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A4YI53 (A4YI53_METS5) Unreviewed, UniProtKB/TrEMBL

Last modified November 16, 2011. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Orotate phosphoribosyltransferase HAMAP MF_01208
Short name=OPRT HAMAP MF_01208
Short name=OPRTase HAMAP MF_01208
EC=2.4.2.10 HAMAP MF_01208
Gene names
Name:pyrE HAMAP MF_01208
Ordered Locus Names:Msed_1965
OrganismMetallosphaera sedula (strain ATCC 51363 / DSM 5348) [Complete proteome] [HAMAP]
Taxonomic identifier399549 [NCBI]
Taxonomic lineageArchaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Metallosphaera

Protein attributes

Sequence length191 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208

Cofactor

Magnesium By similarity. HAMAP MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208

Subunit structure

Homodimer By similarity. HAMAP MF_01208

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily. HAMAP MF_01208

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region111 – 11995-phosphoribose 1-diphosphate binding By similarity HAMAP MF_01208

Sites

Binding site8615-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site9015-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site1151Orotate By similarity HAMAP MF_01208
Binding site1431Orotate By similarity HAMAP MF_01208

Sequences

Sequence LengthMass (Da)Tools
A4YI53 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: FB8BA9CAD202A9F3

FASTA19120,912
        10         20         30         40         50         60 
MDIGEVLVKR KLLLIGNFVL TSGKTSPYYI DLRRFPSYPE FRQVVDEAIK KVEKVDFDFI 

        70         80         90        100        110        120 
MGVATGGVPL ASFLACRMGI PMGYVRVERK GYGTDKLVEG EVTGRKVLVV DDVATTGGSL 

       130        140        150        160        170        180 
ERASAEIVRS GGKVVGALVI VDREEGASEK LRSLGIDFIS VFKISDILRS LSSTLSENER 

       190 
KLIEEYLGGT K

« Hide

References

[1]"The genome sequence of the metal-mobilizing, extremely thermoacidophilic archaeon Metallosphaera sedula provides insights into bioleaching-associated metabolism."
Auernik K.S., Maezato Y., Blum P.H., Kelly R.M.
Appl. Environ. Microbiol. 74:682-692(2008) [PubMed: 18083856] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000682 Genomic DNA. Translation: ABP96105.1.
RefSeqYP_001192029.1. NC_009440.1.

3D structure databases

ProteinModelPortalA4YI53.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4YI53.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5103352.
GenomeReviewsGene locus Msed_1965 in contig CP000682_GR.
KEGGmse:Msed_1965.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGarNOG09150.
HOGENOMHBG404341.
OMAQTCLVIN.
PhylomeDBA4YI53.
ProtClustDBPRK00455.

Family and domain databases

HAMAPMF_01208. PyrE.
[Tree]
InterProIPR004467. Or_phspho_trans_clade-1.
IPR023031. Orotate_PribosylTferase.
IPR000836. PRibTrfase.
[Graphical view]
KOK00762.
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR00336. PyrE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA4YI53_METS5
AccessionPrimary (citable) accession number: A4YI53
Entry history
Integrated into UniProtKB/TrEMBL: May 29, 2007
Last sequence update: May 29, 2007
Last modified: November 16, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info