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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Bradyrhizobium sp. (strain ORS 278)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:BRADO5662
OrganismiBradyrhizobium sp. (strain ORS 278)
Taxonomic identifieri114615 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
Proteomesi
  • UP000001994 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei34 – 54HelicalUniRule annotationAdd BLAST21
Transmembranei79 – 99HelicalUniRule annotationAdd BLAST21
Transmembranei102 – 122HelicalUniRule annotationAdd BLAST21
Transmembranei140 – 160HelicalUniRule annotationAdd BLAST21
Transmembranei176 – 196HelicalUniRule annotationAdd BLAST21
Transmembranei207 – 227HelicalUniRule annotationAdd BLAST21
Transmembranei247 – 267HelicalUniRule annotationAdd BLAST21
Transmembranei271 – 291HelicalUniRule annotationAdd BLAST21
Transmembranei296 – 316HelicalUniRule annotationAdd BLAST21
Transmembranei345 – 365HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000029421 – 368Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST368

Interactioni

Protein-protein interaction databases

STRINGi114615.BRADO5662.

Structurei

3D structure databases

SMRiA4YZK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275122.
KOiK01000.
OMAiLMSPLHH.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A4YZK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFYWLIELTN TFPSLSVFRG VLNVFRYITF RTGGAVVTGA LFVFLFGPWI
60 70 80 90 100
IDHLRLRQGK GQPIRTDGPQ SHIISKKGTP TMGGLMILSG LVVSTVLWAN
110 120 130 140 150
PLNPYVWIVL AVTLGFGFVG FYDDYLKVTK QSHSGFAGRA RLLIEAAIAL
160 170 180 190 200
VACYALVRLG RDPSSTGLAI PFFKDLVIKF GWMYVIFGAF VIVGAGNAVN
210 220 230 240 250
LTDGLDGLAI VPVMIASASF GLIAYLAGNA VFSDYLQIHY VAGTGELAVL
260 270 280 290 300
CGAVLGAGLG FLWFNAPPAS IFMGDTGSLA LGGMLGSIAV AVKHEIVLAV
310 320 330 340 350
IGGLFVLEAV SVIVQVASFK LTGKRIFRMA PIHHHFEQLG WTEPQIVIRF
360
WIISVMLALV GLSTLKLR
Length:368
Mass (Da):39,628
Last modified:May 29, 2007 - v1
Checksum:iCA554B3EE5D0DB31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU234118 Genomic DNA. Translation: CAL79332.1.
RefSeqiWP_012029239.1. NC_009445.1.

Genome annotation databases

EnsemblBacteriaiCAL79332; CAL79332; BRADO5662.
KEGGibra:BRADO5662.

Similar proteinsi

Entry informationi

Entry nameiMRAY_BRASO
AccessioniPrimary (citable) accession number: A4YZK6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: August 30, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families