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A4YI28

- SYL2_METS5

UniProt

A4YI28 - SYL2_METS5

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Protein
Leucine--tRNA ligase 2
Gene
leuS2, Msed_1940
Organism
Metallosphaera sedula (strain ATCC 51363 / DSM 5348)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei634 – 6341ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMSED399549:GH1O-1971-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase 2 (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase 2
Short name:
LeuRS 2
Gene namesi
Name:leuS2
Ordered Locus Names:Msed_1940
OrganismiMetallosphaera sedula (strain ATCC 51363 / DSM 5348)
Taxonomic identifieri399549 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeMetallosphaera
ProteomesiUP000000242: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 950950Leucine--tRNA ligase 2UniRule annotation
PRO_0000334842Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399549.Msed_1940.

Structurei

3D structure databases

ProteinModelPortaliA4YI28.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi47 – 5711"HIGH" regionUniRule annotation
Add
BLAST
Motifi631 – 6355"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
KOiK01869.
OMAiIDKWLLH.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

A4YI28-1 [UniParc]FASTAAdd to Basket

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MITIPSHEFT DLLNEISKKW QEEWSKNRIF EADPKDQKKF FTTVAFPYPN    50
SPFHLGHGRT YVTGDVYARF MRMKGYNVLF PMGFHFTGTP IITMADDVAK 100
GDKDLLDIFQ NIYEIPADVI PKLSDPLFMA NYFKEDIKAA MREIGLSIDW 150
RREFTTIDPQ FSAFIVWQFS KLQKKGYVVK DTHPVGWCPV HNLPVGMHDT 200
KGDMEPEIGE YVVIFFESKM GALAAATLRP ETIFGAVAVW VNPKATYTVA 250
EIWGKKVIVS EKAAEKLKFQ TDVKVLEKVS GSDLLKIVAI NPITGKEIPI 300
LPADFVDPTT ATGVVMSVPA HAPFDYFYLK KAKVGIEPIP VVAVEGQGDA 350
PAKDLVESSH PKNDADLKKL TEQLYRLEFN KGLMRSDILR LVKDELRAEL 400
SVVAGKQVPE ARKMVTDILI QRKAGTKMLE IMNKPVYCRC GNEVVVKILQ 450
DQWFLDYGNP EWKAKAKKLL DSMRVIPEET RKDFEYALDW LQKRACARTR 500
GLGTPLPWDK KWIIESLSDS TIYMAYYTLS HKIKEFGLHP SQLTEETWDY 550
IMLGEGDVKA ISERNKIGVD ALQELRRHFT YWYPLDLRHS GPDLIPNHLS 600
FFIFNHAGIF PENLWPRGVA VNGFILYEGK KMSKSLRNIV PLRKAIRTYG 650
ADVIRIALSS LVDMSSDANF TEAGARAIAD NLKRFYELMQ MQDGSTIDGT 700
PEKWLRSKLH RLVRDVTPLM ESMRFREVIN ELLFNLSSYI NEYLEMVRSE 750
SREYNRDVIR EVVETWTKLM APFAPHLTEE MWHQLGHNTF LSLESWPTPD 800
NSKINDQIEL EHEYHKLLIE DIRAILNVYK GKPSSVLLYV HDGSLNQVVK 850
SALDVLNSGG TMKDFMQKNT PKSKEEARVL QRIMQYVTEM PETVKKLIYS 900
NVNEMEVTRK GVPLLRYKLN LEIEVLAYTQ EVKQKLNKDA LPYRPAILVK 950
Length:950
Mass (Da):109,016
Last modified:May 29, 2007 - v1
Checksum:i3C6D2635D180537E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000682 Genomic DNA. Translation: ABP96080.1.
RefSeqiYP_001192004.2. NC_009440.1.

Genome annotation databases

EnsemblBacteriaiABP96080; ABP96080; Msed_1940.
GeneIDi5103327.
KEGGimse:Msed_1940.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000682 Genomic DNA. Translation: ABP96080.1 .
RefSeqi YP_001192004.2. NC_009440.1.

3D structure databases

ProteinModelPortali A4YI28.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399549.Msed_1940.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP96080 ; ABP96080 ; Msed_1940 .
GeneIDi 5103327.
KEGGi mse:Msed_1940.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000216620.
KOi K01869.
OMAi IDKWLLH.

Enzyme and pathway databases

BioCyci MSED399549:GH1O-1971-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_A. Leu_tRNA_synth_A.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the metal-mobilizing, extremely thermoacidophilic archaeon Metallosphaera sedula provides insights into bioleaching-associated metabolism."
    Auernik K.S., Maezato Y., Blum P.H., Kelly R.M.
    Appl. Environ. Microbiol. 74:682-692(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51363 / DSM 5348.

Entry informationi

Entry nameiSYL2_METS5
AccessioniPrimary (citable) accession number: A4YI28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 29, 2007
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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