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A4YI54

- A4YI54_METS5

UniProt

A4YI54 - A4YI54_METS5

Protein
Submitted name:

Orotidine-5'-phosphate decarboxylase

Gene

Msed_1966

Organism
Metallosphaera sedula (strain ATCC 51363 / DSM 5348)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (29 May 2007)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei186 – 1861Sulfate 2Imported

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    LyaseImported

    Enzyme and pathway databases

    BioCyciMSED399549:GH1O-1997-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Orotidine-5'-phosphate decarboxylaseImported (EC:4.1.1.23Imported)
    Gene namesi
    Ordered Locus Names:Msed_1966Imported
    OrganismiMetallosphaera sedula (strain ATCC 51363 / DSM 5348)Imported
    Taxonomic identifieri399549 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeMetallosphaera
    ProteomesiUP000000242: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi399549.Msed_1966.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3VE7X-ray1.54A/B1-215[»]
    3VE9X-ray1.45A/B1-215[»]
    ProteinModelPortaliA4YI54.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni139 – 1402Sulfate 1 bindingImported
    Regioni191 – 1922Sulfate 2 bindingImported

    Phylogenomic databases

    eggNOGiCOG0284.
    HOGENOMiHOG000226069.
    KOiK01591.
    OMAiTEMSHPG.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4YI54-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNRVILSLDS PIPEETLRKL NGKVAGIKVG WPLLLNLGKE KVKELVGLVD    50
    GIKILDLKLA DIDNTMILIV DELKDITNSF IAHAFVGVEG SLASLSQRVD 100
    LFLVLSMSHP GWNDAFYPYL REVARRVNPK GFVAPATRPS MISRVKGDFP 150
    DKLVISPGVG TQGAKPGIAL CHGADYEIVG RSVYQSADPV RKLEEIVRSQ 200
    EEVLSSCEGA KDRGS 215
    Length:215
    Mass (Da):23,404
    Last modified:May 29, 2007 - v1
    Checksum:iF7D9C7A64F668DCD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000682 Genomic DNA. Translation: ABP96106.1.
    RefSeqiYP_001192030.1. NC_009440.1.

    Genome annotation databases

    EnsemblBacteriaiABP96106; ABP96106; Msed_1966.
    GeneIDi5103353.
    KEGGimse:Msed_1966.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000682 Genomic DNA. Translation: ABP96106.1 .
    RefSeqi YP_001192030.1. NC_009440.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3VE7 X-ray 1.54 A/B 1-215 [» ]
    3VE9 X-ray 1.45 A/B 1-215 [» ]
    ProteinModelPortali A4YI54.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 399549.Msed_1966.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP96106 ; ABP96106 ; Msed_1966 .
    GeneIDi 5103353.
    KEGGi mse:Msed_1966.

    Phylogenomic databases

    eggNOGi COG0284.
    HOGENOMi HOG000226069.
    KOi K01591.
    OMAi TEMSHPG.

    Enzyme and pathway databases

    BioCyci MSED399549:GH1O-1997-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the metal-mobilizing, extremely thermoacidophilic archaeon Metallosphaera sedula provides insights into bioleaching-associated metabolism."
      Auernik K.S., Maezato Y., Blum P.H., Kelly R.M.
      Appl. Environ. Microbiol. 74:682-692(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51363 / DSM 5348Imported.
    2. "Crystal structure of orotidine 5'-monophosphate decarboxylase from Metallosphaera sedula complexed with inhibitor BMP."
      Fedorov E.V., Desai B., Gerlt J.A., Almo S.C., Fedorov A.A.
      Submitted (JAN-2012) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.54 ANGSTROMS).
    3. "Crystal structure of orotidine 5'-monophosphate decarboxylase from Metallosphaera sedula."
      Fedorov A.A., Fedorov E.V., Desai B., Gerlt J.A., Almo S.C.
      Submitted (JAN-2012) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS).

    Entry informationi

    Entry nameiA4YI54_METS5
    AccessioniPrimary (citable) accession number: A4YI54
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 29, 2007
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3