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Protein

Geranylgeranylglyceryl phosphate synthase

Gene

Msed_2291

Organism
Metallosphaera sedula (strain ATCC 51363 / DSM 5348)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.UniRule annotation

Catalytic activityi

Geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: glycerophospholipid metabolism

This protein is involved in the pathway glycerophospholipid metabolism, which is part of Membrane lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycerophospholipid metabolism and in Membrane lipid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi27 – 271MagnesiumUniRule annotation
Metal bindingi57 – 571MagnesiumUniRule annotation
Binding sitei207 – 2071Glycerol-1-phosphate; via amide nitrogenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciMSED399549:GH1O-2338-MONOMER.
UniPathwayiUPA00940.

Names & Taxonomyi

Protein namesi
Recommended name:
Geranylgeranylglyceryl phosphate synthaseUniRule annotation (EC:2.5.1.41UniRule annotation)
Short name:
GGGP synthaseUniRule annotation
Short name:
GGGPSUniRule annotation
Alternative name(s):
(S)-3-O-geranylgeranylglyceryl phosphate synthaseUniRule annotation
Phosphoglycerol geranylgeranyltransferaseUniRule annotation
Gene namesi
Ordered Locus Names:Msed_2291
OrganismiMetallosphaera sedula (strain ATCC 51363 / DSM 5348)
Taxonomic identifieri399549 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeMetallosphaera
Proteomesi
  • UP000000242 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 252252Geranylgeranylglyceryl phosphate synthasePRO_1000071333Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399549.Msed_2291.

Structurei

3D structure databases

ProteinModelPortaliA4YJ26.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni175 – 1773Glycerol-1-phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the GGGP/HepGP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01085. Archaea.
COG1646. LUCA.
HOGENOMiHOG000034117.
KOiK17104.
OMAiEPIPMAY.

Family and domain databases

Gene3Di3.20.20.390. 1 hit.
HAMAPiMF_00112. GGGP_HepGP_synthase.
InterProiIPR008205. GGGP_HepGP_synthase.
IPR010946. GGGP_synth.
[Graphical view]
PfamiPF01884. PcrB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01769. GGGP. 1 hit.
TIGR01768. GGGP-family. 1 hit.

Sequencei

Sequence statusi: Complete.

A4YJ26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIKGKTAKY LQKLIDEGQP IHFSLIDPDK VKDIQSLSKV ASSLFKAGTS
60 70 80 90 100
AFLIGGTLGV SKEKLDSILS VLQDFSVPKI IFPSNINLIS EKADAILFMS
110 120 130 140 150
LLNSDDLYYV IGAQVSASII VKTIGLEPIP TGYLIVGHGG TAAHIGRARV
160 170 180 190 200
VPYDNPELAV AYALAAEYMG MEYLYLEAGS GAPDTVRPEM VKFVSKYSEI
210 220 230 240 250
NLIVGGGIRT PERAVELVKA GAKALVTGNV IETDIERAIK IIEAMQRVYR

IE
Length:252
Mass (Da):27,259
Last modified:May 29, 2007 - v1
Checksum:iC099C335A97DD3BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000682 Genomic DNA. Translation: ABP96428.1.

Genome annotation databases

EnsemblBacteriaiABP96428; ABP96428; Msed_2291.
KEGGimse:Msed_2291.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000682 Genomic DNA. Translation: ABP96428.1.

3D structure databases

ProteinModelPortaliA4YJ26.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi399549.Msed_2291.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP96428; ABP96428; Msed_2291.
KEGGimse:Msed_2291.

Phylogenomic databases

eggNOGiarCOG01085. Archaea.
COG1646. LUCA.
HOGENOMiHOG000034117.
KOiK17104.
OMAiEPIPMAY.

Enzyme and pathway databases

UniPathwayiUPA00940.
BioCyciMSED399549:GH1O-2338-MONOMER.

Family and domain databases

Gene3Di3.20.20.390. 1 hit.
HAMAPiMF_00112. GGGP_HepGP_synthase.
InterProiIPR008205. GGGP_HepGP_synthase.
IPR010946. GGGP_synth.
[Graphical view]
PfamiPF01884. PcrB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01769. GGGP. 1 hit.
TIGR01768. GGGP-family. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of the metal-mobilizing, extremely thermoacidophilic archaeon Metallosphaera sedula provides insights into bioleaching-associated metabolism."
    Auernik K.S., Maezato Y., Blum P.H., Kelly R.M.
    Appl. Environ. Microbiol. 74:682-692(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51363 / DSM 5348.

Entry informationi

Entry nameiGGGPS_METS5
AccessioniPrimary (citable) accession number: A4YJ26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 29, 2007
Last modified: November 11, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.