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Protein

Leucine--tRNA ligase 2

Gene

leuS2

Organism
Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei634ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase 2UniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetase 2UniRule annotation
Short name:
LeuRS 2UniRule annotation
Gene namesi
Name:leuS2UniRule annotation
Ordered Locus Names:Msed_1940
OrganismiMetallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
Taxonomic identifieri399549 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeMetallosphaera
Proteomesi
  • UP000000242 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003348421 – 950Leucine--tRNA ligase 2Add BLAST950

Interactioni

Protein-protein interaction databases

STRINGi399549.Msed_1940

Structurei

3D structure databases

ProteinModelPortaliA4YI28
SMRiA4YI28
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi47 – 57"HIGH" regionAdd BLAST11
Motifi631 – 635"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00809 Archaea
COG0495 LUCA
HOGENOMiHOG000216620
KOiK01869
OMAiHVTGTPI
OrthoDBiPOG093Z006D

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_A Leu_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR002300 aa-tRNA-synth_Ia
IPR020791 Leu-tRNA-lgase_arc
IPR004493 Leu-tRNA-synth_Ia_arc/euk
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR11946:SF51 PTHR11946:SF51, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 2 hits
TIGRFAMsiTIGR00395 leuS_arch, 1 hit

Sequencei

Sequence statusi: Complete.

A4YI28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITIPSHEFT DLLNEISKKW QEEWSKNRIF EADPKDQKKF FTTVAFPYPN
60 70 80 90 100
SPFHLGHGRT YVTGDVYARF MRMKGYNVLF PMGFHFTGTP IITMADDVAK
110 120 130 140 150
GDKDLLDIFQ NIYEIPADVI PKLSDPLFMA NYFKEDIKAA MREIGLSIDW
160 170 180 190 200
RREFTTIDPQ FSAFIVWQFS KLQKKGYVVK DTHPVGWCPV HNLPVGMHDT
210 220 230 240 250
KGDMEPEIGE YVVIFFESKM GALAAATLRP ETIFGAVAVW VNPKATYTVA
260 270 280 290 300
EIWGKKVIVS EKAAEKLKFQ TDVKVLEKVS GSDLLKIVAI NPITGKEIPI
310 320 330 340 350
LPADFVDPTT ATGVVMSVPA HAPFDYFYLK KAKVGIEPIP VVAVEGQGDA
360 370 380 390 400
PAKDLVESSH PKNDADLKKL TEQLYRLEFN KGLMRSDILR LVKDELRAEL
410 420 430 440 450
SVVAGKQVPE ARKMVTDILI QRKAGTKMLE IMNKPVYCRC GNEVVVKILQ
460 470 480 490 500
DQWFLDYGNP EWKAKAKKLL DSMRVIPEET RKDFEYALDW LQKRACARTR
510 520 530 540 550
GLGTPLPWDK KWIIESLSDS TIYMAYYTLS HKIKEFGLHP SQLTEETWDY
560 570 580 590 600
IMLGEGDVKA ISERNKIGVD ALQELRRHFT YWYPLDLRHS GPDLIPNHLS
610 620 630 640 650
FFIFNHAGIF PENLWPRGVA VNGFILYEGK KMSKSLRNIV PLRKAIRTYG
660 670 680 690 700
ADVIRIALSS LVDMSSDANF TEAGARAIAD NLKRFYELMQ MQDGSTIDGT
710 720 730 740 750
PEKWLRSKLH RLVRDVTPLM ESMRFREVIN ELLFNLSSYI NEYLEMVRSE
760 770 780 790 800
SREYNRDVIR EVVETWTKLM APFAPHLTEE MWHQLGHNTF LSLESWPTPD
810 820 830 840 850
NSKINDQIEL EHEYHKLLIE DIRAILNVYK GKPSSVLLYV HDGSLNQVVK
860 870 880 890 900
SALDVLNSGG TMKDFMQKNT PKSKEEARVL QRIMQYVTEM PETVKKLIYS
910 920 930 940 950
NVNEMEVTRK GVPLLRYKLN LEIEVLAYTQ EVKQKLNKDA LPYRPAILVK
Length:950
Mass (Da):109,016
Last modified:May 29, 2007 - v1
Checksum:i3C6D2635D180537E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000682 Genomic DNA Translation: ABP96080.1

Genome annotation databases

EnsemblBacteriaiABP96080; ABP96080; Msed_1940
KEGGimse:Msed_1940

Similar proteinsi

Entry informationi

Entry nameiSYL2_METS5
AccessioniPrimary (citable) accession number: A4YI28
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 29, 2007
Last modified: March 28, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health