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Protein

POTE ankyrin domain family member F

Gene

POTEF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • retina homeostasis Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-31379-MONOMER.
SignaLinkiA5A3E0.

Names & Taxonomyi

Protein namesi
Recommended name:
POTE ankyrin domain family member F
Alternative name(s):
ANKRD26-like family C member 1B
Chimeric POTE-actin protein
Gene namesi
Name:POTEF
Synonyms:A26C1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:33905. POTEF.

Subcellular locationi

GO - Cellular componenti

  • blood microparticle Source: UniProtKB
  • cell cortex Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi728378.
OpenTargetsiENSG00000196604.
PharmGKBiPA164724818.

Polymorphism and mutation databases

BioMutaiPOTEF.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003078591 – 1075POTE ankyrin domain family member FAdd BLAST1075

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki684Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiA5A3E0.
MaxQBiA5A3E0.
PaxDbiA5A3E0.
PRIDEiA5A3E0.

PTM databases

iPTMnetiA5A3E0.
PhosphoSitePlusiA5A3E0.
SwissPalmiA5A3E0.

Expressioni

Tissue specificityi

Expressed in breast cancer cell lines (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000196604.
CleanExiHS_POTEF.
ExpressionAtlasiA5A3E0. baseline and differential.

Organism-specific databases

HPAiHPA041264.
HPA041271.
HPA042822.
HPA043260.

Interactioni

Protein-protein interaction databases

BioGridi608805. 62 interactors.
IntActiA5A3E0. 4 interactors.
STRINGi9606.ENSP00000350052.

Structurei

3D structure databases

ProteinModelPortaliA5A3E0.
SMRiA5A3E0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati172 – 201ANK 1Add BLAST30
Repeati205 – 234ANK 2Add BLAST30
Repeati238 – 267ANK 3Add BLAST30
Repeati271 – 300ANK 4Add BLAST30
Repeati304 – 333ANK 5Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni702 – 1075Actin-likeAdd BLAST374

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili399 – 435Sequence analysisAdd BLAST37
Coiled coili642 – 698Sequence analysisAdd BLAST57

Sequence similaritiesi

In the N-terminal section; belongs to the POTE family.Curated
In the C-terminal section; belongs to the actin family.Curated
Contains 5 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410ITJG. Eukaryota.
KOG0676. Eukaryota.
COG0666. LUCA.
COG5277. LUCA.
GeneTreeiENSGT00560000076605.
HOGENOMiHOG000115614.
InParanoidiA5A3E0.
KOiK17299.
OrthoDBiEOG091G077A.
PhylomeDBiA5A3E0.
TreeFamiTF354237.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00022. Actin. 1 hit.
PF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
SM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5A3E0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVEVDSMPA ASSVKKPFGL RSKMGKWCCR CFPCCRESGK SNVGTSGDHD
60 70 80 90 100
DSAMKTLRSK MGKWCRHCFP CCRGSGKSNV GASGDHDDSA MKTLRNKMGK
110 120 130 140 150
WCCHCFPCCR GSSKSKVGAW GDYDDSAFME PRYHVRGEDL DKLHRAAWWG
160 170 180 190 200
KVPRKDLIVM LRDTDVNKQD KQKRTALHLA SANGNSEVVK LLLDRRCQLN
210 220 230 240 250
VLDNKKRTAL IKAVQCQEDE CALMLLEHGT DPNIPDEYGN TTLHYAIYNE
260 270 280 290 300
DKLMAKALLL YGADIESKNK HGLTPLLLGV HEQKQQVVKF LIKKKANLNA
310 320 330 340 350
LDRYGRTALI LAVCCGSASI VSLLLEQNID VSSQDLSGQT AREYAVSSHH
360 370 380 390 400
HVICQLLSDY KEKQMLKISS ENSNPEQDLK LTSEEESQRF KGSENSQPEK
410 420 430 440 450
MSQEPEINKD GDREVEEEMK KHESNNVGLL ENLTNGVTAG NGDNGLIPQR
460 470 480 490 500
KSRTPENQQF PDNESEEYHR ICELLSDYKE KQMPKYSSEN SNPEQDLKLT
510 520 530 540 550
SEEESQRLKG SENGQPEKRS QEPEINKDGD RELENFMAIE EMKKHRSTHV
560 570 580 590 600
GFPENLTNGA TAGNGDDGLI PPRKSRTPES QQFPDTENEE YHSDEQNDTQ
610 620 630 640 650
KQFCEEQNTG ILHDEILIHE EKQIEVVEKM NSELSLSCKK EKDILHENST
660 670 680 690 700
LREEIAMLRL ELDTMKHQSQ LREKKYLEDI ESVKKRNDNL LKALQLNELT
710 720 730 740 750
MDDDTAVLVI DNGSGMCKAG FAGDDAPRAV FPSIVGRPRQ QGMMGGMHQK
760 770 780 790 800
ESYVGKEAQS KRGILTLKYP MEHGIITNWD DMEKIWHHTF YNELRVAPEE
810 820 830 840 850
HPVLLTEATL NPKANREKMT QIMFETFNTP AMYVAIQAVL SLYTSGRTTG
860 870 880 890 900
IVMDSGDGVT HTVPIYEGNA LPHATLRLDL AGRELPDYLM KILTEHGYRF
910 920 930 940 950
TTMAEREIVR DIKEKLCYVA LDFEQEMATV ASSSSLEKSY ELPDGQVITI
960 970 980 990 1000
GNERFRCPEA LFQPCFLGME SCGIHETTFN SIMKSDVDIR KDLYTNTVLS
1010 1020 1030 1040 1050
GGTTMYPGMA HRMQKEIAAL APSMMKIRII APPKRKYSVW VGGSILASLS
1060 1070
TFQQMWISKQ EYDESGPSIV HRKCL
Length:1,075
Mass (Da):121,445
Last modified:November 25, 2008 - v2
Checksum:i8833FF435D1B6902
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4E → G in ABP57734 (PubMed:17101985).Curated1
Sequence conflicti387S → L in ABP57734 (PubMed:17101985).Curated1
Sequence conflicti930V → A in ABP57734 (PubMed:17101985).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF523384 mRNA. Translation: ABP57734.1.
AC018804 Genomic DNA. No translation available.
AC018865 Genomic DNA. No translation available.
CCDSiCCDS46409.1.
RefSeqiNP_001093241.1. NM_001099771.2.
UniGeneiHs.580547.

