Reviewed, UniProtKB/Swiss-Prot A4Z1S4 (ARLY_BRASO)

Names and origin

Protein names

Recommended name:
    Argininosuccinate lyase
      Short name=ASAL
    EC=4.3.2.1
Alternative name(s):
    Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	BRADO6487

Organism

Bradyrhizobium sp. (strain ORS278) [Complete proteome] [HAMAP]

Taxonomic identifier

114615 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Bradyrhizobium

Protein attributes

Sequence length	463 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 463	463	Argininosuccinate lyase HAMAP MF_00006		PRO_1000000454

Sequences

	Sequence		Length	Mass (Da)
	A4Z1S4-1 [UniParc]. Last modified May 29, 2007. Version 1. Checksum: 13FC11A49E21B0AF	FASTA	463	50,215
	10 20 30 40 50 60 MSNKMWGGRF TERPDEIMED INVSIDVDRH LYAQDIAASK AHAAMLAAQG IITSGDAKNM 70 80 90 100 110 120 ARGLDTILSE ITKGSFEFKR ALEDIHMNVE SRLSELIGPA AGRLHTARSR NDQVATDFRL 130 140 150 160 170 180 FVRDEIDDID AALAAYQQAL ATRALEFAGT VMPGFTHLQT AQPVTFGHHL LAYVEMAGRD 190 200 210 220 230 240 RGRFADARER LNESPLGAAA LAGTSFPIDR HATAQALGFD RPMANSLDAV SDRDFVLETL 250 260 270 280 290 300 SAASICAVHL SRFAEEIVIW TSPLVGLIKL SDKFTTGSSI MPQKRNPDAA ELVRAKTGRV 310 320 330 340 350 360 IGALNGLLIV MKGLPLAYQK DMQEDKQGAM EAFAALSLAI RAMTGMALDL VPDEARMKAA 370 380 390 400 410 420 AGEGYATATD LADWLVRTLK MPFREAHHVT GRIVALASKQ GVALHELPLE AMQEVEPKIT 430 440 450 460 ADVLGVLSVE ASVKSRTSFG GTAPKNVASQ AKAWLKRLEK QRK

References

[1]

"Legumes symbioses: absence of nod genes in photosynthetic bradyrhizobia." Giraud E., Moulin L., Vallenet D., Barbe V., Cytryn E., Avarre J.-C., Jaubert M., Simon D., Cartieaux F., Prin Y., Bena G., Hannibal L., Fardoux J., Kojadinovic M., Vuillet L., Lajus A., Cruveiller S., Rouy Z. , Mangenot S., Segurens B., Dossat C., Franck W.L., Chang W.-S., Saunders E., Bruce D., Richardson P., Normand P., Dreyfus B., Pignol D., Stacey G., Emerich D., Vermeglio A., Medigue C., Sadowsky M. Science 316:1307-1312(2007) [PubMed: 17540897] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CU234118 Genomic DNA. Translation: CAL80100.1.
RefSeq	YP_001208315.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A4Z1S4.
Genome annotation databases
GeneID	5115772.
GenomeReviews	Gene locus BRADO6487 in contig CU234118_GR.
KEGG	bra:BRADO6487.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	MAEDLIF.
Family and domain databases
HAMAP	MF_00006. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. [Graphical view]
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
TIGRFAMs	TIGR00838. argH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_BRASO

Accession

Primary (citable) accession number: A4Z1S4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 29, 2007
Last modified:	November 3, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)