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A4Z6T7

- A4Z6T7_HUMAN

UniProt

A4Z6T7 - A4Z6T7_HUMAN

Protein
Submitted name:

Arylamine N-acetyltransferase 2

Gene

NAT2

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (29 May 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. acetyltransferase activity Source: InterPro

    Keywords - Molecular functioni

    AcyltransferaseUniRule annotation, Transferase

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Arylamine N-acetyltransferase 2Imported
    Gene namesi
    Name:NAT2Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA18.

    Expressioni

    Gene expression databases

    ArrayExpressiA4Z6T7.
    BgeeiA4Z6T7.

    Structurei

    3D structure databases

    ProteinModelPortaliA4Z6T7.
    SMRiA4Z6T7. Positions 2-290.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the arylamine N-acetyltransferase family.UniRule annotation

    Phylogenomic databases

    HOVERGENiHBG000165.
    KOiK00622.
    OMAiFILTYRK.
    PhylomeDBiA4Z6T7.

    Family and domain databases

    InterProiIPR001447. Arylamine_N-AcTrfase.
    [Graphical view]
    PANTHERiPTHR11786. PTHR11786. 1 hit.
    PfamiPF00797. Acetyltransf_2. 1 hit.
    [Graphical view]
    PRINTSiPR01543. ANATRNSFRASE.

    Sequencei

    Sequence statusi: Complete.

