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Protein

Probable deoxyhypusine synthase

Gene

dys

Organism
Metallosphaera sedula (strain ATCC 51363 / DSM 5348)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.UniRule annotation

Catalytic activityi

[eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine.UniRule annotation

Cofactori

NAD+UniRule annotation

Pathwayi: eIF5A hypusination

This protein is involved in the pathway eIF5A hypusination, which is part of Protein modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway eIF5A hypusination and in Protein modification.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei283 – 2831NucleophileUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Hypusine biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciMSED399549:GH1O-1777-MONOMER.
UniPathwayiUPA00354.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable deoxyhypusine synthaseUniRule annotation (EC:2.5.1.46UniRule annotation)
Short name:
DHSUniRule annotation
Gene namesi
Name:dysUniRule annotation
Ordered Locus Names:Msed_1753
OrganismiMetallosphaera sedula (strain ATCC 51363 / DSM 5348)
Taxonomic identifieri399549 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeMetallosphaera
Proteomesi
  • UP000000242 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Probable deoxyhypusine synthasePRO_1000071529Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399549.Msed_1753.

Structurei

3D structure databases

ProteinModelPortaliA4YHK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the deoxyhypusine synthase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04142. Archaea.
COG1899. LUCA.
HOGENOMiHOG000228838.
KOiK00809.
OMAiSWGKIKE.

Family and domain databases

Gene3Di3.40.910.10. 1 hit.
HAMAPiMF_00153. DHS.
InterProiIPR022899. Deoxyhypus_synthase_arc.
IPR002773. Deoxyhypusine_synthase.
IPR029035. DHS-like_NAD/FAD-binding_dom.
[Graphical view]
PANTHERiPTHR11703. PTHR11703. 1 hit.
PfamiPF01916. DS. 1 hit.
[Graphical view]
SUPFAMiSSF52467. SSF52467. 1 hit.

Sequencei

Sequence statusi: Complete.

A4YHK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRREDILVEE VQDITLDDLR GSSLLEVYNK IYGFSAESIY RGSRILKRIV
60 70 80 90 100
SECDLRFISF TANLVSTGLR GLFADMIRRG YFNMVVTTGG TIDHDIARSF
110 120 130 140 150
GGKYYKGSFE FSDEELRKIN VHRLGNILIP FEDYGGMVEN AVNRILPPLV
160 170 180 190 200
KEKREWSVYE LLWEFGKRIE DKHSILRAAY ETNTPIIVPG VVDGSFGTNL
210 220 230 240 250
FIQSQFTGLR INLFEDMRLI KDRVFSSKMA GALLIGGGIS KHHTIWWNQF
260 270 280 290 300
RDGLDYAVYL TTAQEFDGSL SGARPREAIS WNKIRENAEQ AVIYADATLA
310
LPILATSLIS
Length:310
Mass (Da):35,171
Last modified:May 29, 2007 - v1
Checksum:iA4AD94318DD44C03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000682 Genomic DNA. Translation: ABP95908.1.
RefSeqiWP_012021695.1. NC_009440.1.

Genome annotation databases

EnsemblBacteriaiABP95908; ABP95908; Msed_1753.
GeneIDi5104753.
KEGGimse:Msed_1753.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000682 Genomic DNA. Translation: ABP95908.1.
RefSeqiWP_012021695.1. NC_009440.1.

3D structure databases

ProteinModelPortaliA4YHK6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi399549.Msed_1753.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP95908; ABP95908; Msed_1753.
GeneIDi5104753.
KEGGimse:Msed_1753.

Phylogenomic databases

eggNOGiarCOG04142. Archaea.
COG1899. LUCA.
HOGENOMiHOG000228838.
KOiK00809.
OMAiSWGKIKE.

Enzyme and pathway databases

UniPathwayiUPA00354.
BioCyciMSED399549:GH1O-1777-MONOMER.

Family and domain databases

Gene3Di3.40.910.10. 1 hit.
HAMAPiMF_00153. DHS.
InterProiIPR022899. Deoxyhypus_synthase_arc.
IPR002773. Deoxyhypusine_synthase.
IPR029035. DHS-like_NAD/FAD-binding_dom.
[Graphical view]
PANTHERiPTHR11703. PTHR11703. 1 hit.
PfamiPF01916. DS. 1 hit.
[Graphical view]
SUPFAMiSSF52467. SSF52467. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of the metal-mobilizing, extremely thermoacidophilic archaeon Metallosphaera sedula provides insights into bioleaching-associated metabolism."
    Auernik K.S., Maezato Y., Blum P.H., Kelly R.M.
    Appl. Environ. Microbiol. 74:682-692(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51363 / DSM 5348.

Entry informationi

Entry nameiDHYS_METS5
AccessioniPrimary (citable) accession number: A4YHK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 29, 2007
Last modified: December 9, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.