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A4YTA2

- NDK_BRASO

UniProt

A4YTA2 - NDK_BRASO

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Protein
Nucleoside diphosphate kinase
Gene
ndk, BRADO3334
Organism
Bradyrhizobium sp. (strain ORS278)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate By similarity.UniRule annotation

Catalytic activityi

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111ATP By similarity
Binding sitei59 – 591ATP By similarity
Binding sitei87 – 871ATP By similarity
Binding sitei93 – 931ATP By similarity
Binding sitei104 – 1041ATP By similarity
Binding sitei114 – 1141ATP By similarity
Active sitei117 – 1171Pros-phosphohistidine intermediate By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW
  3. nucleoside diphosphate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. CTP biosynthetic process Source: UniProtKB-HAMAP
  2. GTP biosynthetic process Source: UniProtKB-HAMAP
  3. UTP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSP114615:GJN5-3180-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate kinase (EC:2.7.4.6)
Short name:
NDK
Short name:
NDP kinase
Alternative name(s):
Nucleoside-2-P kinase
Gene namesi
Name:ndk
Ordered Locus Names:BRADO3334
OrganismiBradyrhizobium sp. (strain ORS278)
Taxonomic identifieri114615 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
ProteomesiUP000001994: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 140140Nucleoside diphosphate kinaseUniRule annotation
PRO_1000026210Add
BLAST

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi114615.BRADO3334.

Structurei

3D structure databases

ProteinModelPortaliA4YTA2.
SMRiA4YTA2. Positions 2-138.

Family & Domainsi

Sequence similaritiesi

Belongs to the NDK family.

Phylogenomic databases

eggNOGiCOG0105.
HOGENOMiHOG000224565.
KOiK00940.
OMAiFTEDEIC.
OrthoDBiEOG67DPRV.

Family and domain databases

Gene3Di3.30.70.141. 1 hit.
HAMAPiMF_00451. NDP_kinase.
InterProiIPR001564. Nucleoside_diP_kinase.
IPR023005. Nucleoside_diP_kinase_AS.
[Graphical view]
PfamiPF00334. NDK. 1 hit.
[Graphical view]
PRINTSiPR01243. NUCDPKINASE.
SMARTiSM00562. NDK. 1 hit.
[Graphical view]
SUPFAMiSSF54919. SSF54919. 1 hit.
PROSITEiPS00469. NDP_KINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4YTA2-1 [UniParc]FASTAAdd to Basket

« Hide

MAIERTFSII KPDATERNLT GAINALIEKA GLRIVAQKRI RMTRDQAETF    50
YAVHKARPFF GELVDFMISG PVVVQVLEGE GAILKYRDVM GATDPSKAAE 100
GTIRKAHAKS IGENSVHGSD APETAAIEIA QFFAGNEIVG 140
Length:140
Mass (Da):15,128
Last modified:May 29, 2007 - v1
Checksum:i360B18D11B56DC94
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU234118 Genomic DNA. Translation: CAL77128.1.
RefSeqiWP_011926284.1. NC_009445.1.
YP_001205359.1. NC_009445.1.

Genome annotation databases

EnsemblBacteriaiCAL77128; CAL77128; BRADO3334.
GeneIDi5118522.
KEGGibra:BRADO3334.
PATRICi21222835. VBIBraSp122330_3233.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU234118 Genomic DNA. Translation: CAL77128.1 .
RefSeqi WP_011926284.1. NC_009445.1.
YP_001205359.1. NC_009445.1.

3D structure databases

ProteinModelPortali A4YTA2.
SMRi A4YTA2. Positions 2-138.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 114615.BRADO3334.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL77128 ; CAL77128 ; BRADO3334 .
GeneIDi 5118522.
KEGGi bra:BRADO3334.
PATRICi 21222835. VBIBraSp122330_3233.

Phylogenomic databases

eggNOGi COG0105.
HOGENOMi HOG000224565.
KOi K00940.
OMAi FTEDEIC.
OrthoDBi EOG67DPRV.

Enzyme and pathway databases

BioCyci BSP114615:GJN5-3180-MONOMER.

Family and domain databases

Gene3Di 3.30.70.141. 1 hit.
HAMAPi MF_00451. NDP_kinase.
InterProi IPR001564. Nucleoside_diP_kinase.
IPR023005. Nucleoside_diP_kinase_AS.
[Graphical view ]
Pfami PF00334. NDK. 1 hit.
[Graphical view ]
PRINTSi PR01243. NUCDPKINASE.
SMARTi SM00562. NDK. 1 hit.
[Graphical view ]
SUPFAMi SSF54919. SSF54919. 1 hit.
PROSITEi PS00469. NDP_KINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ORS278.

Entry informationi

Entry nameiNDK_BRASO
AccessioniPrimary (citable) accession number: A4YTA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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