    A4Z6T7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDIEAYFERI GYKNSRNKLD LETLTDILEH QIRAVPFENL NMHCGQAMEL    50
    GLEAIFDHIV RRNRGGWCLQ VNQLLYWALT TIGFQTTMLG GYFYIPPVNK 100
    YSTGMVHLLL QVTIDGRNYI VDAGSGSSSQ MWQPLELISG KDQPQVPCIF 150
    CLTEERGIWY LDQIRREQYI TNKEFLNSHL LPKKKHQKIY LFTLEPRTIE 200
    DFESMNTYLQ TSPTSSFITT SFCSLQTPEG VYCLVGFILT YRKFNYKDNT 250
    DLVEFKTLTE EEVEEVLRNI FKISLGRNLV PKPGDGSLTI 290
    Length:290
    Mass (Da):33,571
    Last modified:May 29, 2007 - v1
    Checksum:iFAEE3BC2107F000E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ472738 Genomic DNA. Translation: ABF01136.1.
    DQ472742 Genomic DNA. Translation: ABF01140.1.
    DQ472746 Genomic DNA. Translation: ABF01144.1.
    DQ472749 Genomic DNA. Translation: ABF01147.1.
    DQ472754 Genomic DNA. Translation: ABF01152.1.
    DQ472755 Genomic DNA. Translation: ABF01153.1.
    DQ472768 Genomic DNA. Translation: ABF01166.1.
    DQ472778 Genomic DNA. Translation: ABF01176.1.
    DQ472793 Genomic DNA. Translation: ABF01191.1.
    DQ472796 Genomic DNA. Translation: ABF01194.1.
    DQ472798 Genomic DNA. Translation: ABF01196.1.
    DQ472804 Genomic DNA. Translation: ABF01202.1.
    DQ472808 Genomic DNA. Translation: ABF01206.1.
    DQ472812 Genomic DNA. Translation: ABF01210.1.
    DQ472813 Genomic DNA. Translation: ABF01211.1.
    DQ472816 Genomic DNA. Translation: ABF01214.1.
    DQ472820 Genomic DNA. Translation: ABF01218.1.
    DQ472832 Genomic DNA. Translation: ABF01230.1.
    DQ472864 Genomic DNA. Translation: ABF01262.1.
    DQ472868 Genomic DNA. Translation: ABF01266.1.
    DQ472869 Genomic DNA. Translation: ABF01267.1.
    DQ472873 Genomic DNA. Translation: ABF01271.1.
    DQ472881 Genomic DNA. Translation: ABF01279.1.
    DQ472892 Genomic DNA. Translation: ABF01290.1.
    DQ472906 Genomic DNA. Translation: ABF01304.1.
    DQ472914 Genomic DNA. Translation: ABF01312.1.
    DQ472929 Genomic DNA. Translation: ABF01327.1.
    DQ472941 Genomic DNA. Translation: ABF01339.1.
    DQ472949 Genomic DNA. Translation: ABF01347.1.
    DQ472951 Genomic DNA. Translation: ABF01349.1.
    DQ472952 Genomic DNA. Translation: ABF01350.1.
    DQ472961 Genomic DNA. Translation: ABF01359.1.
    DQ472964 Genomic DNA. Translation: ABF01362.1.
    DQ472980 Genomic DNA. Translation: ABF01378.1.
    DQ472996 Genomic DNA. Translation: ABF01394.1.
    DQ473006 Genomic DNA. Translation: ABF01404.1.
    DQ473012 Genomic DNA. Translation: ABF01410.1.
    DQ473015 Genomic DNA. Translation: ABF01413.1.
    DQ473016 Genomic DNA. Translation: ABF01414.1.
    DQ473026 Genomic DNA. Translation: ABF01424.1.
    DQ473027 Genomic DNA. Translation: ABF01425.1.
    DQ473030 Genomic DNA. Translation: ABF01428.1.
    DQ473031 Genomic DNA. Translation: ABF01429.1.
    DQ473034 Genomic DNA. Translation: ABF01432.1.
    DQ473039 Genomic DNA. Translation: ABF01437.1.
    DQ473044 Genomic DNA. Translation: ABF01442.1.
    DQ473095 Genomic DNA. Translation: ABF01493.1.
    DQ473107 Genomic DNA. Translation: ABF01505.1.
    DQ473111 Genomic DNA. Translation: ABF01509.1.
