A4YHW1 (AROC_METS5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chorismate synthase
EC=4.2.3.5

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	Msed_1873

Organism

Metallosphaera sedula (strain ATCC 51363 / DSM 5348) [Complete proteome] [HAMAP]

Taxonomic identifier

399549 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Metallosphaera

Protein attributes

Sequence length	390 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity. HAMAP MF_00300
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 390	390	Chorismate synthase HAMAP MF_00300		PRO_1000071971

Sequences

	Sequence		Length	Mass (Da)
	A4YHW1 [UniParc]. Last modified May 29, 2007. Version 1. Checksum: DEC33C304674BC7F	FASTA	390	42,387
	10 20 30 40 50 60 MPGNSFGKIF RITTFGESHG PAVGVVVDGV PAGLRLSQED LEFELSFRRP GRLYVSGRRE 70 80 90 100 110 120 KDVPEILSGV YNGRTTGSPI AIVVKNTDVI SSFYEEVKVK PRPGHADLPF IMRYGYENWD 130 140 150 160 170 180 YRGGGRSSAR ETVGRVAAGA IAKKLLMFHD TWIAGRLKSL GPVDSPPADF LQILCSKYSP 190 200 210 220 230 240 VRASDPETEA KFQELVKQAT VEGDSYGGVA EIVVKNPPAG LGEPVFDKIK ADLAKAILSI 250 260 270 280 290 300 PAVTGFEYGL GFQASRMKGS EANDSIVRKG ERLGWRENKS GGILGGITTG EDIVVRCSFK 310 320 330 340 350 360 PTSSIRKPQG TVDLRTGEPA EISVLGRHDP AVAIRGVSVA ESMVALTLVD HSLRSGVIPP 370 380 390 VKLEERQAEV IEDRWRRYME ECRPTAESQS

References

[1]

"The genome sequence of the metal-mobilizing, extremely thermoacidophilic archaeon Metallosphaera sedula provides insights into bioleaching-associated metabolism." Auernik K.S., Maezato Y., Blum P.H., Kelly R.M. Appl. Environ. Microbiol. 74:682-692(2008) [PubMed: 18083856] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51363 / DSM 5348.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000682 Genomic DNA. Translation: ABP96013.1.
RefSeq	YP_001191937.1. NC_009440.1.
3D structure databases
ProteinModelPortal	A4YHW1.
ModBase	Search...
Protein-protein interaction databases
STRING	A4YHW1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5104141.
GenomeReviews	Gene locus Msed_1873 in contig CP000682_GR.
KEGG	mse:Msed_1873.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG04618.
HOGENOM	HBG292336.
OMA	SRFTTQR.
PhylomeDB	A4YHW1.
ProtClustDB	PRK05382.
Enzyme and pathway databases
BioCyc	MSED399549:MSED_1873-MONOMER.
Family and domain databases
HAMAP	MF_00300. Chorismate_synth. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
KO	K01736.
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
SUPFAM	SSF103263. Chorismate_synth. 1 hit.
TIGRFAMs	TIGR00033. AroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_METS5

Accession

Primary (citable) accession number: A4YHW1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	May 29, 2007
Last modified:	November 16, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program