Genome annotation databases

EnsembliENST00000409914; ENSP00000386786; ENSG00000196604.
GeneIDi728378.
KEGGihsa:728378.
UCSCiuc010fmh.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF523384 mRNA. Translation: ABP57734.1.
AC018804 Genomic DNA. No translation available.
AC018865 Genomic DNA. No translation available.
CCDSiCCDS46409.1.
RefSeqiNP_001093241.1. NM_001099771.2.
UniGeneiHs.580547.

3D structure databases

ProteinModelPortaliA5A3E0.
SMRiA5A3E0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi608805. 62 interactors.
IntActiA5A3E0. 4 interactors.
STRINGi9606.ENSP00000350052.

PTM databases

iPTMnetiA5A3E0.
PhosphoSitePlusiA5A3E0.
SwissPalmiA5A3E0.

Polymorphism and mutation databases

BioMutaiPOTEF.

Proteomic databases

EPDiA5A3E0.
MaxQBiA5A3E0.
PaxDbiA5A3E0.
PRIDEiA5A3E0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409914; ENSP00000386786; ENSG00000196604.
GeneIDi728378.
KEGGihsa:728378.
UCSCiuc010fmh.3. human.

Organism-specific databases

CTDi728378.
DisGeNETi728378.
GeneCardsiPOTEF.
H-InvDBHIX0030053.
HGNCiHGNC:33905. POTEF.
HPAiHPA041264.
HPA041271.
HPA042822.
HPA043260.
neXtProtiNX_A5A3E0.
OpenTargetsiENSG00000196604.
PharmGKBiPA164724818.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITJG. Eukaryota.
KOG0676. Eukaryota.
COG0666. LUCA.
COG5277. LUCA.
GeneTreeiENSGT00560000076605.
HOGENOMiHOG000115614.
InParanoidiA5A3E0.
KOiK17299.
OrthoDBiEOG091G077A.
PhylomeDBiA5A3E0.
TreeFamiTF354237.

Enzyme and pathway databases

BioCyciZFISH:G66-31379-MONOMER.
SignaLinkiA5A3E0.

Miscellaneous databases

GenomeRNAii728378.
PROiA5A3E0.

Gene expression databases

BgeeiENSG00000196604.
CleanExiHS_POTEF.
ExpressionAtlasiA5A3E0. baseline and differential.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00022. Actin. 1 hit.
PF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
SM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPOTEF_HUMAN
AccessioniPrimary (citable) accession number: A5A3E0
Secondary accession number(s): A6NC34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: November 25, 2008
Last modified: November 30, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Results from the insertion of a beta-actin fragment at the C-terminus in the POTEE paralog gene leading to the formation of a new functional chimeric protein. This insertion occured before the divergence of the Old World monkeys and apes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.