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Protein

D-alanine--D-alanine ligase

Gene

ddlB

Organism
Bradyrhizobium sp. (strain ORS 278)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.SAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.SAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+SAAS annotation
  • Mn2+SAAS annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.SAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseSAAS annotationImported
Biological processCell cycle, Cell divisionImported, Cell shape, Cell wall biogenesis/degradationSAAS annotation, Peptidoglycan synthesisSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, MagnesiumSAAS annotation, ManganeseSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSP114615:G1GI7-5379-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseSAAS annotation (EC:6.3.2.4SAAS annotation)
Gene namesi
Name:ddlBImported
Ordered Locus Names:BRADO5656Imported
OrganismiBradyrhizobium sp. (strain ORS 278)Imported
Taxonomic identifieri114615 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
Proteomesi
  • UP000001994 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi114615.BRADO5656

Structurei

3D structure databases

ProteinModelPortaliA4YZK0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini128 – 321ATP-graspInterPro annotationAdd BLAST194

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.SAAS annotation

Phylogenomic databases

eggNOGiENOG4105CPF Bacteria
COG1181 LUCA
HOGENOMiHOG000011592
KOiK01921
OMAiMQGLLEC
OrthoDBiPOG091H00GT

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR011095 Dala_Dala_lig_C
IPR011127 Dala_Dala_lig_N
IPR016185 PreATP-grasp_dom_sf
PfamiView protein in Pfam
PF07478 Dala_Dala_lig_C, 1 hit
PF01820 Dala_Dala_lig_N, 1 hit
SUPFAMiSSF52440 SSF52440, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit

Sequencei

Sequence statusi: Complete.

A4YZK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTTILFGGS NKERLVSVAS AKALHAALPE ADLWFWEADD TVQQASGPAL
60 70 80 90 100
VAHAKPFEEP FTADGVRIGT LAEALDRARA EDRILVLGLH GGRAENGELQ
110 120 130 140 150
VMCEMRGVPF TGSSSAASHL AFDKVAAKRF AVLGGVTAAE GVALDNAETA
160 170 180 190 200
LARYGKLIAK PVKDGSSFGL IFVNAKQDLV AVKAAAATEE YLIEPFVTGK
210 220 230 240 250
EATCGVLEQA DGSLIALPPI EILPADGAFN YFAKYLAAAT KEICPGRFNP
260 270 280 290 300
EVTAALQREA IKAHRALSCG GYSRTDFIVS ADGPVYLETN TLPGLTAASL
310 320
YPKALAAQGI PFADFLQQQI ALAERRVRH
Length:329
Mass (Da):34,796
Last modified:May 29, 2007 - v1
Checksum:iD5388FBD6E0ABEE0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU234118 Genomic DNA Translation: CAL79326.1
RefSeqiWP_012029233.1, NC_009445.1

Genome annotation databases

EnsemblBacteriaiCAL79326; CAL79326; BRADO5656
KEGGibra:BRADO5656

Similar proteinsi

Entry informationi

Entry nameiA4YZK0_BRASO
AccessioniPrimary (citable) accession number: A4YZK0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 29, 2007
Last sequence update: May 29, 2007
Last modified: March 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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