    DQ473112 Genomic DNA. Translation: ABF01510.1.
    DQ473113 Genomic DNA. Translation: ABF01511.1.
    DQ473114 Genomic DNA. Translation: ABF01512.1.
    DQ473115 Genomic DNA. Translation: ABF01513.1.
    DQ473130 Genomic DNA. Translation: ABF01528.1.
    DQ473134 Genomic DNA. Translation: ABF01532.1.
    DQ473136 Genomic DNA. Translation: ABF01534.1.
    DQ473139 Genomic DNA. Translation: ABF01537.1.
    DQ473143 Genomic DNA. Translation: ABF01541.1.
    DQ473144 Genomic DNA. Translation: ABF01542.1.
    DQ473146 Genomic DNA. Translation: ABF01544.1.
    DQ473149 Genomic DNA. Translation: ABF01547.1.
    DQ473152 Genomic DNA. Translation: ABF01550.1.
    DQ473153 Genomic DNA. Translation: ABF01551.1.
    DQ473154 Genomic DNA. Translation: ABF01552.1.
    DQ473155 Genomic DNA. Translation: ABF01553.1.
    DQ473159 Genomic DNA. Translation: ABF01557.1.
    DQ473163 Genomic DNA. Translation: ABF01561.1.
    DQ473187 Genomic DNA. Translation: ABF01585.1.
    DQ473208 Genomic DNA. Translation: ABF01606.1.
    DQ473212 Genomic DNA. Translation: ABF01610.1.
    DQ473213 Genomic DNA. Translation: ABF01611.1.
    DQ473216 Genomic DNA. Translation: ABF01614.1.
    DQ473217 Genomic DNA. Translation: ABF01615.1.
    DQ473219 Genomic DNA. Translation: ABF01617.1.
    DQ473230 Genomic DNA. Translation: ABF01628.1.
    DQ473233 Genomic DNA. Translation: ABF01631.1.
    DQ473235 Genomic DNA. Translation: ABF01633.1.
    DQ473236 Genomic DNA. Translation: ABF01634.1.
    DQ473238 Genomic DNA. Translation: ABF01636.1.
    DQ473256 Genomic DNA. Translation: ABF01654.1.
    DQ473258 Genomic DNA. Translation: ABF01656.1.
    DQ473261 Genomic DNA. Translation: ABF01659.1.
    DQ473262 Genomic DNA. Translation: ABF01660.1.
    DQ473264 Genomic DNA. Translation: ABF01662.1.
    DQ904040 Genomic DNA. Translation: ABK34557.1.
    DQ904041 Genomic DNA. Translation: ABK34558.1.
    DQ904042 Genomic DNA. Translation: ABK34559.1.
    DQ904043 Genomic DNA. Translation: ABK34560.1.
    DQ904044 Genomic DNA. Translation: ABK34561.1.
    DQ904046 Genomic DNA. Translation: ABK34563.1.
    DQ904048 Genomic DNA. Translation: ABK34565.1.
    DQ904050 Genomic DNA. Translation: ABK34567.1.
    DQ904053 Genomic DNA. Translation: ABK34570.1.
    DQ904080 Genomic DNA. Translation: ABK34597.1.
    DQ904082 Genomic DNA. Translation: ABK34599.1.
    DQ904084 Genomic DNA. Translation: ABK34601.1.
    DQ904086 Genomic DNA. Translation: ABK34603.1.
    DQ904088 Genomic DNA. Translation: ABK34605.1.
    DQ904169 Genomic DNA. Translation: ABK34686.1.
    DQ904171 Genomic DNA. Translation: ABK34688.1.
    DQ904173 Genomic DNA. Translation: ABK34690.1.
    DQ904175 Genomic DNA. Translation: ABK34692.1.
    DQ904177 Genomic DNA. Translation: ABK34694.1.
    DQ904179 Genomic DNA. Translation: ABK34696.1.
    DQ904181 Genomic DNA. Translation: ABK34698.1.
    DQ904183 Genomic DNA. Translation: ABK34700.1.
    DQ904185 Genomic DNA. Translation: ABK34702.1.
    DQ904187 Genomic DNA. Translation: ABK34704.1.
    DQ904220 Genomic DNA. Translation: ABK34737.1.
    RefSeqiNP_000006.2. NM_000015.2.
    UniGeneiHs.2.

