A4YHD8 (TRPC_METS5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	Msed_1685

Organism

Metallosphaera sedula (strain ATCC 51363 / DSM 5348) [Complete proteome] [HAMAP]

Taxonomic identifier

399549 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Metallosphaera

Protein attributes

Sequence length	250 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_A
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_A
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 250	250	Indole-3-glycerol phosphate synthase HAMAP MF_00134_A		PRO_1000071435

Sequences

	Sequence		Length	Mass (Da)
	A4YHD8 [UniParc]. Last modified May 29, 2007. Version 1. Checksum: 93BBFBBE1381D601	FASTA	250	27,997
	10 20 30 40 50 60 MPRYLEGWIK DVVENAKRRP YVSRSREKPV LQIIPRIRAV KGAGLNPVIA EYKRKSPSGF 70 80 90 100 110 120 SEDRDPISYA KSMEQGGAVA ISVITENTVF GGSYEYLERI ARNVKIPLLM KDFVVSENQV 130 140 150 160 170 180 DTAYDLGADF VLLIVRILTE RELSGLLEYV RSYGMEALVE VHDREDLDIA LRSGASLIGV 190 200 210 220 230 240 NSRDLFSLTI QKEMAMKLLE QIPSTVTKVA ESGIESAEEI RLLREKGADA FLIGSSLMRN 250 PDKIKEFVQG

References

[1]

"The genome sequence of the metal-mobilizing, extremely thermoacidophilic archaeon Metallosphaera sedula provides insights into bioleaching-associated metabolism." Auernik K.S., Maezato Y., Blum P.H., Kelly R.M. Appl. Environ. Microbiol. 74:682-692(2008) [PubMed: 18083856] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51363 / DSM 5348.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000682 Genomic DNA. Translation: ABP95840.1.
RefSeq	YP_001191764.1. NC_009440.1.
3D structure databases
ProteinModelPortal	A4YHD8.
SMR	A4YHD8. Positions 29-248.
ModBase	Search...
Protein-protein interaction databases
STRING	A4YHD8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5105331.
GenomeReviews	Gene locus Msed_1685 in contig CP000682_GR.
KEGG	mse:Msed_1685.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG04622.
HOGENOM	HBG540956.
OMA	MRKDDVT.
PhylomeDB	A4YHD8.
ProtClustDB	PRK00278.
Enzyme and pathway databases
BioCyc	MSED399549:MSED_1685-MONOMER.
Family and domain databases
HAMAP	MF_00134_A. IGPS_A. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_METS5

Accession

Primary (citable) accession number: A4YHD8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	May 29, 2007
Last modified:	November 16, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program