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A4YK54

- PNCB_BRASO

UniProt

A4YK54 - PNCB_BRASO

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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Bradyrhizobium sp. (strain ORS278)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciBSP114615:GJN5-312-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:BRADO0323
OrganismiBradyrhizobium sp. (strain ORS278)
Taxonomic identifieri114615 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
ProteomesiUP000001994: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Nicotinate phosphoribosyltransferasePRO_1000146834Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi114615.BRADO0323.

Structurei

3D structure databases

ProteinModelPortaliA4YK54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284929.
KOiK00763.
OMAiQAVFHRY.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

A4YK54-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTVTDIASRT YNHGWRLDPI VRSLLDTDFY KLLMLQMIRE FYPDQKVTFS
60 70 80 90 100
VINRTKRVRL GDVIDEGELR AQLDHARTIR FSKKELIWLA GNTFYGKTHM
110 120 130 140 150
FSPDFLAWLA NFRLPEYELH KADGQYELHF HGLWTHTTMW EIPALAIVNE
160 170 180 190 200
LRSRQAMKGQ GRFALDVLFA RAKAKLWAKV ERLRKLEGLR LSDFGTRRRH
210 220 230 240 250
GFLWQRWCVE AVKEGLGSSF TGTSNVLLAM DNDLEAIGTN AHELPMVAAA
260 270 280 290 300
LAKDDDELRF APYRILDQWR QTYAGNLLIA LPDAFGTKAF LRDAPDWVAD
310 320 330 340 350
WTGFRPDSAP PIQAGEEIIA WWKSKGRDPR QKLLVFSDAM DVESIEQIHQ
360 370 380 390 400
RFSDQVRLSF GWGTNLTNDF VGCSPDGSVD LDPISLVCKV TSVDGRPAVK
410 420 430
LSDNPEKATG DPAEIARYLR VFGDAGRVRT PVFV
Length:434
Mass (Da):49,506
Last modified:May 29, 2007 - v1
Checksum:i23B98C80298AFC4D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU234118 Genomic DNA. Translation: CAL74280.1.
RefSeqiWP_011923561.1. NC_009445.1.
YP_001202526.1. NC_009445.1.

Genome annotation databases

EnsemblBacteriaiCAL74280; CAL74280; BRADO0323.
GeneIDi5116171.
KEGGibra:BRADO0323.
PATRICi21216962. VBIBraSp122330_0314.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU234118 Genomic DNA. Translation: CAL74280.1 .
RefSeqi WP_011923561.1. NC_009445.1.
YP_001202526.1. NC_009445.1.

3D structure databases

ProteinModelPortali A4YK54.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 114615.BRADO0323.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL74280 ; CAL74280 ; BRADO0323 .
GeneIDi 5116171.
KEGGi bra:BRADO0323.
PATRICi 21216962. VBIBraSp122330_0314.

Phylogenomic databases

eggNOGi COG1488.
HOGENOMi HOG000284929.
KOi K00763.
OMAi QAVFHRY.
OrthoDBi EOG6X10XB.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .
BioCyci BSP114615:GJN5-312-MONOMER.

Family and domain databases

HAMAPi MF_00570. NAPRTase.
InterProi IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 1 hit.
TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ORS278.

Entry informationi

Entry nameiPNCB_BRASO
AccessioniPrimary (citable) accession number: A4YK54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 29, 2007
Last modified: October 1, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3