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A4YZK6 (MRAY_BRASO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:BRADO5662
OrganismBradyrhizobium sp. (strain ORS278) [Complete proteome] [HAMAP]
Taxonomic identifier114615 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Bradyrhizobium

Protein attributes

Sequence length368 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 368368Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038
PRO_1000002942

Regions

Transmembrane34 – 5421Helical; Potential
Transmembrane79 – 9921Helical; Potential
Transmembrane102 – 12221Helical; Potential
Transmembrane140 – 16021Helical; Potential
Transmembrane176 – 19621Helical; Potential
Transmembrane207 – 22721Helical; Potential
Transmembrane247 – 26721Helical; Potential
Transmembrane271 – 29121Helical; Potential
Transmembrane296 – 31621Helical; Potential
Transmembrane345 – 36521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A4YZK6 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: CA554B3EE5D0DB31

FASTA36839,628
        10         20         30         40         50         60 
MFYWLIELTN TFPSLSVFRG VLNVFRYITF RTGGAVVTGA LFVFLFGPWI IDHLRLRQGK 

        70         80         90        100        110        120 
GQPIRTDGPQ SHIISKKGTP TMGGLMILSG LVVSTVLWAN PLNPYVWIVL AVTLGFGFVG 

       130        140        150        160        170        180 
FYDDYLKVTK QSHSGFAGRA RLLIEAAIAL VACYALVRLG RDPSSTGLAI PFFKDLVIKF 

       190        200        210        220        230        240 
GWMYVIFGAF VIVGAGNAVN LTDGLDGLAI VPVMIASASF GLIAYLAGNA VFSDYLQIHY 

       250        260        270        280        290        300 
VAGTGELAVL CGAVLGAGLG FLWFNAPPAS IFMGDTGSLA LGGMLGSIAV AVKHEIVLAV 

       310        320        330        340        350        360 
IGGLFVLEAV SVIVQVASFK LTGKRIFRMA PIHHHFEQLG WTEPQIVIRF WIISVMLALV 


GLSTLKLR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU234118 Genomic DNA. Translation: CAL79332.1.
RefSeqYP_001207549.1. NC_009445.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA4YZK6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5115595.
GenomeReviewsGene locus BRADO5662 in contig CU234118_GR.
KEGGbra:BRADO5662.
PATRIC21227283. VBIBraSp122330_5438.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0472.
HOGENOMHBG708263.
OMARFWIISM.
ProtClustDBPRK00108.

Enzyme and pathway databases

BioCycBSP376:BRADO5662-MONOMER.

Family and domain databases

HAMAPMF_00038. MraY.
[Tree]
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
KOK01000.
PANTHERPTHR22926. Glyco_trans_4. 1 hit.
PTHR22926:SF3. PNAcPpept_trans. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. MraY. 1 hit.
PROSITEPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_BRASO
AccessionPrimary (citable) accession number: A4YZK6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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