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Protein

Holliday junction ATP-dependent DNA helicase RuvA

Gene

ruvA

Organism
Bradyrhizobium sp. (strain ORS 278)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Helicase, Hydrolase
Biological processDNA damage, DNA recombination, DNA repair, SOS response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSP114615:G1GI7-1098-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Holliday junction ATP-dependent DNA helicase RuvAUniRule annotation (EC:3.6.4.12UniRule annotation)
Gene namesi
Name:ruvAUniRule annotation
Ordered Locus Names:BRADO1145
OrganismiBradyrhizobium sp. (strain ORS 278)
Taxonomic identifieri114615 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
Proteomesi
  • UP000001994 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000024051 – 205Holliday junction ATP-dependent DNA helicase RuvAAdd BLAST205

Proteomic databases

PRIDEiA4YMC6

Interactioni

Subunit structurei

Forms a complex with RuvB.UniRule annotation

Protein-protein interaction databases

STRINGi114615.BRADO1145

Structurei

3D structure databases

ProteinModelPortaliA4YMC6
SMRiA4YMC6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105KA4 Bacteria
COG0632 LUCA
HOGENOMiHOG000057115
KOiK03550
OMAiDCHGVGY
OrthoDBiPOG091H02EF

Family and domain databases

HAMAPiMF_00031 DNA_helic_RuvA, 1 hit
InterProiView protein in InterPro
IPR013849 DNA_helicase_Holl-junc_RuvA_I
IPR003583 Hlx-hairpin-Hlx_DNA-bd_motif
IPR012340 NA-bd_OB-fold
IPR000085 RuvA
IPR010994 RuvA_2-like
IPR011114 RuvA_C
IPR036267 RuvA_C_sf
PANTHERiPTHR33796 PTHR33796, 1 hit
PfamiView protein in Pfam
PF07499 RuvA_C, 1 hit
PF01330 RuvA_N, 1 hit
SMARTiView protein in SMART
SM00278 HhH1, 2 hits
SUPFAMiSSF46929 SSF46929, 1 hit
SSF47781 SSF47781, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00084 ruvA, 1 hit

Sequencei

Sequence statusi: Complete.

A4YMC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIGKLRGLID SYAEDFVIID VGGVGYQVHC SARTLQALPS PGEAATLSIE
60 70 80 90 100
TYVREDQIKL FGFRSDVERE WFRLLQTVQG VGAKVALAVL GTLPPADLGN
110 120 130 140 150
AIALRDKAAV ARTPGVGPKV AERIVTELKD KAPAFANVDP GVVRLSGAIE
160 170 180 190 200
ESRAPQPVAD AISALINLGY GQPQAAAAIA AASRAAGDKA ETAQLIRLGL

KELAK
Length:205
Mass (Da):21,452
Last modified:May 29, 2007 - v1
Checksum:i536E240FABB2D56C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU234118 Genomic DNA Translation: CAL75052.1
RefSeqiWP_011924296.1, NC_009445.1

Genome annotation databases

EnsemblBacteriaiCAL75052; CAL75052; BRADO1145
KEGGibra:BRADO1145

Similar proteinsi

Entry informationi

Entry nameiRUVA_BRASO
AccessioniPrimary (citable) accession number: A4YMC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: May 23, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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