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A4YI54

- A4YI54_METS5

UniProt

A4YI54 - A4YI54_METS5

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Protein
Submitted name:

Orotidine-5'-phosphate decarboxylase

Gene
Msed_1966
Organism
Metallosphaera sedula (strain ATCC 51363 / DSM 5348)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei186 – 1861Sulfate 2Imported

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseImported

Enzyme and pathway databases

BioCyciMSED399549:GH1O-1997-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Orotidine-5'-phosphate decarboxylaseImported (EC:4.1.1.23Imported)
Gene namesi
Ordered Locus Names:Msed_1966Imported
OrganismiMetallosphaera sedula (strain ATCC 51363 / DSM 5348)Imported
Taxonomic identifieri399549 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeMetallosphaera
ProteomesiUP000000242: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi399549.Msed_1966.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3VE7X-ray1.54A/B1-215[»]
3VE9X-ray1.45A/B1-215[»]
ProteinModelPortaliA4YI54.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni139 – 1402Sulfate 1 bindingImported
Regioni191 – 1922Sulfate 2 bindingImported

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000226069.
KOiK01591.
OMAiTEMSHPG.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.

Sequencei

Sequence statusi: Complete.

A4YI54-1 [UniParc]FASTAAdd to Basket

« Hide

MNRVILSLDS PIPEETLRKL NGKVAGIKVG WPLLLNLGKE KVKELVGLVD    50
GIKILDLKLA DIDNTMILIV DELKDITNSF IAHAFVGVEG SLASLSQRVD 100
LFLVLSMSHP GWNDAFYPYL REVARRVNPK GFVAPATRPS MISRVKGDFP 150
DKLVISPGVG TQGAKPGIAL CHGADYEIVG RSVYQSADPV RKLEEIVRSQ 200
EEVLSSCEGA KDRGS 215
Length:215
Mass (Da):23,404
Last modified:May 29, 2007 - v1
Checksum:iF7D9C7A64F668DCD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000682 Genomic DNA. Translation: ABP96106.1.
RefSeqiYP_001192030.1. NC_009440.1.

Genome annotation databases

EnsemblBacteriaiABP96106; ABP96106; Msed_1966.
GeneIDi5103353.
KEGGimse:Msed_1966.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000682 Genomic DNA. Translation: ABP96106.1 .
RefSeqi YP_001192030.1. NC_009440.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3VE7 X-ray 1.54 A/B 1-215 [» ]
3VE9 X-ray 1.45 A/B 1-215 [» ]
ProteinModelPortali A4YI54.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399549.Msed_1966.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP96106 ; ABP96106 ; Msed_1966 .
GeneIDi 5103353.
KEGGi mse:Msed_1966.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000226069.
KOi K01591.
OMAi TEMSHPG.

Enzyme and pathway databases

BioCyci MSED399549:GH1O-1997-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of the metal-mobilizing, extremely thermoacidophilic archaeon Metallosphaera sedula provides insights into bioleaching-associated metabolism."
    Auernik K.S., Maezato Y., Blum P.H., Kelly R.M.
    Appl. Environ. Microbiol. 74:682-692(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51363 / DSM 5348.
  2. "Crystal structure of orotidine 5'-monophosphate decarboxylase from Metallosphaera sedula complexed with inhibitor BMP."
    Fedorov A.A., Fedorov E.V., Desai B., Gerlt J.A., Almo S.C.
    Submitted (JAN-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.54 ANGSTROMS).
  3. "Crystal structure of orotidine 5'-monophosphate decarboxylase from Metallosphaera sedula."
    Fedorov A.A., Fedorov E.V., Desai B., Gerlt J.A., Almo S.C.
    Submitted (JAN-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS).

Entry informationi

Entry nameiA4YI54_METS5
AccessioniPrimary (citable) accession number: A4YI54
Entry historyi
Integrated into UniProtKB/TrEMBL: May 29, 2007
Last sequence update: May 29, 2007
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome

External Data

Dasty 3

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