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Protein

Geranylgeranylglyceryl phosphate synthase

Gene

Msed_2291

Organism
Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.UniRule annotation

Catalytic activityi

Geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: glycerophospholipid metabolism

This protein is involved in the pathway glycerophospholipid metabolism, which is part of Membrane lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycerophospholipid metabolism and in Membrane lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi27MagnesiumUniRule annotation1
Metal bindingi57MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandMagnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00940

Names & Taxonomyi

Protein namesi
Recommended name:
Geranylgeranylglyceryl phosphate synthaseUniRule annotation (EC:2.5.1.41UniRule annotation)
Short name:
GGGP synthaseUniRule annotation
Short name:
GGGPSUniRule annotation
Alternative name(s):
(S)-3-O-geranylgeranylglyceryl phosphate synthaseUniRule annotation
Phosphoglycerol geranylgeranyltransferaseUniRule annotation
Gene namesi
Ordered Locus Names:Msed_2291
OrganismiMetallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
Taxonomic identifieri399549 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeMetallosphaera
Proteomesi
  • UP000000242 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000713331 – 252Geranylgeranylglyceryl phosphate synthaseAdd BLAST252

Interactioni

Protein-protein interaction databases

STRINGi399549.Msed_2291

Structurei

3D structure databases

ProteinModelPortaliA4YJ26
SMRiA4YJ26
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni175 – 181Glycerol-1-phosphate bindingUniRule annotation7
Regioni206 – 207Glycerol-1-phosphate bindingUniRule annotation2
Regioni228 – 229Glycerol-1-phosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the GGGP/HepGP synthase family. Group II subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01085 Archaea
COG1646 LUCA
HOGENOMiHOG000034117
KOiK17104
OMAiADAIFFM
OrthoDBiPOG093Z0C46

Family and domain databases

CDDicd02812 PcrB_like, 1 hit
Gene3Di3.20.20.390, 1 hit
HAMAPiMF_00112 GGGP_HepGP_synthase, 1 hit
InterProiView protein in InterPro
IPR038597 GGGP/HepGP_synthase_sf
IPR008205 GGGP_HepGP_synthase
IPR010946 GGGP_synth
PfamiView protein in Pfam
PF01884 PcrB, 1 hit
TIGRFAMsiTIGR01769 GGGP, 1 hit
TIGR01768 GGGP-family, 1 hit

Sequencei

Sequence statusi: Complete.

A4YJ26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIKGKTAKY LQKLIDEGQP IHFSLIDPDK VKDIQSLSKV ASSLFKAGTS
60 70 80 90 100
AFLIGGTLGV SKEKLDSILS VLQDFSVPKI IFPSNINLIS EKADAILFMS
110 120 130 140 150
LLNSDDLYYV IGAQVSASII VKTIGLEPIP TGYLIVGHGG TAAHIGRARV
160 170 180 190 200
VPYDNPELAV AYALAAEYMG MEYLYLEAGS GAPDTVRPEM VKFVSKYSEI
210 220 230 240 250
NLIVGGGIRT PERAVELVKA GAKALVTGNV IETDIERAIK IIEAMQRVYR

IE
Length:252
Mass (Da):27,259
Last modified:May 29, 2007 - v1
Checksum:iC099C335A97DD3BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000682 Genomic DNA Translation: ABP96428.1
RefSeqiWP_012022215.1, NC_009440.1

Genome annotation databases

EnsemblBacteriaiABP96428; ABP96428; Msed_2291
GeneIDi5104242
KEGGimse:Msed_2291

Similar proteinsi

Entry informationi

Entry nameiGGGPS_METS5
AccessioniPrimary (citable) accession number: A4YJ26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 29, 2007
Last modified: March 28, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health