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Protein

Catalase-peroxidase

Gene

katG

Organism
Bradyrhizobium sp. (strain ORS 278)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei87Transition state stabilizerUniRule annotation1
Active sitei91Proton acceptorUniRule annotation1
Metal bindingi254Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:BRADO1666
OrganismiBradyrhizobium sp. (strain ORS 278)
Taxonomic identifieri114615 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
Proteomesi
  • UP000001994 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003547291 – 726Catalase-peroxidaseAdd BLAST726

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki90 ↔ 213Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-239)UniRule annotation
Cross-linki213 ↔ 239Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-90)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiA4YNR8.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi114615.BRADO1666.

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiYGATTMG.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4YNR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDVSKCPFS GGLKGFKNKD WWPNQLDLSV LHQHSNLSDP LGEAFDYAKE
60 70 80 90 100
FKSLDLDALV KDLHALMTDS QEWWPADFGH YGPLFIRMAW HAAGTYRIGD
110 120 130 140 150
GRGGAGTGQQ RFAPLNSWPD NANLDKARRL LWPIKQKYGQ KISWADLFVL
160 170 180 190 200
TGNVALESMG FKTFGFGGGR ADTWEPEQDI YWGPEGKWLA DERYSGDREL
210 220 230 240 250
AGSLAAVQMG LIYVNPEGPN GKPDPAAAAR DIRETFARMA MNDEETVALI
260 270 280 290 300
AGGHTFGKTH GAGDASLVGV EPEGADIAQQ GLGWASKYAS GKAGDTITSG
310 320 330 340 350
LEVIWTTTPT KWSNNYFENL FNYEWELTKS PAGAHQWTPK GGAGAGTVPD
360 370 380 390 400
AHDPSKRHAP SMLTTDIALR VDPAYEKISR RFLEHPDQFA DAFARAWFKL
410 420 430 440 450
THRDMGPKAR YLGPLVPKEE LIWQDPVPAL DHPVVDDKDV AALKAKILAA
460 470 480 490 500
GLSVSQLVST AWASASTFRG SDKRGGANGA RIRLAPQKDW AINNPAELSK
510 520 530 540 550
VLAKLEGIQK EFNGSATGGK KVSLADLIVL AGNAGVEAAA KKAGVEVTVP
560 570 580 590 600
FAPGRTDASQ EQTDVESFAV LEPTHDGFRN YLSGKQWLSG EELLVDKAQL
610 620 630 640 650
LTLTAPETTV LVGGLRVLGA NAAGSKHGVF TTQPEVLSND FFVNLLDMGI
660 670 680 690 700
AWTPVDQGEH TFEGRDRKSG AVKWTATRAD LIFGSHSQLR ALAEVYASSD
710 720
AKQKFVKDFV AAWTKVMNLD RFELKA
Length:726
Mass (Da):78,950
Last modified:May 29, 2007 - v1
Checksum:i3FF741C9ADD72A16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU234118 Genomic DNA. Translation: CAL75544.1.
RefSeqiWP_011924772.1. NC_009445.1.

Genome annotation databases

EnsemblBacteriaiCAL75544; CAL75544; BRADO1666.
KEGGibra:BRADO1666.
PATRICi21219557. VBIBraSp122330_1603.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU234118 Genomic DNA. Translation: CAL75544.1.
RefSeqiWP_011924772.1. NC_009445.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi114615.BRADO1666.

Proteomic databases

PRIDEiA4YNR8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL75544; CAL75544; BRADO1666.
KEGGibra:BRADO1666.
PATRICi21219557. VBIBraSp122330_1603.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiYGATTMG.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_BRASO
AccessioniPrimary (citable) accession number: A4YNR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: May 29, 2007
Last modified: November 2, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.