A4YHV8 (AROD_METS5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-dehydroquinate dehydratase
Short name=3-dehydroquinase
EC=4.2.1.10

Alternative name(s):
Type I DHQase

Gene names

Name:	aroD
Ordered Locus Names:	Msed_1870

Organism

Metallosphaera sedula (strain ATCC 51363 / DSM 5348) [Complete proteome] [HAMAP]

Taxonomic identifier

399549 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Metallosphaera

Protein attributes

Sequence length	204 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP MF_00214
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP MF_00214
Sequence similarities	Belongs to the type-I 3-dehydroquinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 204	204	3-dehydroquinate dehydratase HAMAP MF_00214		PRO_0000325534
Sites
	Active site	108	1	Proton acceptor By similarity
	Active site	133	1	Schiff-base intermediate with substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A4YHV8 [UniParc]. Last modified May 29, 2007. Version 1. Checksum: FC66778515387CDF	FASTA	204	23,530
	10 20 30 40 50 60 MNRPLIVASL PVTSPGDISR VKDIDADLVE LRLDYSREFP RPQDLLPYRD RILVTLRDRE 70 80 90 100 110 120 EGGQGNFTDN FKETFLNELM KLGILYDVEA SFLSRRRVQF REKVVSAHYF HRLPSREEVD 130 140 150 160 170 180 CLFSTYREAF TVKIAVSNLP GYREILSYIS TKPGSTFMPM SPDPLERLAI SLLGSRLLYT 190 200 YVDSPTATGQ LHYLEAKRIL NCLF

References

[1]

"The genome sequence of the metal-mobilizing, extremely thermoacidophilic archaeon Metallosphaera sedula provides insights into bioleaching-associated metabolism." Auernik K.S., Maezato Y., Blum P.H., Kelly R.M. Appl. Environ. Microbiol. 74:682-692(2008) [PubMed: 18083856] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51363 / DSM 5348.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000682 Genomic DNA. Translation: ABP96010.1.
RefSeq	YP_001191934.1. NC_009440.1.
3D structure databases
ProteinModelPortal	A4YHV8.
ModBase	Search...
Protein-protein interaction databases
STRING	A4YHV8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5104138.
GenomeReviews	Gene locus Msed_1870 in contig CP000682_GR.
KEGG	mse:Msed_1870.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG10792.
HOGENOM	HBG553407.
OMA	ILYDVEA.
ProtClustDB	PRK13576.
Enzyme and pathway databases
BioCyc	MSED399549:MSED_1870-MONOMER.
Family and domain databases
HAMAP	MF_00214. AroD. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR001381. DHquinase_I. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K03785.
Pfam	PF01487. DHquinase_I. 1 hit. [Graphical view]
PROSITE	PS01028. DEHYDROQUINASE_I. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROD_METS5

Accession

Primary (citable) accession number: A4YHV8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	May 29, 2007
Last modified:	November 16, 2011
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program