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A4YPK8 (A4YPK8_BRASO) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Coproporphyrinogen-III oxidase, aerobic HAMAP MF_00333
Short name=Coprogen oxidase HAMAP MF_00333
Short name=Coproporphyrinogenase HAMAP MF_00333
EC=1.3.3.3 HAMAP MF_00333
Gene names
Name:hemF HAMAP MF_00333 EMBL CAL75834.1
Ordered Locus Names:BRADO1972
OrganismBradyrhizobium sp. (strain ORS278) [Complete proteome] [HAMAP]
Taxonomic identifier114615 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Bradyrhizobium

Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III By similarity. HAMAP MF_00333 SAAS SAAS018375

Catalytic activity

Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O. HAMAP MF_00333 SAAS SAAS018375

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1. HAMAP MF_00333 SAAS SAAS018375

Subunit structure

Homodimer By similarity. HAMAP MF_00333 SAAS SAAS018375

Subcellular location

Cytoplasm By similarity HAMAP MF_00333.

Sequence similarities

Belongs to the aerobic coproporphyrinogen-III oxidase family. HAMAP MF_00333

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region68 – 7710Important for dimerization By similarity HAMAP MF_00333
Region128 – 1303Substrate binding By similarity HAMAP MF_00333
Region260 – 29536Important for dimerization By similarity HAMAP MF_00333
Region278 – 2836Substrate binding By similarity HAMAP MF_00333

Sites

Active site1261Proton donor By similarity HAMAP MF_00333
Binding site1121Substrate By similarity HAMAP MF_00333
Site1951Important for dimerization By similarity HAMAP MF_00333

Sequences

Sequence LengthMass (Da)Tools
A4YPK8 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: E0A1834F8C95E7F3

FASTA29533,356
        10         20         30         40         50         60 
MTTAAIEDRK ARARAWFESL RDQICAAFER LEEEAPADLY PRASAHFVRT PWERTDHGGG 

        70         80         90        100        110        120 
HGGGGVMSMM HGRLFEKVGV HCSTVHGEFA PEFRSQIPGA SEDPRFWASG ISLIAHLWSP 

       130        140        150        160        170        180 
HVPAVHMNTR FVVTTKSWFG GGADLTPVLD RRRNQEDPDT VAFHAAMKGA CDAHAAVASY 

       190        200        210        220        230        240 
DKYKRWCDEY FYLPHRKEPR GIGGIFYDHH DSGNWDADLA FTQDVGRAFL KVYPDLVRRN 

       250        260        270        280        290 
FSAPWTEADR EEQLIRRGRY VEFNLLYDRG TTFGLKTGGN VDSILSSMPP EVKWP

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU234118 Genomic DNA. Translation: CAL75834.1.
RefSeqYP_001204071.1. NC_009445.1.

3D structure databases

ProteinModelPortalA4YPK8.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4YPK8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5116316.
GenomeReviewsGene locus BRADO1972 in contig CU234118_GR.
KEGGbra:BRADO1972.
PATRIC21220161. VBIBraSp122330_1905.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0408.
HOGENOMHBG631180.
OMAVKAYLLD.
ProtClustDBPRK05330.

Family and domain databases

HAMAPMF_00333. Coprogen_oxidas.
[Tree]
InterProIPR001260. Coprogen_oxidase_aer.
IPR018375. Coprogen_oxidase_CS.
[Graphical view]
Gene3DG3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.
KOK00228.
PANTHERPTHR10755. Coprogen_oxidas. 1 hit.
PfamPF01218. Coprogen_oxidas. 1 hit.
[Graphical view]
PIRSFPIRSF000166. Coproporphyri_ox. 1 hit.
PRINTSPR00073. COPRGNOXDASE.
SUPFAMSSF102886. Coprogen_oxidas. 1 hit.
PROSITEPS01021. COPROGEN_OXIDASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA4YPK8_BRASO
AccessionPrimary (citable) accession number: A4YPK8
Entry history
Integrated into UniProtKB/TrEMBL: May 29, 2007
Last sequence update: May 29, 2007
Last modified: December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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