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A4YXQ9 (GCSP_BRASO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:BRADO4984
OrganismBradyrhizobium sp. (strain ORS278) [Complete proteome] [HAMAP]
Taxonomic identifier114615 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium

Protein attributes

Sequence length957 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 957957Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000062073

Amino acid modifications

Modified residue7021N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A4YXQ9 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: B875D6C70B7C1F3A

FASTA957102,667
        10         20         30         40         50         60 
MTTPLKPLDD AATSFARRHI GPSPRDVAAM LETVNAKSVA ELMAQTLPGT IRQAAPLDIG 

        70         80         90        100        110        120 
PALSETEALS HMRALAAQNQ VFTSLIGQGY AGTIMPAVIQ RNILENPAWY TAYTPYQPEI 

       130        140        150        160        170        180 
SQGRLEALFN FQTMICDLTG LDVANASLLD EGTAAAEAMA LAERSARAKT KAFFVDHNVH 

       190        200        210        220        230        240 
PQTLTVLRTR AEPLGWKLIV GDPAGDLDGA EVFGGLLQYP DTTGALRDPR AAIAKLHDKG 

       250        260        270        280        290        300 
ALAILAADLL ALTLIASPGE LGADIAIGSA QRFGVPMGYG GPHAAYMAVR DALKRSLPGR 

       310        320        330        340        350        360 
IVGLSVDSRG APAYRLALQT REQHIRREKA TSNICTAQVL LAVIAAMYAV YHGPAGLKAI 

       370        380        390        400        410        420 
ARTVHRRTAV LAAGLRKLGF APANDAFFDT VTVEAGANAS SIIARAEAER INLGHNGSRL 

       430        440        450        460        470        480 
RIALDETTTA DVVEAAWRAF GGELSYADIE AEARDAVPAE LKRQRPYLTH PVFHAHRSET 

       490        500        510        520        530        540 
EMLRYLRKLA DRDLALDRAM IPLGSCTMKL NATTEMIPLT WPEFSSLHPF VPRAQAAGYH 

       550        560        570        580        590        600 
AMFADLQDWL CRISGYDAVS LQPNSGAQGE YAGLLAIRGY HAARGEAHRT ICLIPSSAHG 

       610        620        630        640        650        660 
TNPASAHMVG MEVVVVGCDA GGNVDLADLK AKAEAHSQKL AAIMITYPST HGVFEEHIRD 

       670        680        690        700        710        720 
ICDIVHAHGG QVYLDGANLN AQVGLARPGD YGADVSHFNL HKTFCIPHGG GGPGMGPIGV 

       730        740        750        760        770        780 
KAHLAPFLPG HPATDGKTAH PVGPVSAAPY GSASILTISY IYMLLMGGEG LTRATEIAIL 

       790        800        810        820        830        840 
NANYVAARLD AHFPVLYRNE RGRIAHECII DPRLLKQTSG VTVDDIAKRL IDYGFHAPTM 

       850        860        870        880        890        900 
SFPVAGTLMI EPTESESKAE LDRFCDAMIA IRKEIAEVEQ GRFTIEASPL RHAPHTVHDI 

       910        920        930        940        950 
ADDEWSRAYR RSEGCFPAGS SRTDKYWCPV GRVDNVYGDR NLVCSCPPVE DYAQAAE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU234118 Genomic DNA. Translation: CAL78685.1.
RefSeqYP_001206902.1. NC_009445.1.

3D structure databases

ProteinModelPortalA4YXQ9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING114615.BRADO4984.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAL78685; CAL78685; BRADO4984.
GeneID5120973.
KEGGbra:BRADO4984.
PATRIC21225981. VBIBraSp122330_4788.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycBSP114615:GJN5-4759-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_BRASO
AccessionPrimary (citable) accession number: A4YXQ9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 29, 2007
Last modified: February 19, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families