A4Z217 (KHSE_BRASO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	BRADO6587

Organism

Bradyrhizobium sp. (strain ORS278) [Complete proteome] [HAMAP]

Taxonomic identifier

114615 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Bradyrhizobium

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 323	323	Homoserine kinase HAMAP MF_00301		PRO_0000300781

Sequences

	Sequence		Length	Mass (Da)
	A4Z217 [UniParc]. Last modified May 29, 2007. Version 1. Checksum: 32852EC32770C260	FASTA	323	35,355
	10 20 30 40 50 60 MAVYTDVAAD ELADFLKTYD IGELLSYKGI AEGVENSNFL LHTTKGSYIL TLYEKRVAVD 70 80 90 100 110 120 DLPYFLGLMA HLAERGVNCP QPARNRDGAV YSSLAGRPAA IINFLEGMWP RKPAVVHCAG 130 140 150 160 170 180 VGEALARMHL AGRDFPLVRK NPLSVSGWQS LFAQAADRAD TVQAGLSALL STELDYLARA 190 200 210 220 230 240 WPTDLPEGVI HADLFPDNVF FLGDHLSGLI DFPFSCNDIL AYDVAICLNA WCFEADHSLN 250 260 270 280 290 300 VTKARAFFNA YGRARPLSDA ELEALPLLAR GAAIRFLLTR LVDWLNVPAG ALVKPKDPLE 310 320 YVRKLRFHQA VTSARDYGIG ASA

References

[1]

"Legumes symbioses: absence of nod genes in photosynthetic bradyrhizobia." Giraud E., Moulin L., Vallenet D., Barbe V., Cytryn E., Avarre J.-C., Jaubert M., Simon D., Cartieaux F., Prin Y., Bena G., Hannibal L., Fardoux J., Kojadinovic M., Vuillet L., Lajus A., Cruveiller S., Rouy Z. , Mangenot S., Segurens B., Dossat C., Franck W.L., Chang W.-S., Saunders E., Bruce D., Richardson P., Normand P., Dreyfus B., Pignol D., Stacey G., Emerich D., Vermeglio A., Medigue C., Sadowsky M. Science 316:1307-1312(2007) [PubMed: 17540897] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ORS278.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU234118 Genomic DNA. Translation: CAL80193.1.
RefSeq	YP_001208408.1. NC_009445.1.
3D structure databases
ProteinModelPortal	A4Z217.
SMR	A4Z217. Positions 5-320.
ModBase	Search...
Protein-protein interaction databases
STRING	A4Z217.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5116999.
GenomeReviews	Gene locus BRADO6587 in contig CU234118_GR.
KEGG	bra:BRADO6587.
PATRIC	21229029. VBIBraSp122330_6302.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2334.
HOGENOM	HBG309377.
OMA	ICLNAWC.
ProtClustDB	PRK05231.
Enzyme and pathway databases
BioCyc	BSP376:BRADO6587-MONOMER.
Family and domain databases
HAMAP	MF_00301. Homoser_kinase_2. [Tree]
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR005280. Homoserine_kinase_ThrB. IPR011009. Kinase-like_dom. [Graphical view]
KO	K02204.
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR00938. ThrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_BRASO

Accession

Primary (citable) accession number: A4Z217

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	May 29, 2007
Last modified:	December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program