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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Bradyrhizobium sp. (strain ORS278)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. dephosphorylation Source: InterPro
  3. peptidoglycan biosynthetic process Source: UniProtKB-KW
  4. regulation of cell shape Source: UniProtKB-KW
  5. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciBSP114615:GJN5-127-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:BRADO0129
OrganismiBradyrhizobium sp. (strain ORS278)
Taxonomic identifieri114615 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
ProteomesiUP000001994 Componenti: Chromosome

Subcellular locationi

  1. Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei47 – 6721HelicalUniRule annotationAdd
BLAST
Transmembranei83 – 10321HelicalUniRule annotationAdd
BLAST
Transmembranei109 – 12921HelicalUniRule annotationAdd
BLAST
Transmembranei144 – 16421HelicalUniRule annotationAdd
BLAST
Transmembranei184 – 20421HelicalUniRule annotationAdd
BLAST
Transmembranei218 – 23821HelicalUniRule annotationAdd
BLAST
Transmembranei246 – 26621HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 268268Undecaprenyl-diphosphatasePRO_0000303021Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi114615.BRADO0129.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiAQCFALI.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

A4YJM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSDTLRAVL LGIVEGVTEF LPVSSTGHLL LAERFFGLGE DGFWKSFAIL
60 70 80 90 100
IQLGAILAIV ALYFFKLSRV AIGALTNPDD RRFIIGVLIA FLPAVIIGLI
110 120 130 140 150
AGKYIKALLF DPWVVCFSLI VGGAILLWVD QIDLKPREHD ATRYPLMMYL
160 170 180 190 200
WIGVAQCLAM IPGVSRSGST IVAAMLLGGD KRSAAEFSFF LAIPTMVGAF
210 220 230 240 250
VYDFYKSRAE MTSDHLGLIA IGFVVSFITA MIVVKAFLGY VTRHGFVLFA
260
WWRVIVGTLG LIALALGK
Length:268
Mass (Da):29,260
Last modified:May 29, 2007 - v1
Checksum:i04B60565BDAA7369
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU234118 Genomic DNA. Translation: CAL74098.1.
RefSeqiWP_011923396.1. NC_009445.1.
YP_001202348.1. NC_009445.1.

Genome annotation databases

EnsemblBacteriaiCAL74098; CAL74098; BRADO0129.
KEGGibra:BRADO0129.
PATRICi21216590. VBIBraSp122330_0131.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU234118 Genomic DNA. Translation: CAL74098.1.
RefSeqiWP_011923396.1. NC_009445.1.
YP_001202348.1. NC_009445.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi114615.BRADO0129.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL74098; CAL74098; BRADO0129.
KEGGibra:BRADO0129.
PATRICi21216590. VBIBraSp122330_0131.

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiAQCFALI.
OrthoDBiEOG6QP13M.

Enzyme and pathway databases

BioCyciBSP114615:GJN5-127-MONOMER.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ORS278.

Entry informationi

Entry nameiUPPP_BRASO
AccessioniPrimary (citable) accession number: A4YJM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 29, 2007
Last modified: April 1, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.