A4YIX4 (APGM_METS5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2,3-bisphosphoglycerate-independent phosphoglycerate mutase
Short name=BPG-independent PGAM
Short name=Phosphoglyceromutase
Short name=aPGAM
EC=5.4.2.1

Gene names

Name:	apgM
Ordered Locus Names:	Msed_2238

Organism

Metallosphaera sedula (strain ATCC 51363 / DSM 5348) [Complete proteome] [HAMAP]

Taxonomic identifier

399549 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Metallosphaera

Protein attributes

Sequence length	413 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate By similarity. HAMAP MF_01402_A
Catalytic activity	2-phospho-D-glycerate = 3-phospho-D-glycerate. HAMAP MF_01402_A
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. HAMAP MF_01402_A
Sequence similarities	Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.

Ontologies

Keywords
Biological process	Glycolysis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: InterPro phosphoglycerate mutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 413	413	2,3-bisphosphoglycerate-independent phosphoglycerate mutase HAMAP MF_01402_A		PRO_1000073505

Sequences

	Sequence		Length	Mass (Da)
	A4YIX4 [UniParc]. Last modified May 29, 2007. Version 1. Checksum: 21C3491B15C8BEDF	FASTA	413	44,562
	10 20 30 40 50 60 MKKYKILLVI GDGLGDRQVA SLNGRTPLEN ADKPTIASLL RSSLVGLMDP IGPGIVPGSD 70 80 90 100 110 120 TSHLAIFGLD PKKYYKGRGS FEALGAGAIL TEGDIAFRGN FATVDSNLVV IDRRAGRKIE 130 140 150 160 170 180 EAEDLVKELN DKIQEIDGVK VRFYHGTEHR VSVVLSGDNL SDKVSDTDPH EVGKRILNSE 190 200 210 220 230 240 PTDDALSSKR TANIINALTR RIYEVLSNSQ LNDKRVREGL PPANIVLLRG ASIHTELPKL 250 260 270 280 290 300 KDYTGLSGAA VSATALIKGV CKSLGMEVVT PPGATGGIDT DYMAKAEAAA KLLEDHDLVF 310 320 330 340 350 360 LHIKATDAAS HDGKVSEKVK AIEMIDRSIG RVLDRYGSEL VVLFTGDHAT PVELREHSGD 370 380 390 400 410 PVPLMLYVPT NIIPDNVGDF NERQARKGSL KITGLNIIDL LLNFSNRATK YGA

References

[1]

"The genome sequence of the metal-mobilizing, extremely thermoacidophilic archaeon Metallosphaera sedula provides insights into bioleaching-associated metabolism." Auernik K.S., Maezato Y., Blum P.H., Kelly R.M. Appl. Environ. Microbiol. 74:682-692(2008) [PubMed: 18083856] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51363 / DSM 5348.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000682 Genomic DNA. Translation: ABP96376.1.
RefSeq	YP_001192300.1. NC_009440.1.
3D structure databases
ProteinModelPortal	A4YIX4.
ModBase	Search...
Protein-protein interaction databases
STRING	A4YIX4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5104299.
GenomeReviews	Gene locus Msed_2238 in contig CP000682_GR.
KEGG	mse:Msed_2238.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG04733.
HOGENOM	HBG463247.
OMA	DIAFRCN.
ProtClustDB	PRK04024.
Enzyme and pathway databases
BioCyc	MSED399549:MSED_2238-MONOMER.
Family and domain databases
HAMAP	MF_01402_A. ApgM_A. [Tree]
InterPro	IPR017849. Alkaline_Pase-like_a/b/a. IPR017850. Alkaline_phosphatase_core. IPR023665. ApgAM. IPR004456. BisP-indep_Pglycerate_Mutase. IPR006124. Metalloenzyme. [Graphical view]
Gene3D	G3DSA:3.40.720.10. Alk_phosphtse. 2 hits.
KO	K15635.
Pfam	PF01676. Metalloenzyme. 1 hit. PF10143. PhosphMutase. 1 hit. [Graphical view]
PIRSF	PIRSF006392. IPGAM_arch. 1 hit.
SUPFAM	SSF53649. Alkaline_phosphatase_core. 1 hit.
TIGRFAMs	TIGR00306. ApgM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APGM_METS5

Accession

Primary (citable) accession number: A4YIX4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	May 29, 2007
Last modified:	January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program