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A4YJX9

- ASSY_BRASO

UniProt

A4YJX9 - ASSY_BRASO

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Protein

Argininosuccinate synthase

Gene
argG, BRADO0243
Organism
Bradyrhizobium sp. (strain ORS278)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei43 – 431ATP By similarity
Binding sitei99 – 991Citrulline By similarity
Binding sitei129 – 1291ATP; via amide nitrogen By similarity
Binding sitei131 – 1311Aspartate By similarity
Binding sitei131 – 1311ATP By similarity
Binding sitei135 – 1351Aspartate By similarity
Binding sitei135 – 1351Citrulline By similarity
Binding sitei136 – 1361Aspartate By similarity
Binding sitei136 – 1361ATP By similarity
Binding sitei139 – 1391Citrulline By similarity
Binding sitei192 – 1921Citrulline By similarity
Binding sitei194 – 1941ATP By similarity
Binding sitei201 – 2011Citrulline By similarity
Binding sitei203 – 2031Citrulline By similarity
Binding sitei280 – 2801Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi17 – 259ATP By similarity

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSP114615:GJN5-234-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:BRADO0243
OrganismiBradyrhizobium sp. (strain ORS278)
Taxonomic identifieri114615 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
ProteomesiUP000001994: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Argininosuccinate synthaseUniRule annotationPRO_1000129735Add
BLAST

Proteomic databases

PRIDEiA4YJX9.

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi114615.BRADO0243.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230094.
KOiK01940.
OMAiRQEMSEF.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di1.10.287.400. 1 hit.
3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00581. Arg_succ_synth_type2.
InterProiIPR023437. Arg_succ_synth_type2_subfam.
IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR024074. AS_cat/multimer_dom_body.
IPR024073. AS_multimer_C_tail.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4YJX9-1 [UniParc]FASTAAdd to Basket

« Hide

MTTILKGLPT GEKVGIAFSG GLDTSAALLW MKQKGARCFA YTANLGQPDE    50
SDYDEIPRKA MSFGAEKARL VDCRTQLVHE GIAAIQSGAF HISTGGATYF 100
NTTPLGRAVT GTMLVAAMKE DGVNIWGDGS TYKGNDIERF YRYGLLTNPN 150
LKIYKPWLDQ QFIDELGGRA EMSAFLTAHG FNYKMSAEKA YSTDSNLLGA 200
THEAKDLESL SSGIRIVNPI MGVPFWREDC AVRPETVVVR FEEGQPVALN 250
GQTFTDPVAL FLEANAIGGR HGLGMCDQIE NRIIEAKSRG IYEAPGMALL 300
HIAYERLVTG IHNEDTIEQY RMSGMKLGRL LYQGRWFDSQ ALMLRETAQR 350
WVASAITGEV TLELRRGNDY SLLNTESPNL TYQPERLSME KVEDAAFTPA 400
DRIGQLTMRN LDITDTRTKL KLYSDTGLLS GAEGAQIFQL GHDKGDKS 448
Length:448
Mass (Da):49,427
Last modified:May 29, 2007 - v1
Checksum:i865800638631F323
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU234118 Genomic DNA. Translation: CAL74205.1.
RefSeqiWP_011923492.1. NC_009445.1.
YP_001202455.1. NC_009445.1.

Genome annotation databases

EnsemblBacteriaiCAL74205; CAL74205; BRADO0243.
GeneIDi5116656.
KEGGibra:BRADO0243.
PATRICi21216810. VBIBraSp122330_0241.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU234118 Genomic DNA. Translation: CAL74205.1 .
RefSeqi WP_011923492.1. NC_009445.1.
YP_001202455.1. NC_009445.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 114615.BRADO0243.

Proteomic databases

PRIDEi A4YJX9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL74205 ; CAL74205 ; BRADO0243 .
GeneIDi 5116656.
KEGGi bra:BRADO0243.
PATRICi 21216810. VBIBraSp122330_0241.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230094.
KOi K01940.
OMAi RQEMSEF.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci BSP114615:GJN5-234-MONOMER.

Family and domain databases

Gene3Di 1.10.287.400. 1 hit.
3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00581. Arg_succ_synth_type2.
InterProi IPR023437. Arg_succ_synth_type2_subfam.
IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR024074. AS_cat/multimer_dom_body.
IPR024073. AS_multimer_C_tail.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ORS278.

Entry informationi

Entry nameiASSY_BRASO
AccessioniPrimary (citable) accession number: A4YJX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 29, 2007
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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