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Protein

Envelope glycoprotein gp160

Gene

env

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosisUniRule annotationSAAS annotation, Fusion of virus membrane with host membraneUniRule annotationSAAS annotation, Host-virus interaction, Viral attachment to host cellUniRule annotationSAAS annotation, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein gp160UniRule annotation
Cleaved into the following 2 chains:
Surface protein gp120UniRule annotation
Short name:
SUUniRule annotation
Alternative name(s):
Glycoprotein 120UniRule annotation
Short name:
gp120UniRule annotation
Transmembrane protein gp41UniRule annotation
Short name:
TMUniRule annotation
Gene namesi
Name:envImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

A4ZPW6:
  • Host cell membrane SAAS annotation; Peripheral membrane protein SAAS annotation
A4ZPW6:
  • Host cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation
A4ZPW6:
  • Host endosome membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation
A4ZPW6:
  • Virion membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei508 – 531HelicalUniRule annotationAdd BLAST24
Transmembranei674 – 701HelicalUniRule annotationAdd BLAST28

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membraneUniRule annotationSAAS annotation, Host endosomeUniRule annotationSAAS annotation, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotationImported, Virion

PTM / Processingi

Keywords - PTMi

Cleavage on pair of basic residuesUniRule annotation, Disulfide bondSAAS annotation

Interactioni

Subunit structurei

The mature envelope protein (Env) consists of a homotrimer of non-covalently associated gp120-gp41 heterodimers. The resulting complex protrudes from the virus surface as a spike.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA4ZPW6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 149GP120InterPro annotationAdd BLAST117
Domaini151 – 507GP120InterPro annotationAdd BLAST357
Domaini526 – 716GP41InterPro annotationAdd BLAST191

Domaini

The 17 amino acids long immunosuppressive region is present in many retroviral envelope proteins. Synthetic peptides derived from this relatively conserved sequence inhibit immune function in vitro and in vivo.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

CDDicd09909. HIV-1-like_HR1-HR2. 1 hit.
Gene3Di2.170.40.20. 2 hits.
InterProiView protein in InterPro
IPR036377. Gp120_core_sf.
IPR000328. GP41-like.
IPR000777. HIV1_Gp120.
PfamiView protein in Pfam
PF00516. GP120. 2 hits.
PF00517. GP41. 1 hit.
SUPFAMiSSF56502. SSF56502. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A4ZPW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVMETRKNY QHLWKWGTML LGMLTICSAA EDLWVTVYYG VPVWKDASTT
60 70 80 90 100
LFCASEAKAY DTEAHNVWAT HACVPTDPNP QEIVLQNVTE GFNMWKNNMV
110 120 130 140 150
EQMHEDIISL WDQSLKPCVK LTPLCVTLNC TTANANSTAN ATSTTSTTST
160 170 180 190 200
DMKNCSFNIT TDMRDKVQKQ HALFYSLDVV PIDNSNNSYR LISCNTSVIT
210 220 230 240 250
QACPKISFEP IPIHYCAPAG FAIIKCNDKN FAGIGTCKNV STVQCTHGVR
260 270 280 290 300
PVVSTQLLLN GGLTEGEVVI KSANFSDNTK TIIVQLSESI EINCTRPSNN
310 320 330 340 350
TRKSITIGPG RAFYTTGDII GDIRRAHCNI SGAKWNNTLR RIAEKLKVQY
360 370 380 390 400
ENRTIVFNAS SGGDPEVVMH TFNCGGEFFY CNTTQLFNST FNSTWERETN
410 420 430 440 450
TTELNTNITI TLPCRIKQII NMWQEVGKAM YAPPIRGQIR CSSNITGLLL
460 470 480 490 500
TRDGSHNNNT TETFRPGGGD MRDNWRSELY KYKVVKIEPL GIAPTKAKRR
510 520 530 540 550
VVQREKRAVG LGAVFLGFLG AAGSTMGAAS ITLTVQARQL LSGIVQQQRN
560 570 580 590 600
LLNAIEAQQH LLQLTVWGIK QLQARVLAIE RYLKDQQLLG IWGCSGKLIC
610 620 630 640 650
TTAVPWNASW SNKNLSQIWD NMTWMEWEKE IDNYTGLIYN LLEISQNQQE
660 670 680 690 700
KNEQELLELD KWASLWNWFD ITSWLWYIKI FIIIIGGLIS LRIICAVINI
710 720 730 740 750
VNKVRQRYSP LSFQTLLPTP RGPDRPERIE EEDRDRDRDT SVRLVTGFLA

LI
Length:752
Mass (Da):84,767
Last modified:May 29, 2007 - v1
Checksum:i6A164454505D5550
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF210728 Genomic DNA. Translation: ABP57176.1.

Similar proteinsi

Entry informationi

Entry nameiA4ZPW6_9HIV1
AccessioniPrimary (citable) accession number: A4ZPW6
Entry historyiIntegrated into UniProtKB/TrEMBL: May 29, 2007
Last sequence update: May 29, 2007
Last modified: October 25, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation