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A4YZA6 (ILVC_BRASO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ketol-acid reductoisomerase
EC=1.1.1.86
Alternative name(s):
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacil reductoisomerase
Gene names
Name:ilvC
Ordered Locus Names:BRADO5559
OrganismBradyrhizobium sp. (strain ORS278) [Complete proteome] [HAMAP]
Taxonomic identifier114615 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Bradyrhizobium

Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP MF_00435

(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP MF_00435

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP MF_00435

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP MF_00435

Sequence similarities

Belongs to the ketol-acid reductoisomerase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 339339Ketol-acid reductoisomerase HAMAP MF_00435
PRO_1000050482

Sites

Active site1081 Potential

Sequences

Sequence LengthMass (Da)Tools
A4YZA6 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: 876F1D01315F21C9

FASTA33937,046
        10         20         30         40         50         60 
MRVYYDRDAD LNLIKGKKVV IVGYGSQGHA HALNLKDSGV KDVAIALRKG SASAKKAEGA 

        70         80         90        100        110        120 
GFKVMEVAEA AKWADLVMML TPDELQGDIY REHLHDNMKQ GAALVFAHGL NVHFNLLDPR 

       130        140        150        160        170        180 
ADLDVLMIAP KGPGHTVRSE YQRGGGVPCL IAIAKDSSGN AHDLGLSYAS AIGGGRAGII 

       190        200        210        220        230        240 
ETTFKEECET DLFGEQAVLC GGLVELIKAG YETLTEAGYA PEMAYFECLH EVKLIVDLIY 

       250        260        270        280        290        300 
EGGIANMNYS ISNTAEYGEY VTGPRIITPE TKAEMKRVLD DIQSGRFARD WMLENKVNQS 

       310        320        330 
SFKATRARLS QHPIEEVGAR LRDMMPWIKK GALVDKSKN

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU234118 Genomic DNA. Translation: CAL79232.1.
RefSeqYP_001207449.1. NC_009445.1.

3D structure databases

ProteinModelPortalA4YZA6.
SMRA4YZA6. Positions 1-328.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4YZA6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5119448.
GenomeReviewsGene locus BRADO5559 in contig CU234118_GR.
KEGGbra:BRADO5559.
PATRIC21227079. VBIBraSp122330_5336.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0059.
HOGENOMHBG286525.
OMAMAYAKGI.
ProtClustDBPRK05479.

Enzyme and pathway databases

BioCycBSP376:BRADO5559-MONOMER.

Family and domain databases

HAMAPMF_00435. IlvC.
[Tree]
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
[Graphical view]
Gene3DG3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00053.
PANTHERPTHR21371. AcH_isomrdctse. 1 hit.
PfamPF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view]
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00465. IlvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameILVC_BRASO
AccessionPrimary (citable) accession number: A4YZA6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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