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A4ZCW5

- VP2_ROTH3

UniProt

A4ZCW5 - VP2_ROTH3

Protein

Inner capsid protein VP2

Gene
N/A
Organism
Rotavirus A (strain Human/Japan/AU-1/1982 G3-P3[9]-I3-R3-C3-M3-A3-N3-T3-E3-H3) (RV-A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (29 May 2007)
      Previous versions | rss
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    Functioni

    Inner capsid protein that self assembles to form an icosahedral capsid with a T=2 symmetry, which consists of 120 copies of VP2, with channels at each of its five-fold vertices. This capsid constitutes the innermost concentric layer of the viral mature particle. It encapsidates the polymerase VP1, the capping enzyme VP3 and the genomic dsRNA, thereby defining the core. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP2 is required for the replicase activity of VP1 polymerase. It probably plays a role in the coordination of packaging and genome replication by controlling the initiation of minus-strand synthesis. Binding to the polymerase VP1 presumably activates the autoinhibited VP1-RNA complex which will start the synthesis of the complementary minus-strand By similarity.By similarity

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inner capsid protein VP2
    OrganismiRotavirus A (strain Human/Japan/AU-1/1982 G3-P3[9]-I3-R3-C3-M3-A3-N3-T3-E3-H3) (RV-A)
    Taxonomic identifieri39013 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusRotavirus A
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000001454: Genome

    Subcellular locationi

    Virion Curated
    Note: Inner capsid protein. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.

    GO - Cellular componenti

    1. viral inner capsid Source: UniProtKB-KW
    2. viral nucleocapsid Source: InterPro

    Keywords - Cellular componenti

    Capsid protein, Inner capsid protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 887887Inner capsid protein VP2PRO_0000368056Add
    BLAST

    Interactioni

    Subunit structurei

    Dimer Potential. Interacts with VP1; this interaction presumably activates VP1. Interacts with VP3. Interacts with VP6. Interacts with NSP5 By similarity.By similarityCurated

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 9999Interaction with VP1 and VP3By similarityAdd
    BLAST
    Regioni401 – 42121HydrophobicBy similarityAdd
    BLAST
    Regioni429 – 44921HydrophobicBy similarityAdd
    BLAST
    Regioni543 – 56422Leucine-zipper 1Sequence AnalysisAdd
    BLAST
    Regioni672 – 69322Leucine-zipper 2Sequence AnalysisAdd
    BLAST

    Domaini

    The N-terminus is involved in VP1 binding.By similarity

    Sequence similaritiesi

    Belongs to the rotavirus VP2 family.Curated

    Keywords - Domaini

    Repeat

    Family and domain databases

    InterProiIPR007779. Rotavirus_VP2.
    [Graphical view]
    PfamiPF05087. Rota_VP2. 1 hit.
    [Graphical view]
    ProDomiPD008866. Rota_VP2. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    A4ZCW5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAYRKRGARR ETNLKQDDRM QEKEENKSTN SVIENKNGTK TQLSEKVLSQ    50
    KEEVITDNQE ETRIADEVKK SNKEESKQLL EVLKTKEEHQ KEVQYEILQK 100
    TIPTFEPKES ILKKLEDIKP EQAKKQTKLF RIFEPKQLPI YRANGEKELR 150
    NRWYWKLKRD TLPDGDYDVR EYFLNLYDQV LTEMPDYLLL KDMAVENKNS 200
    RDAGKVVDSE TAAICDAIFQ DEETEGVVRR FIAEMRQRVQ ADQNVVNYPS 250
    ILHPIDHAFN EYFLQHQLVE PLNNDIIFNY IPERIRNDVN YILNMDRNLP 300
    STARYIRPNL LQDRLNLHDN FESLWDTITT SNYILARSVV PDLKELVSTE 350
    AQIQKMSQDL QLEALTIQSE TQFLTGINSQ AANDCFKTLI AAMLSQRTMS 400
    LDFVTTNYMS LISGMWLLTV IPNDMFIRES LVACQLAIIN TIIYPAFGMQ 450
    RMHYRNGDPQ TPFQIAEQQI QNFQVANWLH FVNNNQFRQV IIDGVLNQVL 500
    NDNIRNGHVV NQLMEALMQL SRQQFPTMPV DYKRSIQRGI LLLSNRLGQL 550
    VDLTRLLAYN YETLMACITM NMQHVQTLTT EKLQLTSVTS LCMLIGNATV 600
    IPSPQTLFHY YNVNVNFHSN YNERINDAVA IITAANRLNL YQKKMKSIVE 650
    DFLKRLQIFD VSRVPDDQMY RLRDRLRLLP VEIRRLDIFN LILMNMEQIE 700
    RASDKIAQGV IIAYRDMQLE RDEMYGYVNI ARNLDGFQQI NLEELMRTGD 750
    YAQITNMLLN NQPVALVGAL PFITDSSVIS LIAKLDATVF AQIVKLRKVD 800
    TLKPILYKIN SDSNDFYLVA NYDWVPTSTT KVYKQVPQQF DFRASMHMLT 850
    SNLTFTVYSD LLAFVSADTV EPINAVAFDN MRIMNEL 887
    Length:887
    Mass (Da):103,235
    Last modified:May 29, 2007 - v1
    Checksum:i433AB813153C53B4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ490536 Genomic RNA. Translation: ABF67543.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ490536 Genomic RNA. Translation: ABF67543.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR007779. Rotavirus_VP2.
    [Graphical view ]
    Pfami PF05087. Rota_VP2. 1 hit.
    [Graphical view ]
    ProDomi PD008866. Rota_VP2. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Full genome-based classification of rotaviruses reveals a common origin between human Wa-Like and porcine rotavirus strains and human DS-1-like and bovine rotavirus strains."
      Matthijnssens J., Ciarlet M., Heiman E.M., Arijs I., Delbeke T., McDonald S.M., Palombo E.A., Iturriza-Gomara M., Maes P., Patton J.T., Rahman M., Van Ranst M.
      J. Virol. 82:3204-3219(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiVP2_ROTH3
    AccessioniPrimary (citable) accession number: A4ZCW5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3