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A4YI54

- A4YI54_METS5

UniProt

A4YI54 - A4YI54_METS5

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Protein
Submitted name:

Orotidine-5'-phosphate decarboxylase

Gene

Msed_1966

Organism
Metallosphaera sedula (strain ATCC 51363 / DSM 5348)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei186 – 1861Sulfate 2Imported

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseImported

Enzyme and pathway databases

BioCyciMSED399549:GH1O-1997-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Orotidine-5'-phosphate decarboxylaseImported (EC:4.1.1.23Imported)
Gene namesi
Ordered Locus Names:Msed_1966Imported
OrganismiMetallosphaera sedula (strain ATCC 51363 / DSM 5348)Imported
Taxonomic identifieri399549 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeMetallosphaera
ProteomesiUP000000242: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi399549.Msed_1966.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3VE7X-ray1.54A/B1-215[»]
3VE9X-ray1.45A/B1-215[»]
ProteinModelPortaliA4YI54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni139 – 1402Sulfate 1 bindingImported
Regioni191 – 1922Sulfate 2 bindingImported

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000226069.
KOiK01591.
OMAiTEMSHPG.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.

Sequencei

Sequence statusi: Complete.

A4YI54-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNRVILSLDS PIPEETLRKL NGKVAGIKVG WPLLLNLGKE KVKELVGLVD
60 70 80 90 100
GIKILDLKLA DIDNTMILIV DELKDITNSF IAHAFVGVEG SLASLSQRVD
110 120 130 140 150
LFLVLSMSHP GWNDAFYPYL REVARRVNPK GFVAPATRPS MISRVKGDFP
160 170 180 190 200
DKLVISPGVG TQGAKPGIAL CHGADYEIVG RSVYQSADPV RKLEEIVRSQ
210
EEVLSSCEGA KDRGS
Length:215
Mass (Da):23,404
Last modified:May 29, 2007 - v1
Checksum:iF7D9C7A64F668DCD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000682 Genomic DNA. Translation: ABP96106.1.
RefSeqiWP_012021893.1. NC_009440.1.
YP_001192030.1. NC_009440.1.

Genome annotation databases

EnsemblBacteriaiABP96106; ABP96106; Msed_1966.
GeneIDi5103353.
KEGGimse:Msed_1966.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000682 Genomic DNA. Translation: ABP96106.1 .
RefSeqi WP_012021893.1. NC_009440.1.
YP_001192030.1. NC_009440.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3VE7 X-ray 1.54 A/B 1-215 [» ]
3VE9 X-ray 1.45 A/B 1-215 [» ]
ProteinModelPortali A4YI54.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399549.Msed_1966.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP96106 ; ABP96106 ; Msed_1966 .
GeneIDi 5103353.
KEGGi mse:Msed_1966.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000226069.
KOi K01591.
OMAi TEMSHPG.

Enzyme and pathway databases

BioCyci MSED399549:GH1O-1997-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of the metal-mobilizing, extremely thermoacidophilic archaeon Metallosphaera sedula provides insights into bioleaching-associated metabolism."
    Auernik K.S., Maezato Y., Blum P.H., Kelly R.M.
    Appl. Environ. Microbiol. 74:682-692(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51363 / DSM 5348Imported.
  2. "Crystal structure of orotidine 5'-monophosphate decarboxylase from Metallosphaera sedula complexed with inhibitor BMP."
    Fedorov E.V., Desai B., Gerlt J.A., Almo S.C., Fedorov A.A.
    Submitted (JAN-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.54 ANGSTROMS).
  3. "Crystal structure of orotidine 5'-monophosphate decarboxylase from Metallosphaera sedula."
    Fedorov A.A., Fedorov E.V., Desai B., Gerlt J.A., Almo S.C.
    Submitted (JAN-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS).

Entry informationi

Entry nameiA4YI54_METS5
AccessioniPrimary (citable) accession number: A4YI54
Entry historyi
Integrated into UniProtKB/TrEMBL: May 29, 2007
Last sequence update: May 29, 2007
Last modified: October 29, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3