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A4YIL8

- SYE_METS5

UniProt

A4YIL8 - SYE_METS5

Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Metallosphaera sedula (strain ATCC 51363 / DSM 5348)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (29 May 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

    Catalytic activityi

    ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMSED399549:GH1O-2165-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
    Alternative name(s):
    Glutamyl-tRNA synthetaseUniRule annotation
    Short name:
    GluRSUniRule annotation
    Gene namesi
    Name:gltXUniRule annotation
    Ordered Locus Names:Msed_2131
    OrganismiMetallosphaera sedula (strain ATCC 51363 / DSM 5348)
    Taxonomic identifieri399549 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeMetallosphaera
    ProteomesiUP000000242: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 566566Glutamate--tRNA ligasePRO_1000071001Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi399549.Msed_2131.

    Structurei

    3D structure databases

    ProteinModelPortaliA4YIL8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi104 – 11411"HIGH" regionAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0008.
    HOGENOMiHOG000073585.
    KOiK01885.
    OMAiAFRIIDT.

    Family and domain databases

    Gene3Di1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_00022_A. Glu_tRNA_synth_A.
    InterProiIPR004526. Glu-tRNA-synth_arc/euk.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR022888. Glu_tRNA_synth_arc.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF50715. SSF50715. 1 hit.
    TIGRFAMsiTIGR00463. gltX_arch. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4YIL8-1 [UniParc]FASTAAdd to Basket

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    MTMELEEIVY KYALWNAVKH NGQAQVGPVV SKVFAERPEL KANAKEVVKL    50
    AEKMVAKVNA MSLEQQTAEL QKYPELLEER KKEEKKTLSP LPNVKGTVVT 100
    RFAPNPDGPL HLGNARAAVL SFEYAKMYKG KFILRFDDTD PKVKKPIKEA 150
    YDWIRDDLRW LNITWDLEFK ASERMSAYYN VAKVMLEKGF AYVDTLSDAE 200
    FKAWRDSRNK TVYKPRTNPP EVNLELWEKM LNGDFDEGKA VVRIKTNPED 250
    PDPSKIDWVM LRIIDTKRNP HPIAGDKFRV WPTYNFATAV DDHEFGITHI 300
    LRAKEHTTNT EKQRWVYDYM GWEMPTVLEF GRLKLEGFMM SKSKIRGMLE 350
    TGSERDDPRL PTLAGLRRRG IIPDTVREII IQVGLKVTDA TISFDNIASV 400
    NRKLLDPVAK RLMFVREGVL FKLEIPQEMK AKVPLIPARQ EFREIFVKPG 450
    DEIYLDKGDV EEGKVVRLMD LCNVKIEGDR LRFLSQDLES AKRMGANIIQ 500
    WVKKSESKSV NVIKADPNKD VEEIRGYGEG YFETLKPGDI VQLVRYGFAR 550
    VDSISRGEIT MIFAHE 566
    Length:566
    Mass (Da):65,210
    Last modified:May 29, 2007 - v1
    Checksum:i9121E10FC443A779
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000682 Genomic DNA. Translation: ABP96270.1.
    RefSeqiYP_001192194.1. NC_009440.1.

    Genome annotation databases

    EnsemblBacteriaiABP96270; ABP96270; Msed_2131.
    GeneIDi5104424.
    KEGGimse:Msed_2131.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000682 Genomic DNA. Translation: ABP96270.1 .
    RefSeqi YP_001192194.1. NC_009440.1.

    3D structure databases

    ProteinModelPortali A4YIL8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 399549.Msed_2131.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP96270 ; ABP96270 ; Msed_2131 .
    GeneIDi 5104424.
    KEGGi mse:Msed_2131.

    Phylogenomic databases

    eggNOGi COG0008.
    HOGENOMi HOG000073585.
    KOi K01885.
    OMAi AFRIIDT.

    Enzyme and pathway databases

    BioCyci MSED399549:GH1O-2165-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_00022_A. Glu_tRNA_synth_A.
    InterProi IPR004526. Glu-tRNA-synth_arc/euk.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR022888. Glu_tRNA_synth_arc.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF50715. SSF50715. 1 hit.
    TIGRFAMsi TIGR00463. gltX_arch. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the metal-mobilizing, extremely thermoacidophilic archaeon Metallosphaera sedula provides insights into bioleaching-associated metabolism."
      Auernik K.S., Maezato Y., Blum P.H., Kelly R.M.
      Appl. Environ. Microbiol. 74:682-692(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51363 / DSM 5348.

    Entry informationi

    Entry nameiSYE_METS5
    AccessioniPrimary (citable) accession number: A4YIL8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3