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Protein

Pyrroloquinoline-quinone synthase

Gene

pqqC

Organism
Bradyrhizobium sp. (strain ORS278)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ.UniRule annotation

Catalytic activityi

6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H2O2 + 2 H2O.UniRule annotation

Pathwayi: pyrroloquinoline quinone biosynthesis

This protein is involved in the pathway pyrroloquinoline quinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway pyrroloquinoline quinone biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

PQQ biosynthesis

Enzyme and pathway databases

BioCyciBSP114615:GJN5-5538-MONOMER.
UniPathwayiUPA00539.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrroloquinoline-quinone synthaseUniRule annotation (EC:1.3.3.11UniRule annotation)
Alternative name(s):
Coenzyme PQQ synthesis protein CUniRule annotation
Pyrroloquinoline quinone biosynthesis protein CUniRule annotation
Gene namesi
Name:pqqCUniRule annotation
Ordered Locus Names:BRADO5795
OrganismiBradyrhizobium sp. (strain ORS278)
Taxonomic identifieri114615 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
Proteomesi
  • UP000001994 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259Pyrroloquinoline-quinone synthasePRO_1000061667Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi114615.BRADO5795.

Structurei

3D structure databases

ProteinModelPortaliA4YZY5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PqqC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41086XE. Bacteria.
COG5424. LUCA.
HOGENOMiHOG000217947.
KOiK06137.
OMAiCNALIFK.
OrthoDBiEOG6JTC7S.

Family and domain databases

Gene3Di1.20.910.10. 1 hit.
HAMAPiMF_00654. PQQ_syn_PqqC.
InterProiIPR016084. Haem_Oase-like_multi-hlx.
IPR011845. PQQ_synth_PqqC.
IPR004305. Thiaminase-2/PQQC.
[Graphical view]
PfamiPF03070. TENA_THI-4. 1 hit.
[Graphical view]
SUPFAMiSSF48613. SSF48613. 1 hit.
TIGRFAMsiTIGR02111. PQQ_syn_pqqC. 1 hit.

Sequencei

Sequence statusi: Complete.

A4YZY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEVNLSGMT ALSIGRGVTL NNASELEAAL RHIGATRYHN HHPFHKLLHS
60 70 80 90 100
GKLNKGQVQA WALNRYYYQS TIPLKDAMVM TRFRDRATRL EWRHRIEDHD
110 120 130 140 150
GDVGTEGGIE RWIKLTEGLG LDTAYVESTE GILPATRFAV EAYVHFCRDR
160 170 180 190 200
SPLEAIASSL TELFAPSIHE ERISGMLEHY SFVNNDTMSY FKRRLTQAPR
210 220 230 240 250
DANFALHYVR EHATTPEQRA AVCNALIFKT NVLWVQLDAL YHAYVEGHIP

PGAFVPKEG
Length:259
Mass (Da):29,387
Last modified:May 29, 2007 - v1
Checksum:i33C9F7FC73999D48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU234118 Genomic DNA. Translation: CAL79461.1.
RefSeqiWP_012029364.1. NC_009445.1.

Genome annotation databases

EnsemblBacteriaiCAL79461; CAL79461; BRADO5795.
KEGGibra:BRADO5795.
PATRICi21227535. VBIBraSp122330_5564.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU234118 Genomic DNA. Translation: CAL79461.1.
RefSeqiWP_012029364.1. NC_009445.1.

3D structure databases

ProteinModelPortaliA4YZY5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi114615.BRADO5795.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL79461; CAL79461; BRADO5795.
KEGGibra:BRADO5795.
PATRICi21227535. VBIBraSp122330_5564.

Phylogenomic databases

eggNOGiENOG41086XE. Bacteria.
COG5424. LUCA.
HOGENOMiHOG000217947.
KOiK06137.
OMAiCNALIFK.
OrthoDBiEOG6JTC7S.

Enzyme and pathway databases

UniPathwayiUPA00539.
BioCyciBSP114615:GJN5-5538-MONOMER.

Family and domain databases

Gene3Di1.20.910.10. 1 hit.
HAMAPiMF_00654. PQQ_syn_PqqC.
InterProiIPR016084. Haem_Oase-like_multi-hlx.
IPR011845. PQQ_synth_PqqC.
IPR004305. Thiaminase-2/PQQC.
[Graphical view]
PfamiPF03070. TENA_THI-4. 1 hit.
[Graphical view]
SUPFAMiSSF48613. SSF48613. 1 hit.
TIGRFAMsiTIGR02111. PQQ_syn_pqqC. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ORS278.

Entry informationi

Entry nameiPQQC_BRASO
AccessioniPrimary (citable) accession number: A4YZY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 29, 2007
Last modified: November 11, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.