    Genome annotation databases

    GeneIDi10.
    KEGGihsa:10.
    UCSCiuc003wyw.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ472738 Genomic DNA. Translation: ABF01136.1 .
    DQ472742 Genomic DNA. Translation: ABF01140.1 .
    DQ472746 Genomic DNA. Translation: ABF01144.1 .
    DQ472749 Genomic DNA. Translation: ABF01147.1 .
    DQ472754 Genomic DNA. Translation: ABF01152.1 .
    DQ472755 Genomic DNA. Translation: ABF01153.1 .
    DQ472768 Genomic DNA. Translation: ABF01166.1 .
    DQ472778 Genomic DNA. Translation: ABF01176.1 .
    DQ472793 Genomic DNA. Translation: ABF01191.1 .
    DQ472796 Genomic DNA. Translation: ABF01194.1 .
    DQ472798 Genomic DNA. Translation: ABF01196.1 .
    DQ472804 Genomic DNA. Translation: ABF01202.1 .
    DQ472808 Genomic DNA. Translation: ABF01206.1 .
    DQ472812 Genomic DNA. Translation: ABF01210.1 .
    DQ472813 Genomic DNA. Translation: ABF01211.1 .
    DQ472816 Genomic DNA. Translation: ABF01214.1 .
    DQ472820 Genomic DNA. Translation: ABF01218.1 .
    DQ472832 Genomic DNA. Translation: ABF01230.1 .
    DQ472864 Genomic DNA. Translation: ABF01262.1 .
    DQ472868 Genomic DNA. Translation: ABF01266.1 .
    DQ472869 Genomic DNA. Translation: ABF01267.1 .
    DQ472873 Genomic DNA. Translation: ABF01271.1 .
    DQ472881 Genomic DNA. Translation: ABF01279.1 .
    DQ472892 Genomic DNA. Translation: ABF01290.1 .
    DQ472906 Genomic DNA. Translation: ABF01304.1 .
    DQ472914 Genomic DNA. Translation: ABF01312.1 .
    DQ472929 Genomic DNA. Translation: ABF01327.1 .
    DQ472941 Genomic DNA. Translation: ABF01339.1 .
    DQ472949 Genomic DNA. Translation: ABF01347.1 .
    DQ472951 Genomic DNA. Translation: ABF01349.1 .
    DQ472952 Genomic DNA. Translation: ABF01350.1 .
    DQ472961 Genomic DNA. Translation: ABF01359.1 .
    DQ472964 Genomic DNA. Translation: ABF01362.1 .
    DQ472980 Genomic DNA. Translation: ABF01378.1 .
    DQ472996 Genomic DNA. Translation: ABF01394.1 .
    DQ473006 Genomic DNA. Translation: ABF01404.1 .
    DQ473012 Genomic DNA. Translation: ABF01410.1 .
    DQ473015 Genomic DNA. Translation: ABF01413.1 .
    DQ473016 Genomic DNA. Translation: ABF01414.1 .
    DQ473026 Genomic DNA. Translation: ABF01424.1 .
    DQ473027 Genomic DNA. Translation: ABF01425.1 .
    DQ473030 Genomic DNA. Translation: ABF01428.1 .
    DQ473031 Genomic DNA. Translation: ABF01429.1 .
    DQ473034 Genomic DNA. Translation: ABF01432.1 .
    DQ473039 Genomic DNA. Translation: ABF01437.1 .
    DQ473044 Genomic DNA. Translation: ABF01442.1 .
    DQ473095 Genomic DNA. Translation: ABF01493.1 .
    DQ473107 Genomic DNA. Translation: ABF01505.1 .
    DQ473111 Genomic DNA. Translation: ABF01509.1 .
    DQ473112 Genomic DNA. Translation: ABF01510.1 .
    DQ473113 Genomic DNA. Translation: ABF01511.1 .
    DQ473114 Genomic DNA. Translation: ABF01512.1 .
    DQ473115 Genomic DNA. Translation: ABF01513.1 .
    DQ473130 Genomic DNA. Translation: ABF01528.1 .
