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Protein

Tryptophan synthase beta chain

Gene

trpB

Organism
Bradyrhizobium sp. (strain ORS 278)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.UniRule annotation

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBSP114615:GJN5-89-MONOMER.
UniPathwayiUPA00035; UER00044.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase beta chainUniRule annotation (EC:4.2.1.20UniRule annotation)
Gene namesi
Name:trpBUniRule annotation
Ordered Locus Names:BRADO0091
OrganismiBradyrhizobium sp. (strain ORS 278)
Taxonomic identifieri114615 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
Proteomesi
  • UP000001994 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407Tryptophan synthase beta chainPRO_1000018328Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei98 – 981N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains.UniRule annotation

Protein-protein interaction databases

STRINGi114615.BRADO0091.

Structurei

3D structure databases

ProteinModelPortaliA4YJI6.
SMRiA4YJI6. Positions 18-400.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CG0. Bacteria.
COG0133. LUCA.
HOGENOMiHOG000161710.
KOiK01696.
OMAiEHSWLND.
OrthoDBiPOG091H02JY.

Family and domain databases

HAMAPiMF_00133. Trp_synth_beta. 1 hit.
InterProiIPR006653. Trp_synth_b_CS.
IPR006654. Trp_synth_beta.
IPR023026. Trp_synth_beta/beta-like.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PANTHERiPTHR10314:SF3. PTHR10314:SF3. 1 hit.
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF001413. Trp_syn_beta. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00263. trpB. 1 hit.
PROSITEiPS00168. TRP_SYNTHASE_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4YJI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTAIPNSYR SGPDERGHFG IFGGRFVAET LMPLILDLEK AYADAKADPA
60 70 80 90 100
FQGEMNSYRT HYVGRPSPLY YAERLTEHLG GAKIYFKRDE LNHTGSHKVN
110 120 130 140 150
NVLGQIMLAR RMGKKRIIAE TGAGQHGVAT ATLCARFGLD CVVYMGAVDV
160 170 180 190 200
ERQQPNVLRM EMLGAKVIPV QSGARTLKDA MNEALRDWVT NVHNTFYCIG
210 220 230 240 250
TVAGPHPYPM MVRDFQSVIG QETRTQMQEA EGRLPDSLVA CIGGGSNAMG
260 270 280 290 300
LFHPFLDDPS VEIFGVEAAG HGLTQLHAAS IAGGRPGVLH GNRTYLLMDD
310 320 330 340 350
DGQIAEAHSI SAGLDYPGIG PEHSWLHEAK RVTYLSATDD EALDAFLLLS
360 370 380 390 400
RLEGIIPALE PAHAVAKVMQ LAPNKPKDHL MVVNLCGRGD KDVPQVGEIL

RKRAKQS
Length:407
Mass (Da):44,347
Last modified:May 29, 2007 - v1
Checksum:i4F7EE26963382AE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU234118 Genomic DNA. Translation: CAL74062.1.
RefSeqiWP_011923362.1. NC_009445.1.

Genome annotation databases

EnsemblBacteriaiCAL74062; CAL74062; BRADO0091.
KEGGibra:BRADO0091.
PATRICi21216512. VBIBraSp122330_0094.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU234118 Genomic DNA. Translation: CAL74062.1.
RefSeqiWP_011923362.1. NC_009445.1.

3D structure databases

ProteinModelPortaliA4YJI6.
SMRiA4YJI6. Positions 18-400.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi114615.BRADO0091.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL74062; CAL74062; BRADO0091.
KEGGibra:BRADO0091.
PATRICi21216512. VBIBraSp122330_0094.

Phylogenomic databases

eggNOGiENOG4105CG0. Bacteria.
COG0133. LUCA.
HOGENOMiHOG000161710.
KOiK01696.
OMAiEHSWLND.
OrthoDBiPOG091H02JY.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00044.
BioCyciBSP114615:GJN5-89-MONOMER.

Family and domain databases

HAMAPiMF_00133. Trp_synth_beta. 1 hit.
InterProiIPR006653. Trp_synth_b_CS.
IPR006654. Trp_synth_beta.
IPR023026. Trp_synth_beta/beta-like.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PANTHERiPTHR10314:SF3. PTHR10314:SF3. 1 hit.
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF001413. Trp_syn_beta. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00263. trpB. 1 hit.
PROSITEiPS00168. TRP_SYNTHASE_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRPB_BRASO
AccessioniPrimary (citable) accession number: A4YJI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: September 7, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.