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Protein

Beta-lactamase

Gene

blaACC-4

Organism
Escherichia coli
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
Biological processAntibiotic resistanceUniRule annotation

Protein family/group databases

MEROPSiS12.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamaseUniRule annotation (EC:3.5.2.6UniRule annotation)
Gene namesi
Name:blaACC-4Imported
Encoded oniPlasmid p3521Imported
Plasmid pR3521Imported
OrganismiEscherichia coliImported
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5305.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500763517024 – 386Beta-lactamaseSequence analysisAdd BLAST363

Interactioni

Chemistry databases

BindingDBiA4ZYU9.

Structurei

3D structure databases

ProteinModelPortaliA4ZYU9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 379Beta-lactamaseInterPro annotationAdd BLAST345

Sequence similaritiesi

Belongs to the class-C beta-lactamase family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

KOiK19214.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiView protein in InterPro
IPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR001586. Beta-lactam_class-C_AS.
PfamiView protein in Pfam
PF00144. Beta-lactamase. 1 hit.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiView protein in PROSITE
PS00336. BETA_LACTAMASE_C. 1 hit.

Sequencei

Sequence statusi: Complete.

A4ZYU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNTLKLLSV ITCLAATVQG ALAANIDESK IKDTVDDLIQ PLMQKNNIPG
60 70 80 90 100
MSVAVTVNGK NYIYNYGLAA KQPQQPVTEN TLFEVGSLSK TFAATLASYA
110 120 130 140 150
QVSGKLSLDQ SVSHYVPELR GSSFDHVSVL NVGTHTSGLQ LFMPEDIKNT
160 170 180 190 200
TQLMAYLKAW KPADAAGTHR VYSNIGTGLL GMIAAKSLGV SYEDAIEKTL
210 220 230 240 250
LPQLGMHHSY LKVPADQMEN YAWGYNKKDE PVHGNMEILG NEAYGIKTTS
260 270 280 290 300
SDLLRYVQAN MGQLKLDANA KMQQALTATH TGYFKSGEIT QDLMWEQLPY
310 320 330 340 350
PVSLPNLLTG NDMAMTKSVA TPIVPPLPPQ ENVWINKTGS TNGFGAYIAF
360 370 380
VPAKKMGIVM LANKNYSIDQ RVTVAYKILS SLEGNK
Length:386
Mass (Da):42,015
Last modified:May 29, 2007 - v1
Checksum:i03EB6007884723B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF504260 Genomic DNA. Translation: ABP49606.1.
GU256641 Genomic DNA. Translation: ADB84938.1.
RefSeqiWP_013512950.1. NC_014843.1.
YP_004119738.1. NC_014843.1.

Genome annotation databases

GeneIDi10076149.
KEGGiag:ABP49606.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF504260 Genomic DNA. Translation: ABP49606.1.
GU256641 Genomic DNA. Translation: ADB84938.1.
RefSeqiWP_013512950.1. NC_014843.1.
YP_004119738.1. NC_014843.1.

3D structure databases

ProteinModelPortaliA4ZYU9.
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

BindingDBiA4ZYU9.
ChEMBLiCHEMBL5305.

Protein family/group databases

MEROPSiS12.006.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi10076149.
KEGGiag:ABP49606.

Phylogenomic databases

KOiK19214.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiView protein in InterPro
IPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR001586. Beta-lactam_class-C_AS.
PfamiView protein in Pfam
PF00144. Beta-lactamase. 1 hit.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiView protein in PROSITE
PS00336. BETA_LACTAMASE_C. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA4ZYU9_ECOLX
AccessioniPrimary (citable) accession number: A4ZYU9
Entry historyiIntegrated into UniProtKB/TrEMBL: May 29, 2007
Last sequence update: May 29, 2007
Last modified: November 30, 2016
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

PlasmidImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.