    DQ473134 Genomic DNA. Translation: ABF01532.1 .
    DQ473136 Genomic DNA. Translation: ABF01534.1 .
    DQ473139 Genomic DNA. Translation: ABF01537.1 .
    DQ473143 Genomic DNA. Translation: ABF01541.1 .
    DQ473144 Genomic DNA. Translation: ABF01542.1 .
    DQ473146 Genomic DNA. Translation: ABF01544.1 .
    DQ473149 Genomic DNA. Translation: ABF01547.1 .
    DQ473152 Genomic DNA. Translation: ABF01550.1 .
    DQ473153 Genomic DNA. Translation: ABF01551.1 .
    DQ473154 Genomic DNA. Translation: ABF01552.1 .
    DQ473155 Genomic DNA. Translation: ABF01553.1 .
    DQ473159 Genomic DNA. Translation: ABF01557.1 .
    DQ473163 Genomic DNA. Translation: ABF01561.1 .
    DQ473187 Genomic DNA. Translation: ABF01585.1 .
    DQ473208 Genomic DNA. Translation: ABF01606.1 .
    DQ473212 Genomic DNA. Translation: ABF01610.1 .
    DQ473213 Genomic DNA. Translation: ABF01611.1 .
    DQ473216 Genomic DNA. Translation: ABF01614.1 .
    DQ473217 Genomic DNA. Translation: ABF01615.1 .
    DQ473219 Genomic DNA. Translation: ABF01617.1 .
    DQ473230 Genomic DNA. Translation: ABF01628.1 .
    DQ473233 Genomic DNA. Translation: ABF01631.1 .
    DQ473235 Genomic DNA. Translation: ABF01633.1 .
    DQ473236 Genomic DNA. Translation: ABF01634.1 .
    DQ473238 Genomic DNA. Translation: ABF01636.1 .
    DQ473256 Genomic DNA. Translation: ABF01654.1 .
    DQ473258 Genomic DNA. Translation: ABF01656.1 .
    DQ473261 Genomic DNA. Translation: ABF01659.1 .
    DQ473262 Genomic DNA. Translation: ABF01660.1 .
    DQ473264 Genomic DNA. Translation: ABF01662.1 .
    DQ904040 Genomic DNA. Translation: ABK34557.1 .
    DQ904041 Genomic DNA. Translation: ABK34558.1 .
    DQ904042 Genomic DNA. Translation: ABK34559.1 .
    DQ904043 Genomic DNA. Translation: ABK34560.1 .
    DQ904044 Genomic DNA. Translation: ABK34561.1 .
    DQ904046 Genomic DNA. Translation: ABK34563.1 .
    DQ904048 Genomic DNA. Translation: ABK34565.1 .
    DQ904050 Genomic DNA. Translation: ABK34567.1 .
    DQ904053 Genomic DNA. Translation: ABK34570.1 .
    DQ904080 Genomic DNA. Translation: ABK34597.1 .
    DQ904082 Genomic DNA. Translation: ABK34599.1 .
    DQ904084 Genomic DNA. Translation: ABK34601.1 .
    DQ904086 Genomic DNA. Translation: ABK34603.1 .
    DQ904088 Genomic DNA. Translation: ABK34605.1 .
    DQ904169 Genomic DNA. Translation: ABK34686.1 .
    DQ904171 Genomic DNA. Translation: ABK34688.1 .
    DQ904173 Genomic DNA. Translation: ABK34690.1 .
    DQ904175 Genomic DNA. Translation: ABK34692.1 .
    DQ904177 Genomic DNA. Translation: ABK34694.1 .
    DQ904179 Genomic DNA. Translation: ABK34696.1 .
    DQ904181 Genomic DNA. Translation: ABK34698.1 .
    DQ904183 Genomic DNA. Translation: ABK34700.1 .
    DQ904185 Genomic DNA. Translation: ABK34702.1 .
    DQ904187 Genomic DNA. Translation: ABK34704.1 .
    DQ904220 Genomic DNA. Translation: ABK34737.1 .
    RefSeqi NP_000006.2. NM_000015.2.
    UniGenei Hs.2.

