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A4YXQ9

- GCSP_BRASO

UniProt

A4YXQ9 - GCSP_BRASO

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Bradyrhizobium sp. (strain ORS278)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (29 May 2007)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciBSP114615:GJN5-4759-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:BRADO4984
    OrganismiBradyrhizobium sp. (strain ORS278)
    Taxonomic identifieri114615 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
    ProteomesiUP000001994: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 957957Glycine dehydrogenase (decarboxylating)PRO_1000062073Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei702 – 7021N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi114615.BRADO4984.

    Structurei

    3D structure databases

    ProteinModelPortaliA4YXQ9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4YXQ9-1 [UniParc]FASTAAdd to Basket

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    MTTPLKPLDD AATSFARRHI GPSPRDVAAM LETVNAKSVA ELMAQTLPGT    50
    IRQAAPLDIG PALSETEALS HMRALAAQNQ VFTSLIGQGY AGTIMPAVIQ 100
    RNILENPAWY TAYTPYQPEI SQGRLEALFN FQTMICDLTG LDVANASLLD 150
    EGTAAAEAMA LAERSARAKT KAFFVDHNVH PQTLTVLRTR AEPLGWKLIV 200
    GDPAGDLDGA EVFGGLLQYP DTTGALRDPR AAIAKLHDKG ALAILAADLL 250
    ALTLIASPGE LGADIAIGSA QRFGVPMGYG GPHAAYMAVR DALKRSLPGR 300
    IVGLSVDSRG APAYRLALQT REQHIRREKA TSNICTAQVL LAVIAAMYAV 350
    YHGPAGLKAI ARTVHRRTAV LAAGLRKLGF APANDAFFDT VTVEAGANAS 400
    SIIARAEAER INLGHNGSRL RIALDETTTA DVVEAAWRAF GGELSYADIE 450
    AEARDAVPAE LKRQRPYLTH PVFHAHRSET EMLRYLRKLA DRDLALDRAM 500
    IPLGSCTMKL NATTEMIPLT WPEFSSLHPF VPRAQAAGYH AMFADLQDWL 550
    CRISGYDAVS LQPNSGAQGE YAGLLAIRGY HAARGEAHRT ICLIPSSAHG 600
    TNPASAHMVG MEVVVVGCDA GGNVDLADLK AKAEAHSQKL AAIMITYPST 650
    HGVFEEHIRD ICDIVHAHGG QVYLDGANLN AQVGLARPGD YGADVSHFNL 700
    HKTFCIPHGG GGPGMGPIGV KAHLAPFLPG HPATDGKTAH PVGPVSAAPY 750
    GSASILTISY IYMLLMGGEG LTRATEIAIL NANYVAARLD AHFPVLYRNE 800
    RGRIAHECII DPRLLKQTSG VTVDDIAKRL IDYGFHAPTM SFPVAGTLMI 850
    EPTESESKAE LDRFCDAMIA IRKEIAEVEQ GRFTIEASPL RHAPHTVHDI 900
    ADDEWSRAYR RSEGCFPAGS SRTDKYWCPV GRVDNVYGDR NLVCSCPPVE 950
    DYAQAAE 957
    Length:957
    Mass (Da):102,667
    Last modified:May 29, 2007 - v1
    Checksum:iB875D6C70B7C1F3A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU234118 Genomic DNA. Translation: CAL78685.1.
    RefSeqiWP_012028626.1. NC_009445.1.
    YP_001206902.1. NC_009445.1.

    Genome annotation databases

    EnsemblBacteriaiCAL78685; CAL78685; BRADO4984.
    GeneIDi5120973.
    KEGGibra:BRADO4984.
    PATRICi21225981. VBIBraSp122330_4788.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU234118 Genomic DNA. Translation: CAL78685.1 .
    RefSeqi WP_012028626.1. NC_009445.1.
    YP_001206902.1. NC_009445.1.

    3D structure databases

    ProteinModelPortali A4YXQ9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 114615.BRADO4984.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAL78685 ; CAL78685 ; BRADO4984 .
    GeneIDi 5120973.
    KEGGi bra:BRADO4984.
    PATRICi 21225981. VBIBraSp122330_4788.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci BSP114615:GJN5-4759-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ORS278.

    Entry informationi

    Entry nameiGCSP_BRASO
    AccessioniPrimary (citable) accession number: A4YXQ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3