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Protein

Digeranylgeranylglyceryl phosphate synthase

Gene

Msed_1933

Organism
Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.UniRule annotation

Catalytic activityi

Geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate = diphosphate + 2,3-bis-O-(geranylgeranyl)glycerol 1-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: glycerophospholipid metabolism

This protein is involved in the pathway glycerophospholipid metabolism, which is part of Membrane lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycerophospholipid metabolism and in Membrane lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciMSED399549:GH1O-1964-MONOMER.
UniPathwayiUPA00940.

Names & Taxonomyi

Protein namesi
Recommended name:
Digeranylgeranylglyceryl phosphate synthaseUniRule annotation (EC:2.5.1.42UniRule annotation)
Short name:
DGGGP synthaseUniRule annotation
Short name:
DGGGPSUniRule annotation
Alternative name(s):
(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthaseUniRule annotation
Geranylgeranylglycerol-phosphate geranylgeranyltransferaseUniRule annotation
Gene namesi
Ordered Locus Names:Msed_1933
OrganismiMetallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
Taxonomic identifieri399549 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeMetallosphaera
Proteomesi
  • UP000000242 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3021HelicalUniRule annotationAdd
BLAST
Transmembranei37 – 5721HelicalUniRule annotationAdd
BLAST
Transmembranei76 – 9823HelicalUniRule annotationAdd
BLAST
Transmembranei102 – 11918HelicalUniRule annotationAdd
BLAST
Transmembranei126 – 14621HelicalUniRule annotationAdd
BLAST
Transmembranei217 – 23721HelicalUniRule annotationAdd
BLAST
Transmembranei260 – 28021HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284Digeranylgeranylglyceryl phosphate synthasePRO_0000350699Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399549.Msed_1933.

Family & Domainsi

Sequence similaritiesi

Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiarCOG00476. Archaea.
COG0382. LUCA.
HOGENOMiHOG000152645.
KOiK17105.
OMAiRIWIPVL.

Family and domain databases

HAMAPiMF_01286. DGGGP_synth. 1 hit.
InterProiIPR023547. DGGGP_synth.
IPR000537. UbiA_prenyltransferase.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4YI21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPFLKLVRI HNVIGAGLGA FTGYVASSMW KIDPTELILA VLVVALVDAG
60 70 80 90 100
GNAINDVYDV EIDRINKPDR PIPSGAVSLR TATSLSYGLM GVGVILSALQ
110 120 130 140 150
GYLQFLVALL TSVALIFYAR DLKRTGIYGN LVVATATALS LFYGGLSYHE
160 170 180 190 200
GDWLQRIWIP VLYTFLLTLS REIVKGIEDY RGDLANHVNT LATTRGIASA
210 220 230 240 250
WRVARVALII TEVTSPLPLF LGYNILYGIV LVPFLYITTK AVLAETSEEG
260 270 280
ASKARSLLKG SAFLGMVAFA LGSLPFQFLF HYLP
Length:284
Mass (Da):30,818
Last modified:May 29, 2007 - v1
Checksum:i0C1FC66AAC23CE45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000682 Genomic DNA. Translation: ABP96073.1.

Genome annotation databases

EnsemblBacteriaiABP96073; ABP96073; Msed_1933.
KEGGimse:Msed_1933.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000682 Genomic DNA. Translation: ABP96073.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi399549.Msed_1933.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP96073; ABP96073; Msed_1933.
KEGGimse:Msed_1933.

Phylogenomic databases

eggNOGiarCOG00476. Archaea.
COG0382. LUCA.
HOGENOMiHOG000152645.
KOiK17105.
OMAiRIWIPVL.

Enzyme and pathway databases

UniPathwayiUPA00940.
BioCyciMSED399549:GH1O-1964-MONOMER.

Family and domain databases

HAMAPiMF_01286. DGGGP_synth. 1 hit.
InterProiIPR023547. DGGGP_synth.
IPR000537. UbiA_prenyltransferase.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDGGGP_METS5
AccessioniPrimary (citable) accession number: A4YI21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 23, 2008
Last sequence update: May 29, 2007
Last modified: September 7, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.