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A4YM47

- MASZ_BRASO

UniProt

A4YM47 - MASZ_BRASO

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Protein
Malate synthase G
Gene
glcB, BRADO1059
Organism
Bradyrhizobium sp. (strain ORS278)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA By similarity.UniRule annotation

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei117 – 1171Acetyl-CoA; via carbonyl oxygen By similarity
Binding sitei274 – 2741Acetyl-CoA By similarity
Binding sitei311 – 3111Acetyl-CoA By similarity
Active sitei338 – 3381Proton acceptor By similarity
Binding sitei338 – 3381Glyoxylate By similarity
Metal bindingi430 – 4301Magnesium By similarity
Binding sitei430 – 4301Glyoxylate By similarity
Metal bindingi458 – 4581Magnesium By similarity
Binding sitei539 – 5391Acetyl-CoA; via carbonyl oxygen By similarity
Active sitei629 – 6291Proton donor By similarity

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-HAMAP
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciBSP114615:GJN5-1011-MONOMER.
UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase G (EC:2.3.3.9)
Gene namesi
Name:glcB
Ordered Locus Names:BRADO1059
OrganismiBradyrhizobium sp. (strain ORS278)
Taxonomic identifieri114615 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
ProteomesiUP000001994: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 724724Malate synthase GUniRule annotation
PRO_1000056896Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei615 – 6151Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi114615.BRADO1059.

Structurei

3D structure databases

ProteinModelPortaliA4YM47.
SMRiA4YM47. Positions 9-718.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni124 – 1252Acetyl-CoA binding By similarity
Regioni455 – 4584Glyoxylate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2225.
HOGENOMiHOG000220740.
KOiK01638.
OMAiSQFIENE.
OrthoDBiEOG6HJ286.

Family and domain databases

Gene3Di2.170.170.11. 2 hits.
HAMAPiMF_00641. Malate_synth_G.
InterProiIPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01345. malate_syn_G. 1 hit.

Sequencei

Sequence statusi: Complete.

A4YM47-1 [UniParc]FASTAAdd to Basket

« Hide

MTRIDAHGLK IAPVLFDFIT KEAAPKTGID PDAFWAGVAA ILRDLGSKNR    50
ELLKFRDTLQ DKIDAWHLAN KGKAFDLGAY TAFLKEIGYL LPEPATQKVE 100
TANVDDEIGK ICGPQLVVPL TNARYALNAA NARWGSLYDA FYGTDAIPHD 150
PSEGGKGYNK ARGDKVIAKA KAFLDAAAPL ATGSHTDVTA YSVIAGQLSA 200
KLKSGNATAL KNAGQFAGYQ GSAEAPSVIL LANNGLHVEV VIDRSHVIGK 250
DDPAGVSDMI LEAAVSTILD MEDSVAAVDA EDKVLVYRNT LGLMNGTLSA 300
DFEKGGKTLT RALNSDRSYT TPSGGTLALH GRSLLLIRNC GHHMFTDAVL 350
GADGEEIPEG ILDAAVTGLL AIHDLKGHSK VKNSRTGSIY IVKPKMHGPD 400
EVALTVELFA RVEKMLGLPE NTMKVGIMDE ERRTTVNLKA CIQQASKRIV 450
FINTGFLDRT GDEIHTSMEA GPMIRKNEMK AQPWIKAYED WNVDMGLIDG 500
LPGHAQIGKG MWAAPDKMAD MLAQKIGHPS AGATTAWVPS PTAATLHALH 550
YHQVNVKARQ DELTKGGPRA KLGDILTIPV SNSNWAPDDV RQEIDNNCQG 600
ILGYVVRWID QGVGCSKVPD IHDVGLMEDR ATLRISSQHL ANWLHHGVVS 650
KDQVMDSLKR MAVVVDKQNA GDPLYQPMAP SFDGVAFKAA CDLVFEGRTQ 700
PNGYTEYILT ARRREAKASE TAKA 724
Length:724
Mass (Da):78,074
Last modified:May 29, 2007 - v1
Checksum:iA5916C8C3EBD7D52
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU234118 Genomic DNA. Translation: CAL74973.1.
RefSeqiWP_011924220.1. NC_009445.1.
YP_001203210.1. NC_009445.1.

Genome annotation databases

EnsemblBacteriaiCAL74973; CAL74973; BRADO1059.
GeneIDi5114900.
KEGGibra:BRADO1059.
PATRICi21218351. VBIBraSp122330_1004.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU234118 Genomic DNA. Translation: CAL74973.1 .
RefSeqi WP_011924220.1. NC_009445.1.
YP_001203210.1. NC_009445.1.

3D structure databases

ProteinModelPortali A4YM47.
SMRi A4YM47. Positions 9-718.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 114615.BRADO1059.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL74973 ; CAL74973 ; BRADO1059 .
GeneIDi 5114900.
KEGGi bra:BRADO1059.
PATRICi 21218351. VBIBraSp122330_1004.

Phylogenomic databases

eggNOGi COG2225.
HOGENOMi HOG000220740.
KOi K01638.
OMAi SQFIENE.
OrthoDBi EOG6HJ286.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00720 .
BioCyci BSP114615:GJN5-1011-MONOMER.

Family and domain databases

Gene3Di 2.170.170.11. 2 hits.
HAMAPi MF_00641. Malate_synth_G.
InterProi IPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view ]
Pfami PF01274. Malate_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF51645. SSF51645. 1 hit.
TIGRFAMsi TIGR01345. malate_syn_G. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ORS278.

Entry informationi

Entry nameiMASZ_BRASO
AccessioniPrimary (citable) accession number: A4YM47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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