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A4YI28

- SYL2_METS5

UniProt

A4YI28 - SYL2_METS5

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Protein

Leucine--tRNA ligase 2

Gene

leuS2

Organism
Metallosphaera sedula (strain ATCC 51363 / DSM 5348)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei634 – 6341ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMSED399549:GH1O-1971-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase 2UniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetase 2UniRule annotation
Short name:
LeuRS 2UniRule annotation
Gene namesi
Name:leuS2UniRule annotation
Ordered Locus Names:Msed_1940
OrganismiMetallosphaera sedula (strain ATCC 51363 / DSM 5348)
Taxonomic identifieri399549 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeMetallosphaera
ProteomesiUP000000242: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 950950Leucine--tRNA ligase 2PRO_0000334842Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399549.Msed_1940.

Structurei

3D structure databases

ProteinModelPortaliA4YI28.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi47 – 5711"HIGH" regionAdd
BLAST
Motifi631 – 6355"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
KOiK01869.
OMAiIDKWLLH.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

A4YI28-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MITIPSHEFT DLLNEISKKW QEEWSKNRIF EADPKDQKKF FTTVAFPYPN
60 70 80 90 100
SPFHLGHGRT YVTGDVYARF MRMKGYNVLF PMGFHFTGTP IITMADDVAK
110 120 130 140 150
GDKDLLDIFQ NIYEIPADVI PKLSDPLFMA NYFKEDIKAA MREIGLSIDW
160 170 180 190 200
RREFTTIDPQ FSAFIVWQFS KLQKKGYVVK DTHPVGWCPV HNLPVGMHDT
210 220 230 240 250
KGDMEPEIGE YVVIFFESKM GALAAATLRP ETIFGAVAVW VNPKATYTVA
260 270 280 290 300
EIWGKKVIVS EKAAEKLKFQ TDVKVLEKVS GSDLLKIVAI NPITGKEIPI
310 320 330 340 350
LPADFVDPTT ATGVVMSVPA HAPFDYFYLK KAKVGIEPIP VVAVEGQGDA
360 370 380 390 400
PAKDLVESSH PKNDADLKKL TEQLYRLEFN KGLMRSDILR LVKDELRAEL
410 420 430 440 450
SVVAGKQVPE ARKMVTDILI QRKAGTKMLE IMNKPVYCRC GNEVVVKILQ
460 470 480 490 500
DQWFLDYGNP EWKAKAKKLL DSMRVIPEET RKDFEYALDW LQKRACARTR
510 520 530 540 550
GLGTPLPWDK KWIIESLSDS TIYMAYYTLS HKIKEFGLHP SQLTEETWDY
560 570 580 590 600
IMLGEGDVKA ISERNKIGVD ALQELRRHFT YWYPLDLRHS GPDLIPNHLS
610 620 630 640 650
FFIFNHAGIF PENLWPRGVA VNGFILYEGK KMSKSLRNIV PLRKAIRTYG
660 670 680 690 700
ADVIRIALSS LVDMSSDANF TEAGARAIAD NLKRFYELMQ MQDGSTIDGT
710 720 730 740 750
PEKWLRSKLH RLVRDVTPLM ESMRFREVIN ELLFNLSSYI NEYLEMVRSE
760 770 780 790 800
SREYNRDVIR EVVETWTKLM APFAPHLTEE MWHQLGHNTF LSLESWPTPD
810 820 830 840 850
NSKINDQIEL EHEYHKLLIE DIRAILNVYK GKPSSVLLYV HDGSLNQVVK
860 870 880 890 900
SALDVLNSGG TMKDFMQKNT PKSKEEARVL QRIMQYVTEM PETVKKLIYS
910 920 930 940 950
NVNEMEVTRK GVPLLRYKLN LEIEVLAYTQ EVKQKLNKDA LPYRPAILVK
Length:950
Mass (Da):109,016
Last modified:May 29, 2007 - v1
Checksum:i3C6D2635D180537E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000682 Genomic DNA. Translation: ABP96080.1.
RefSeqiYP_001192004.2. NC_009440.1.

Genome annotation databases

EnsemblBacteriaiABP96080; ABP96080; Msed_1940.
GeneIDi5103327.
KEGGimse:Msed_1940.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000682 Genomic DNA. Translation: ABP96080.1 .
RefSeqi YP_001192004.2. NC_009440.1.

3D structure databases

ProteinModelPortali A4YI28.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399549.Msed_1940.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP96080 ; ABP96080 ; Msed_1940 .
GeneIDi 5103327.
KEGGi mse:Msed_1940.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000216620.
KOi K01869.
OMAi IDKWLLH.

Enzyme and pathway databases

BioCyci MSED399549:GH1O-1971-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_A. Leu_tRNA_synth_A.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the metal-mobilizing, extremely thermoacidophilic archaeon Metallosphaera sedula provides insights into bioleaching-associated metabolism."
    Auernik K.S., Maezato Y., Blum P.H., Kelly R.M.
    Appl. Environ. Microbiol. 74:682-692(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51363 / DSM 5348.

Entry informationi

Entry nameiSYL2_METS5
AccessioniPrimary (citable) accession number: A4YI28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 29, 2007
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3