ID   DNAE2_BRASO             Reviewed;        1170 AA.
AC   A4YRD9;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   16-JUN-2009, entry version 14.
DE   RecName: Full=Error-prone DNA polymerase;
DE            EC=2.7.7.7;
GN   Name=dnaE2; OrderedLocusNames=BRADO2647;
OS   Bradyrhizobium sp. (strain ORS278).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Bradyrhizobiaceae; Bradyrhizobium.
OX   NCBI_TaxID=114615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17540897; DOI=10.1126/science.1139548;
RA   Giraud E., Moulin L., Vallenet D., Barbe V., Cytryn E., Avarre J.-C.,
RA   Jaubert M., Simon D., Cartieaux F., Prin Y., Bena G., Hannibal L.,
RA   Fardoux J., Kojadinovic M., Vuillet L., Lajus A., Cruveiller S.,
RA   Rouy Z., Mangenot S., Segurens B., Dossat C., Franck W.L.,
RA   Chang W.-S., Saunders E., Bruce D., Richardson P., Normand P.,
RA   Dreyfus B., Pignol D., Stacey G., Emerich D., Vermeglio A.,
RA   Medigue C., Sadowsky M.;
RT   "Legumes symbioses: absence of nod genes in photosynthetic
RT   bradyrhizobia.";
RL   Science 316:1307-1312(2007).
CC   -!- FUNCTION: DNA polymerase involved in damage-induced mutagenesis
CC       and translesion synthesis (TLS). It is not the major replicative
CC       DNA polymerase (By similarity).
CC   -!- CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) =
CC       diphosphate + DNA(n+1).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Probable).
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2
CC       subfamily.
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DR   EMBL; CU234118; CAL76465.1; -; Genomic_DNA.
DR   RefSeq; YP_001204702.1; -.
DR   GeneID; 5120654; -.
DR   GenomeReviews; CU234118_GR; BRADO2647.
DR   KEGG; bra:BRADO2647; -.
DR   OMA; A4YRD9; LATNRNG.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:HAMAP.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0045020; P:error-prone DNA repair; IEA:HAMAP.
DR   HAMAP; MF_01902; -; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR004365; NA_bd_OB_tRNA-helicase.
DR   InterPro; IPR004013; PHP_C.
DR   InterPro; IPR003141; PHP_N.
DR   InterPro; IPR004805; PolC_alpha.
DR   Gene3D; G3DSA:2.40.50.140; OB_NA_bd_sub; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF02811; PHP; 1.
DR   Pfam; PF01336; tRNA_anti; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   TIGRFAMs; TIGR00594; polc; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; DNA damage; DNA repair; DNA replication;
KW   DNA-directed DNA polymerase; Nucleotidyltransferase; Transferase.
FT   CHAIN         1   1170       Error-prone DNA polymerase.
FT                                /FTId=PRO_1000070589.
SQ   SEQUENCE   1170 AA;  131983 MW;  73C24A0B6EA41E32 CRC64;
     MTPIPYAEIG VTTNFSFLHG GSHPQAYVHQ AAEYGLTAIG IADHNTLAGI VRAYSELSND
     QLGYRPKLLY GARLVFTCGT PDILVYPRDR AAYGRLCQLL TRGKRGSDLD KVAKGDCRLA
     FEDLFDFIAG QLLVLMPPHR FDEDALGAIL ARLKDSPAEG VWLAGSLLYR GDDRRRLARL
     ARLAASAKVP LIATNDVLYH HPQQRMLQDV LTCIREKASI ESIGRRLQAN AERHLKPGHE
     MARLFRDHPE AIAETLRFTD RIVFSLDQLK YQYPDEPVPP GKTAQGHLED LTWAGAKTYF
     GDKLDDRLRA VLNKELALIA ELNYAHYFLT VHDIVRYARS EGILCQGRGS AANSAVCYVL
     GITSVDPTKI DLLFERFISK ERLEPPDIDV DFEHSRREEV MQYVYHRYGR HRAAIIATVI
     HYRPRSAIRD VGKALGLTED VTSVLADTVW GSWGDGLSDM QVRQAGLDPH NPMIRRAVEL
     ASELITFPRH LSQHVGGYVL TQDRLDSYVP IGNAAMDDRT FIEWDKDDVD ALSMMKVDVL
     ALGMLTCIRK SFDLIADHKG RRYVLSDIKS EDDNEVYQML QRGESLGVFQ VESRAQMNML
     PRLKPRTFYD LVIEVAIVRP GPIQGDMVHP YLRRRNKLEK VTYPSPSPDH GPSDELYKVL
     HKTLGVPLFQ EQAMRIAIEA AKFSPEEANG LRRAMATFRN VGTIGSYEEK MVSNMIARGY
     DPAFAKSCFD QIKGFGSYGF PESHAASFAQ LVYVSSWLKY FHPDAFCCAL LNSQPMGFYA
     PAQIVGDARK NGVEIRDIDV SHSFADNTLE KTDGEYCAVR LGFRQIDGFR WIDRDEERIR
     KLSEAVRKEA LSVSTRSLPA ISPVSFRGAR SANPESRDSG FALRAPRNDN DRQIPLHNDD
     REDDWADRII RARQRRPFTS LEDFARDTAL PKRALLLLAD ADAFRSLGLD RRAALWAVRR
     LPDDVPLPLF EAAIAREQPD EGAQPLPEMP LPEHVVADYQ TIRLSLKGHP MEFLRRRFAA
     EGVLACRDVN DTNDRRRIRC AGVVLVRQRP GSAKGVVFMT LEDETGIANI VVWPKVMETF
     RKEVMGARLV LVEGRIQSSP EKVVHLVAER LVDRTADLTL LSDDRLDAIP HGATPAEPLN
     DDRRDHTDNP SQRVSHPRNV RILPRSRDFH
//