26328CytoplasmicSequence analysisAdd
BLAST
Transmembranei264 – 28522Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini286 – 30217ExtracellularSequence analysisAdd
BLAST
Transmembranei303 – 32624Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini327 – 36640CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL5307.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 366366Growth hormone secretagogue receptor type 1PRO_0000310946Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi13 – 131N-linked (GlcNAc...)Sequence analysis
Glycosylationi27 – 271N-linked (GlcNAc...)Sequence analysis
Disulfide bondi116 ↔ 198PROSITE-ProRule annotation
Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000006345.

Chemistry

BindingDBiA5A4K9.

Structurei

3D structure databases

ProteinModelPortaliA5A4K9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000272571.
HOVERGENiHBG006538.
InParanoidiA5A4K9.
KOiK04284.
OMAiDTNECRA.
OrthoDBiEOG091G09KB.
TreeFamiTF332184.

Family and domain databases

InterProiIPR003905. GHS-R.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01417. GHSRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5A4K9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWNATPSEEP GSNLTRAELG WDAPPGNDSL ADELLQLFPA PLLAGVTATC
60 70 80 90 100
VALFVVGIAG NLLTMLVVSR FRELRTTTNL YLSSMAFSDL LIFLCMPLDL
110 120 130 140 150
VRLWQYRPWN FGDLLCKLFQ FVSESCTYAT VLTITALSVE RYFAICFPLR
160 170 180 190 200
AKVVVTKGRV KLVILVIWAL AFCSAGPIFV LVGVEHENGT DPQDTNECRA
210 220 230 240 250
TEFAVRSGLL TIMVWVSSVF FFLPVFCLTV LYSLIGRKLW RRKRGDGAVG
260 270 280 290 300
SSLRDQNHRQ TVKMLAVVVF AFILCWLPFH VGRYLFSKSF EPGSLEIAQI
310 320 330 340 350
SQYCNLVSFV LFYLSAAINP ILYNIMSKKY RVAVFKLLGF EPFSQRKLST
360
LKDESSRAWT KSSINT
Length:366
Mass (Da):41,132
Last modified:May 29, 2007 - v1
Checksum:iA884B4FBD5711B23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF526305 mRNA. Translation: ABP88929.1.
RefSeqiNP_001093438.1. NM_001099968.1.
XP_008264418.1. XM_008266196.1.
UniGeneiOcu.7151.

Genome annotation databases

EnsembliENSOCUT00000007339; ENSOCUP00000006345; ENSOCUG00000007340.
GeneIDi100101582.
KEGGiocu:100101582.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF526305 mRNA. Translation: ABP88929.1.
RefSeqiNP_001093438.1. NM_001099968.1.
XP_008264418.1. XM_008266196.1.
UniGeneiOcu.7151.

3D structure databases

ProteinModelPortaliA5A4K9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000006345.

Chemistry

BindingDBiA5A4K9.
ChEMBLiCHEMBL5307.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOCUT00000007339; ENSOCUP00000006345; ENSOCUG00000007340.
GeneIDi100101582.
KEGGiocu:100101582.

Organism-specific databases

CTDi2693.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000272571.
HOVERGENiHBG006538.
InParanoidiA5A4K9.
KOiK04284.
OMAiDTNECRA.
OrthoDBiEOG091G09KB.
TreeFamiTF332184.

Miscellaneous databases

PROiA5A4K9.

Family and domain databases

InterProiIPR003905. GHS-R.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01417. GHSRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGHSR_RABIT
AccessioniPrimary (citable) accession number: A5A4K9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: May 29, 2007
Last modified: September 7, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.