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A4YI75

- ASSY_METS5

UniProt

A4YI75 - ASSY_METS5

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Protein

Argininosuccinate synthase

Gene
argG, Msed_1987
Organism
Metallosphaera sedula (strain ATCC 51363 / DSM 5348)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei84 – 841Citrulline By similarity
Binding sitei114 – 1141ATP; via amide nitrogen By similarity
Binding sitei116 – 1161Aspartate By similarity
Binding sitei120 – 1201Aspartate By similarity
Binding sitei120 – 1201Citrulline By similarity
Binding sitei121 – 1211Aspartate By similarity
Binding sitei124 – 1241Citrulline By similarity
Binding sitei171 – 1711Citrulline By similarity
Binding sitei180 – 1801Citrulline By similarity
Binding sitei253 – 2531Citrulline By similarity
Binding sitei265 – 2651Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi6 – 149ATP By similarity

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMSED399549:GH1O-2018-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:Msed_1987
OrganismiMetallosphaera sedula (strain ATCC 51363 / DSM 5348)
Taxonomic identifieri399549 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeMetallosphaera
ProteomesiUP000000242: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 391391Argininosuccinate synthaseUniRule annotationPRO_1000070914Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi399549.Msed_1987.

Structurei

3D structure databases

ProteinModelPortaliA4YI75.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4YI75-1 [UniParc]FASTAAdd to Basket

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MKIVLAYSGG LDTTVAIKWL SETFHAEVIS VSVDVGQKDD FKKIEERAYK    50
AGSAKHYLVD AKREFAENFA LKDIKMNGLY EEVYPLATAL ARPLIAEKVA 100
EVAKKEGTEY VAHGSTSKGN DQVRFDLALK TALDNVKIIA PARIWKMTRE 150
DEIAYARERG IPIKTESSKY SIDENLWGRS IEGDIISDPA SEVPEDAFEW 200
TAVRKQDKLK LSVEFEKGVP VRVNGEKLDP VKLISLLNEE VGSRGFGRVE 250
HLENRVVGFK SREVYEAPAA LALIAAHKDL EKTVLTPLEL RFKRHLDSLW 300
SDLVYQGLWY EPLRNTLELA GDEINKWVSG EVKLEVDLKS LRVVGRTSPY 350
SPYSEKISSY NKGWYPSDEE ARGFIEIWGM HSLLTRKARY G 391
Length:391
Mass (Da):44,199
Last modified:May 29, 2007 - v1
Checksum:iCB7585851315C5FF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000682 Genomic DNA. Translation: ABP96127.1.
RefSeqiWP_012021914.1. NC_009440.1.
YP_001192051.1. NC_009440.1.

Genome annotation databases

EnsemblBacteriaiABP96127; ABP96127; Msed_1987.
GeneIDi5103374.
KEGGimse:Msed_1987.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000682 Genomic DNA. Translation: ABP96127.1 .
RefSeqi WP_012021914.1. NC_009440.1.
YP_001192051.1. NC_009440.1.

3D structure databases

ProteinModelPortali A4YI75.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399549.Msed_1987.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP96127 ; ABP96127 ; Msed_1987 .
GeneIDi 5103374.
KEGGi mse:Msed_1987.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci MSED399549:GH1O-2018-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the metal-mobilizing, extremely thermoacidophilic archaeon Metallosphaera sedula provides insights into bioleaching-associated metabolism."
    Auernik K.S., Maezato Y., Blum P.H., Kelly R.M.
    Appl. Environ. Microbiol. 74:682-692(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51363 / DSM 5348.

Entry informationi

Entry nameiASSY_METS5
AccessioniPrimary (citable) accession number: A4YI75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 29, 2007
Last modified: September 3, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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