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A4YXQ9

- GCSP_BRASO

UniProt

A4YXQ9 - GCSP_BRASO

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, BRADO4984
Organism
Bradyrhizobium sp. (strain ORS278)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBSP114615:GJN5-4759-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:BRADO4984
OrganismiBradyrhizobium sp. (strain ORS278)
Taxonomic identifieri114615 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
ProteomesiUP000001994: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 957957Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_1000062073Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei702 – 7021N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi114615.BRADO4984.

Structurei

3D structure databases

ProteinModelPortaliA4YXQ9.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A4YXQ9-1 [UniParc]FASTAAdd to Basket

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MTTPLKPLDD AATSFARRHI GPSPRDVAAM LETVNAKSVA ELMAQTLPGT    50
IRQAAPLDIG PALSETEALS HMRALAAQNQ VFTSLIGQGY AGTIMPAVIQ 100
RNILENPAWY TAYTPYQPEI SQGRLEALFN FQTMICDLTG LDVANASLLD 150
EGTAAAEAMA LAERSARAKT KAFFVDHNVH PQTLTVLRTR AEPLGWKLIV 200
GDPAGDLDGA EVFGGLLQYP DTTGALRDPR AAIAKLHDKG ALAILAADLL 250
ALTLIASPGE LGADIAIGSA QRFGVPMGYG GPHAAYMAVR DALKRSLPGR 300
IVGLSVDSRG APAYRLALQT REQHIRREKA TSNICTAQVL LAVIAAMYAV 350
YHGPAGLKAI ARTVHRRTAV LAAGLRKLGF APANDAFFDT VTVEAGANAS 400
SIIARAEAER INLGHNGSRL RIALDETTTA DVVEAAWRAF GGELSYADIE 450
AEARDAVPAE LKRQRPYLTH PVFHAHRSET EMLRYLRKLA DRDLALDRAM 500
IPLGSCTMKL NATTEMIPLT WPEFSSLHPF VPRAQAAGYH AMFADLQDWL 550
CRISGYDAVS LQPNSGAQGE YAGLLAIRGY HAARGEAHRT ICLIPSSAHG 600
TNPASAHMVG MEVVVVGCDA GGNVDLADLK AKAEAHSQKL AAIMITYPST 650
HGVFEEHIRD ICDIVHAHGG QVYLDGANLN AQVGLARPGD YGADVSHFNL 700
HKTFCIPHGG GGPGMGPIGV KAHLAPFLPG HPATDGKTAH PVGPVSAAPY 750
GSASILTISY IYMLLMGGEG LTRATEIAIL NANYVAARLD AHFPVLYRNE 800
RGRIAHECII DPRLLKQTSG VTVDDIAKRL IDYGFHAPTM SFPVAGTLMI 850
EPTESESKAE LDRFCDAMIA IRKEIAEVEQ GRFTIEASPL RHAPHTVHDI 900
ADDEWSRAYR RSEGCFPAGS SRTDKYWCPV GRVDNVYGDR NLVCSCPPVE 950
DYAQAAE 957
Length:957
Mass (Da):102,667
Last modified:May 29, 2007 - v1
Checksum:iB875D6C70B7C1F3A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU234118 Genomic DNA. Translation: CAL78685.1.
RefSeqiWP_012028626.1. NC_009445.1.
YP_001206902.1. NC_009445.1.

Genome annotation databases

EnsemblBacteriaiCAL78685; CAL78685; BRADO4984.
GeneIDi5120973.
KEGGibra:BRADO4984.
PATRICi21225981. VBIBraSp122330_4788.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU234118 Genomic DNA. Translation: CAL78685.1 .
RefSeqi WP_012028626.1. NC_009445.1.
YP_001206902.1. NC_009445.1.

3D structure databases

ProteinModelPortali A4YXQ9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 114615.BRADO4984.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL78685 ; CAL78685 ; BRADO4984 .
GeneIDi 5120973.
KEGGi bra:BRADO4984.
PATRICi 21225981. VBIBraSp122330_4788.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci BSP114615:GJN5-4759-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ORS278.

Entry informationi

Entry nameiGCSP_BRASO
AccessioniPrimary (citable) accession number: A4YXQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 29, 2007
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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