    3D structure databases

    ProteinModelPortali A4Z6T7.
    SMRi A4Z6T7. Positions 2-290.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    DNASUi 10.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 10.
    KEGGi hsa:10.
    UCSCi uc003wyw.1. human.

    Organism-specific databases

    CTDi 10.
    PharmGKBi PA18.

    Phylogenomic databases

    HOVERGENi HBG000165.
    KOi K00622.
    OMAi FILTYRK.
    PhylomeDBi A4Z6T7.

    Miscellaneous databases

    GenomeRNAii 10.
    NextBioi 17.

    Gene expression databases

    ArrayExpressi A4Z6T7.
    Bgeei A4Z6T7.

    Family and domain databases

    InterProi IPR001447. Arylamine_N-AcTrfase.
    [Graphical view ]
    PANTHERi PTHR11786. PTHR11786. 1 hit.
    Pfami PF00797. Acetyltransf_2. 1 hit.
    [Graphical view ]
    PRINTSi PR01543. ANATRNSFRASE.
    ProtoNeti Search...

    Publicationsi

    1. "Sub-Saharan African coding sequence variation and haplotype diversity at the NAT2 gene."
      Patin E., Harmant C., Quintana-Murci L.
      Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: AKELE2404-1Imported, AKELE2405-2Imported, AKELE2406-1Imported, AKELE2412-1Imported, AKELE2412-2Imported, AKELE2414-1Imported, AKELE2414-2Imported, AKELE2416-1Imported, AKELE2418-2Imported, BAKOLA280401-1Imported, BAKOLA400201-1Imported, BAKOLA400401-1Imported, BAKOLA801002-2Imported, BAKOLA880701-2Imported, BAKOLA940203-1Imported, BAKOLA950105-1Imported, BAKOLA950106-2Imported, BEDZAN01-1Imported, BEDZAN21-1Imported, BEDZAN24-1Imported, BEDZAN24-2Imported, BEDZAN29-2Imported, BEDZAN35-2Imported, BEDZAN50-1Imported, BIAKA0757-1Imported, BIAKA0764-1Imported, BIAKA0806-2Imported, BIAKA1700-2Imported, C.BAKA01-1Imported, C.BAKA03-1Imported, C.BAKA06-1Imported, C.BAKA07-2Imported, C.BAKA104-1Imported, C.BAKA104-2Imported, C.BAKA26-1Imported, C.BAKA59-1Imported, C.BAKA95-2Imported, C.BAKA98-1Imported, C.BAKA99-1Imported, CHAGGA4127-2Imported, CHAGGA4128-2Imported, CHAGGA4129-1Imported, CHAGGA4133-2Imported, CHAGGA4135-1Imported, CHAGGA4143-1Imported, CHAGGA4151-1Imported, CHAGGA4156-1Imported, G.BAKA0907-1Imported, G.BAKA0914-1Imported, G.BAKA0917-1Imported, G.BAKA0917-2Imported, G.BAKA0924-1Imported, G.BAKA0929-1Imported, MBUTI1037-1Imported, NGUMBA24-2Imported, NGUMBA45-2Imported, NGUMBA59-2Imported, NGUMBA60-1Imported, NGUMBA60-2Imported, NGUMBA64-1Imported, NGUMBA64-2Imported, SAN0987-1Imported, SAN0987-2Imported, SAN0988-1Imported, SAN0988-2Imported, SAN0992-2Imported, SAN1032-2Imported, SOMALI18-2Imported, YORUBA3846-1Imported, YORUBA3848-1Imported, YORUBA3848-2Imported, YORUBA3850-1Imported, YORUBA3850-2Imported, YORUBA3851-2Imported, YORUBA3858-1Imported, YORUBA3859-2Imported, YORUBA3860-2Imported, YORUBA3878-1Imported, YORUBA3879-1Imported, YORUBA3888-1Imported, YORUBA3889-1Imported, YORUBA3891-2Imported, YORUBA3892-1Imported and YORUBA3893-1Imported.
    2. "Worldwide distribution of NAT2 diversity: implications for NAT2 evolutionary history."
      Sabbagh A., Langaney A., Darlu P., Gerard N., Krishnamoorthy R., Poloni E.S.
      BMC Genet. 9:21-21(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MAN1_12A_1Imported, MAN1_12A_2Imported, MAN21_12AImported, MAN22_12AImported, MAN23_12AImported, MAN24_12AImported, MAN25_12AImported, MAN2_12A_1Imported, MAN2_12A_2Imported, MAN3_12AImported, MAN4_12AImported, MAN5_12AImported, MAN65_12AImported, MAN66_12AImported, MAN67_12AImported, MAN68_12AImported, MAN69_12AImported, MAN6_12AImported, MAN70_12AImported, MAN71_12AImported, MAN72_12AImported, MAN73_12AImported, MAN74_12AImported, MAN7_12AImported and MAN91_12AImported.

    Entry informationi

    Entry nameiA4Z6T7_HUMAN
    AccessioniPrimary (citable) accession number: A4Z6T7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 29, 2007
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.