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Protein

Ribonuclease Z

Gene

rnz

Organism
Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi60Zinc 1; catalyticUniRule annotation1
Metal bindingi62Zinc 1; catalyticUniRule annotation1
Active sitei64Proton acceptorUniRule annotation1
Metal bindingi64Zinc 2; catalyticUniRule annotation1
Metal bindingi65Zinc 2; catalyticUniRule annotation1
Metal bindingi132Zinc 1; catalyticUniRule annotation1
Metal bindingi200Zinc 1; catalyticUniRule annotation1
Metal bindingi200Zinc 2; catalyticUniRule annotation1
Metal bindingi256Zinc 2; catalyticUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processtRNA processing
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease ZUniRule annotation (EC:3.1.26.11UniRule annotation)
Short name:
RNase ZUniRule annotation
Alternative name(s):
tRNA 3 endonucleaseUniRule annotation
tRNase ZUniRule annotation
Gene namesi
Name:rnzUniRule annotation
Ordered Locus Names:Msed_1788
OrganismiMetallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
Taxonomic identifieri399549 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeMetallosphaera
Proteomesi
  • UP000000242 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000736841 – 291Ribonuclease ZAdd BLAST291

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi399549.Msed_1788.

Structurei

3D structure databases

ProteinModelPortaliA4YHP1.
SMRiA4YHP1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase Z family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00501. Archaea.
COG1234. LUCA.
HOGENOMiHOG000272419.
KOiK00784.
OMAiGTQRQMM.
OrthoDBiPOG093Z04VY.

Family and domain databases

CDDicd07717. RNaseZ_ZiPD-like_MBL-fold. 1 hit.
Gene3Di3.60.15.10. 1 hit.
HAMAPiMF_01818. RNase_Z_BN. 1 hit.
InterProiView protein in InterPro
IPR001279. Metallo-B-lactamas.
IPR013471. RNase_Z/BN.
PfamiView protein in Pfam
PF00753. Lactamase_B. 1 hit.
PF12706. Lactamase_B_2. 1 hit.
SUPFAMiSSF56281. SSF56281. 1 hit.
TIGRFAMsiTIGR02651. RNase_Z. 1 hit.

Sequencei

Sequence statusi: Complete.

A4YHP1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKVYFIGTG GGAPSRRGLP AYLVRREGLS ILMDCGEGTQ ITMIRNSLNI
60 70 80 90 100
MNVNVIAITH LHADHVLGLP SLIQTMGMYD RKERLYILGP EGLKDLLTET
110 120 130 140 150
FERTYFSPNF PIEFVSSYES QGIRVRPFRT CHVVPSQGYL VEEKDTANLD
160 170 180 190 200
AERLRREGVT DWRVMRMLKE GKEVPWGDRV LKPEDYLIVK RGIRIAYTGD
210 220 230 240 250
TRPCETVINS VKGVDLLLHD STFEQGIDAS EYGHSTSTEA ATVAREAEVK
260 270 280 290
RLALIHISAR YRDTSEMLKQ ARRIFPMSFV PEDLSFLNLR A
Length:291
Mass (Da):33,031
Last modified:May 29, 2007 - v1
Checksum:i189B06379D5DF798
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000682 Genomic DNA. Translation: ABP95943.1.
RefSeqiWP_012021730.1. NC_009440.1.

Genome annotation databases

EnsemblBacteriaiABP95943; ABP95943; Msed_1788.
GeneIDi5104788.
KEGGimse:Msed_1788.

Similar proteinsi

Entry informationi

Entry nameiRNZ_METS5
AccessioniPrimary (citable) accession number: A4YHP1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 29, 2007
Last modified: August 30, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families